| URN | urn:agi-Regulation:inout-urn:agi-llid:5167:out-urn:agi-llid:3643::negative |
|---|---|
| References | 16 |
| Connectivity | 2 |
| Effect | negative |
| Original # of References | 13 |
| TextRef | info:pmid/16897338#abs:1 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Mamm Genome |
| MedLine Reference | 16897338:0 |
| Sentence | The ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is an inhibitor of the insulin receptor. |
| TextRef | info:pmid/10615944#abs:1 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Diabetes |
| MedLine Reference | 10615944:0 |
| Sentence | Plasma cell membrane glycoprotein-1 inhibits insulin receptor (IR) tyrosine kinase activity and subsequent cellular signaling. |
| TextMods | 36: '(PC-1) ' -> '' |
| TextRef | info:pmid/17065358#abs:1 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Diabetes |
| MedLine Reference | 17065358:0 |
| Sentence | Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is an inhibitor of insulin-induced activation of the insulin receptor. |
| TextRef | info:pmid/18719658#abs:1 |
|---|---|
| PubYear | 2008 |
| MedlineTA | Obesity (Silver Spring) |
| MedLine Reference | 18719658:0 |
| Sentence | The ectoenzyme ENPP1 (also termed membrane glycoprotein PC-1 or ENPP1/PC-1) is an inhibitor of insulin-induced activation of the insulin receptor. |
| TextRef | info:pmid/18948963#abs:1 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Obesity (Silver Spring) |
| MedLine Reference | 18948963:0 |
| Sentence | Ectonucleotide Pyrophosphatase Phosphodiesterase 1 (ENPP1) downregulates insulin signaling by inhibiting the insulin receptor's tyrosine-kinase. |
| TextRef | info:pmid/17491709#abs:1 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Rev Diabet Stud |
| MedLine Reference | 17491709:0 |
| Sentence | Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is known to influence insulin sensitivity by inhibiting insulin receptor signaling. |
| TextRef | info:pmid/19083193#abs:1 |
|---|---|
| PubYear | 2009 |
| MedlineTA | J Mol Med |
| MedLine Reference | 19083193:0 |
| Sentence | Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin-receptor signaling and, when over-expressed, induces insulin resistance in vitro and in vivo. |
| TextMods | 85: '(IR) ' -> '' |
| TextRef | info:pmid/17563456#abs:3 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Curr Opin Clin Nutr Metab Care |
| MedLine Reference | 17563456:2 |
| Sentence | The transmembrane glycoprotein ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin receptor signalling and has recently emerged as a key player in the development of insulin resistance. |
| TextRef | info:pmid/19656007#abs:2 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Metab Syndr Relat Disord |
| MedLine Reference | 19656007:1 |
| Sentence | Membrane glycoprotein PC-1 (also termed ENPP1) is a direct insulin receptor inhibitor, and certain polymorphisms of the ENPP1/PC-1 gene have been associated with insulin resistance, type 2 diabetes, obesity, and diabetic complications. |
| TextRef | info:pmid/17986276#abs:2 |
|---|---|
| PubYear | 2008 |
| MedlineTA | Clin Endocrinol (Oxf) |
| MedLine Reference | 17986276:1 |
| Sentence | Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), originally described as a plasma cell allo-antigen and named plasma cell membrane glycoprotein (PC-1), is an inhibitor of insulin-induced activation of the insulin receptor. |
| CellType | Plasma Cells |
| TextRef | info:pmid/15793263#body:162 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Diabetes |
| MedLine Reference | 15793263:1161 |
| Sentence | Maddux et al. (22) have reported that ENPP1 may inhibit the insulin receptor by interacting directly with a specific region in the α-subunit. |
| TextRef | info:pmid/15677494#body:57 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Diabetes |
| MedLine Reference | 15677494:1056 |
| Sentence | In addition, overexpression of plasma cell membrane glycoprotein-1 in cultured cells reduces both insulin-stimulated insulin receptor (insulin receptor) activation and downstream signaling (10). |
| CellType | Fibroblasts |
| TextMods | 31: 'PC-1 ' -> 'plasma cell membrane glycoprotein-1 ' 135: 'IR' -> 'insulin receptor' |
| TextRef | info:pmid/15294885#body:993 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Endocr Rev |
| MedLine Reference | 15294885:1992 |
| Sentence | Interestingly, ENPP1 suppresses insulin receptor tyrosine kinase activity, apparently through a direct interaction with the insulin receptor α-subunit, and thus leads to insulin resistance (666, 667, 668, 669). |
| TextRef | info:pmid/15793263#cont:123 |
|---|---|
| MedLine Reference | 15793263:10122 |
| Sentence | Maddux et al. ( 22 ) have reported that ENPP1 may inhibit the insulin receptor by interacting directly with a specific region in the α-subunit. |
| Journal | Diabetes |
| Journal Reference | v54 i4 p1207 |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/54/4/1207 |
| TextRef | info:pmid/15294885#cont:941 |
|---|---|
| MedLine Reference | 15294885:10940 |
| Sentence | Interestingly, ENPP1 suppresses insulin receptor tyrosine kinase activity, apparently through a direct interaction with the insulin receptor α-subunit, and thus leads to insulin resistance ( 666 , 667 , 668 , 669 ). |
| Journal | Endocrine Reviews |
| Journal Reference | v25 i4 p629 |
| Journal Link | http://edrv.endojournals.org/cgi/content/full/25/4/629 |
| TextRef | info:pmid/15677494#cont:112 |
|---|---|
| Organ | Liver |
| MedLine Reference | 15677494:10111 |
| Sentence | In view of the fact that PC-1 inhibits IR autophosphorylation ( 5 ), we studied insulin activation of this function and the downstream mediator of IR signaling, Akt/PKB, in liver from adenovirus PC-1 animals in the fed state (see below). |
| Journal | Diabetes |
| Journal Reference | v54 i2 p367 |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/54/2/367 |