Ariadne Genomics Inc. Irs1 Sh2b2 PY_multiple PY972 Socs1 Socs3 Socs6 Socs7 Insr --+> Shc1 Insr --+> Irs2 Shc1 Grb2 ---- Irs1 Grb2 Sos2 Sos1 Irs2 Socs7 ---| Insr Socs3 ---| Insr Socs6 ---| Insr Socs1 ---| Insr Grb2 ---- Sos1 insulin responsive facilitative sugar transporter mediated glucose transport pathway Ins2 ---- Insr Grb10 Grb14 Insr --+> Irs3 Irs3 Insr Insr --+> Irs4 Irs4 Pkcs Insr --+> Irs1 Ptpn1 Enpp1 Ptprf phosphatidylinositol 3-kinase-Akt signaling pathway Insr --+> insulin responsive facilitative sugar transporter mediated glucose transport pathway Insr --+> Sh2b2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ptpn11 Ins2 Ptpn1 ---| Insr Ptprf ---| Insr Grb2 ---- Shc1 Grb2 ---- Sos2 Irs2 ---- Ptpn11 Grb2 ---- Irs2 Pik3r1 Pkcs ---| Irs1 Pkcs ---| Insr Enpp1 ---| Insr Grb10 ---| Insr Grb14 ---| Insr Irs2 ---- Pik3r1 Irs1 ---- Pik3r1 Ins1 ---- Insr Ins1 Irs2 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Irs1 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Ptpn11 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway