| URN | urn:agi-llid:948 |
|---|---|
| Connectivity | 481 |
| Name | Cd36 |
| Description | CD36 molecule (thrombospondin receptor) |
| Notes | The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] |
| Pathway | retinol metabolic pathway |
|---|
| GO Molecular Function | lipid binding |
|---|---|
| lipoprotein binding | |
| lipoteichoic acid receptor activity | |
| fatty acid binding | |
| high-density lipoprotein binding | |
| low-density lipoprotein binding | |
| transforming growth factor beta binding | |
| low-density lipoprotein receptor activity | |
| Gram-positive bacterial cell surface binding | |
| Gram-negative bacterial cell surface binding | |
| receptor activity | |
| thrombospondin receptor activity |
| GO Cellular Component | apical part of cell |
|---|---|
| cell surface | |
| membrane | |
| intracellular | |
| plasma membrane | |
| membrane raft | |
| Golgi apparatus | |
| mitochondrion | |
| platelet alpha granule membrane | |
| membrane fraction | |
| microsome | |
| external side of plasma membrane | |
| caveola | |
| integral to membrane | |
| integral to plasma membrane | |
| sarcolemma |
| GO Biological Process | cell adhesion |
|---|---|
| lipoprotein particle clearance | |
| transport | |
| response to activity | |
| defense response to Gram-positive bacterium | |
| negative regulation of growth of symbiont in host | |
| negative regulation of angiogenesis | |
| positive regulation of macrophage derived foam cell differentiation | |
| low-density lipoprotein particle clearance | |
| blood coagulation | |
| positive regulation of interleukin-12 production | |
| positive regulation of interleukin-6 production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of macrophage cytokine production | |
| phagocytosis, recognition | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of MAPKKK cascade | |
| cGMP-mediated signaling | |
| positive regulation of cell-matrix adhesion | |
| positive regulation of phagocytosis, engulfment | |
| apoptotic cell clearance | |
| fatty acid metabolic process | |
| long-chain fatty acid metabolic process | |
| fatty acid oxidation | |
| lipoprotein catabolic process | |
| triglyceride metabolic process | |
| cellular response to insulin stimulus | |
| cellular response to lipopolysaccharide | |
| cellular response to lipoteichoic acid | |
| cellular response to bacterial lipopeptide | |
| pattern recognition receptor signaling pathway | |
| response to mechanical stimulus | |
| response to drug | |
| response to nutrient | |
| response to growth hormone stimulus | |
| response to estradiol stimulus | |
| positive regulation of cholesterol storage | |
| lipid metabolic process | |
| lipoprotein transport | |
| fatty acid transport | |
| cholesterol transport | |
| long-chain fatty acid transport | |
| plasma membrane long-chain fatty acid transport | |
| nitric oxide mediated signal transduction | |
| lipid storage |
| Ariadne Ontology | Receptors |
|---|
| Group | Receptors |
|---|---|
| cell adhesion | |
| lipoprotein particle clearance | |
| transport | |
| response to activity | |
| defense response to Gram-positive bacterium | |
| negative regulation of growth of symbiont in host | |
| negative regulation of angiogenesis | |
| positive regulation of macrophage derived foam cell differentiation | |
| low-density lipoprotein particle clearance | |
| blood coagulation | |
| positive regulation of interleukin-12 production | |
| positive regulation of interleukin-6 production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of macrophage cytokine production | |
| phagocytosis, recognition | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of MAPKKK cascade | |
| cGMP-mediated signaling | |
| positive regulation of cell-matrix adhesion | |
| positive regulation of phagocytosis, engulfment | |
| apoptotic cell clearance | |
| fatty acid metabolic process | |
| long-chain fatty acid metabolic process | |
| fatty acid oxidation | |
| lipoprotein catabolic process | |
| triglyceride metabolic process | |
| cellular response to insulin stimulus | |
| cellular response to lipopolysaccharide | |
| cellular response to lipoteichoic acid | |
| cellular response to bacterial lipopeptide | |
| pattern recognition receptor signaling pathway | |
| response to mechanical stimulus | |
| response to drug | |
| response to nutrient | |
| response to growth hormone stimulus | |
| response to estradiol stimulus | |
| positive regulation of cholesterol storage | |
| lipid metabolic process | |
| lipoprotein transport | |
| fatty acid transport | |
| cholesterol transport | |
| long-chain fatty acid transport | |
| plasma membrane long-chain fatty acid transport | |
| nitric oxide mediated signal transduction | |
| lipid storage | |
| lipid binding | |
| lipoprotein binding | |
| lipoteichoic acid receptor activity | |
| fatty acid binding | |
| high-density lipoprotein binding | |
| low-density lipoprotein binding | |
| transforming growth factor beta binding | |
| low-density lipoprotein receptor activity | |
| Gram-positive bacterial cell surface binding | |
| Gram-negative bacterial cell surface binding | |
| receptor activity | |
| thrombospondin receptor activity | |
| apical part of cell | |
| cell surface | |
| membrane | |
| intracellular | |
| plasma membrane | |
| membrane raft | |
| Golgi apparatus | |
| mitochondrion | |
| platelet alpha granule membrane | |
| membrane fraction | |
| microsome | |
| external side of plasma membrane | |
| caveola | |
| integral to membrane | |
| integral to plasma membrane | |
| sarcolemma |
| MedScan ID | 948 |
|---|
| Hugo ID | 1663 |
|---|
| Human chromosome position | 7q11.2 |
|---|
| LocusLink ID | 948 |
|---|---|
| 12491 | |
| 29184 | |
| 499985 | |
| 685953 |
| Alias | FAT |
|---|---|
| GP4 | |
| GP3B | |
| GPIV | |
| CHDS7 | |
| PASIV | |
| SCARB3 | |
| platelet glycoprotein 4 | |
| GPIIIB | |
| PAS IV | |
| PAS-4 protein | |
| glycoprotein IIIb | |
| OTTHUMP00000207872 | |
| cluster determinant 36 | |
| fatty acid translocase | |
| platelet glycoprotein IV | |
| scavenger receptor class B, member 3 | |
| leukocyte differentiation antigen CD36 | |
| CD36 antigen (collagen type I receptor, thrombospondin receptor) | |
| PAS-4 | |
| MGC91634 | |
| MGC108510 | |
| adipocyte membrane protein | |
| fatty acid transport protein | |
| collagen type I receptor thrombospondin receptor | |
| Cd36 antigen-like | |
| similar to CD36 antigen | |
| Cd36 | |
| CD36 antigen | |
| CD36 molecule | |
| CD36 molecule (thrombospondin receptor) | |
| collagen type 1 receptor | |
| collagen type I receptor | |
| FAT/CD36 | |
| glycoprotein III b | |
| LOC296786 | |
| LOC362310 | |
| LOC683013 | |
| LOC685953 | |
| PAS-IV | |
| RGD1565355 | |
| scavenger receptor class B, member III | |
| thrombospondin receptor | |
| thrombospondin receptors |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 173510 |
|---|---|
| 610938 | |
| 248310 | |
| 611162 | |
| 608404 |
| Mouse chromosome position | 5 2.0 cM |
|---|
| GO ID | 0008035 |
|---|---|
| 0008289 | |
| 0008034 | |
| 0030169 | |
| 0005041 | |
| 0070053 | |
| 0050431 | |
| 0043277 | |
| 0007596 | |
| 0019934 | |
| 0007155 | |
| 0030301 | |
| 0006629 | |
| 0019915 | |
| 0042159 | |
| 0034381 | |
| 0042953 | |
| 0034383 | |
| 0007263 | |
| 0015911 | |
| 0001954 | |
| 0010886 | |
| 0010744 | |
| 0006810 | |
| 0005794 | |
| 0009986 | |
| 0005887 | |
| 0005624 | |
| 0045121 | |
| 0005886 | |
| 0031092 | |
| 0051636 | |
| 0051637 | |
| 0070892 | |
| 0004872 | |
| 0071221 | |
| 0071222 | |
| 0071223 | |
| 0050830 | |
| 0006631 | |
| 0019395 | |
| 0015908 | |
| 0001676 | |
| 0015909 | |
| 0016525 | |
| 0044130 | |
| 0006910 | |
| 0043123 | |
| 0043410 | |
| 0032735 | |
| 0032755 | |
| 0060907 | |
| 0060100 | |
| 0032760 | |
| 0009612 | |
| 0006641 | |
| 0045177 | |
| 0005901 | |
| 0009897 | |
| 0016021 | |
| 0005622 | |
| 0016020 | |
| 0005792 | |
| 0005739 | |
| 0042383 | |
| 0005504 | |
| 0032869 | |
| 0002221 | |
| 0014823 | |
| 0042493 | |
| 0032355 | |
| 0060416 | |
| 0007584 |
| Rat chromosome position | 4q11 |
|---|
| Swiss-Prot Accession | A4D1B1 |
|---|---|
| P16671 | |
| Q13965 | |
| Q9BQA7 | |
| Q9BZM7 | |
| Q9BZM9 | |
| Q9BZN0 | |
| Q9BZN1 | |
| Q9BZN2 | |
| Q9BZN6 | |
| Q08857 | |
| Q3UAI3 | |
| Q8C6Z4 | |
| Q3UC79 | |
| Q3U6Y9 | |
| Q3TA14 | |
| Q9CT95 | |
| Q6IMX5 | |
| O35754 | |
| Q07969 | |
| Q794J1 | |
| Q5BKE5 | |
| Q13966 | |
| Q16093 | |
| Q8TCV7 | |
| Q9BPZ8 | |
| Q9BQC2 | |
| Q9BZM8 | |
| Q9BZN3 | |
| Q9BZN4 | |
| Q9BZN5 |
| PIR ID | I49590 |
|---|---|
| A54870 |
| Unigene ID | Hs.120949 |
|---|---|
| Mm.18628 | |
| Mm.406799 | |
| Rn.102418 | |
| Rn.205840 |
| KEGG ID | hsa:948 |
|---|---|
| mmu:12491 | |
| rno:29184 | |
| rno:499985 | |
| rno:685953 |
| Swiss-Prot ID | CD36_MOUSE |
|---|---|
| CD36_HUMAN | |
| Q3UAI3_MOUSE | |
| Q5BKE5_RAT | |
| Q3U6Y9_MOUSE | |
| Q8C6Z4_MOUSE | |
| Q6IMX5_RAT | |
| Q3UC79_MOUSE | |
| A4D1B1_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00331214 |
|---|---|
| IPI00418495 | |
| IPI00763638 | |
| IPI00781829 | |
| IPI00745287 | |
| IPI00231197 | |
| IPI00556921 | |
| IPI00765613 | |
| IPI00766856 |
| RGD ID | 2301 |
|---|
| MGI ID | 107899 |
|---|