| URN | urn:agi-llid:51426 |
|---|---|
| Connectivity | 15 |
| Name | Polk |
| Description | polymerase (DNA directed) kappa |
| Notes | External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | transferase activity |
|---|---|
| DNA binding | |
| damaged DNA binding | |
| metal ion binding | |
| magnesium ion binding | |
| zinc ion binding | |
| nucleotidyltransferase activity | |
| DNA-directed DNA polymerase activity |
| GO Cellular Component | nucleus |
|---|
| GO Biological Process | DNA replication |
|---|---|
| DNA repair | |
| response to DNA damage stimulus |
| Ariadne Ontology | DNA replication |
|---|---|
| DNA repair |
| Group | DNA replication |
|---|---|
| DNA repair | |
| DNA replication | |
| DNA repair | |
| response to DNA damage stimulus | |
| transferase activity | |
| DNA binding | |
| damaged DNA binding | |
| metal ion binding | |
| magnesium ion binding | |
| zinc ion binding | |
| nucleotidyltransferase activity | |
| DNA-directed DNA polymerase activity | |
| nucleus |
| MedScan ID | 51426 |
|---|
| Hugo ID | 9183 |
|---|
| Human chromosome position | 5q13 |
|---|
| LocusLink ID | 51426 |
|---|---|
| 27015 | |
| 171525 |
| Alias | DINP |
|---|---|
| POLQ | |
| DINB1 | |
| DNA polymerase kappa | |
| DINB protein | |
| DinB homolog 1 | |
| DNA damage-inducible protein b | |
| DNA-directed DNA polymerase kappa | |
| DINB | |
| dinb homolog 1 (e. coli) | |
| DinB homolog I | |
| DINB I | |
| DNA damage-inducible proetin b | |
| POLK | |
| polymerase (DNA directed) kappa |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605650 |
|---|
| Mouse chromosome position | 13 |
|---|
| GO ID | 0003887 |
|---|---|
| 0003684 | |
| 0046872 | |
| 0016779 | |
| 0016740 | |
| 0006281 | |
| 0006260 | |
| 0005634 | |
| 0003677 | |
| 0006974 | |
| 0000287 | |
| 0008270 |
| Rat chromosome position | 2q12 |
|---|
| Swiss-Prot Accession | Q9UBT6 |
|---|---|
| Q59G18 | |
| Q5Q9G5 | |
| Q5Q9G6 | |
| Q5Q9G7 | |
| Q5Q9G8 | |
| Q9QUG2 | |
| Q3UUL1 | |
| Q5Q9G9 | |
| Q5Q9H0 | |
| Q5Q9H1 | |
| Q5Q9H2 | |
| Q5Q9H3 | |
| Q5Q9H4 | |
| Q5Q9H5 | |
| Q5Q9H6 | |
| Q5Q9H7 | |
| Q5Q9H8 | |
| Q922H5 | |
| Q9CRV6 | |
| B2RYH3 | |
| Q8R253 | |
| Q7TPY7 | |
| B2RBD2 | |
| Q86VJ8 | |
| Q8IZY0 | |
| Q8IZY1 | |
| Q8NB30 | |
| Q96L01 | |
| Q96Q86 | |
| Q96Q87 | |
| Q9UHC5 |
| Unigene ID | Hs.724621 |
|---|---|
| Mm.89926 | |
| Rn.92419 |
| KEGG ID | hsa:51426 |
|---|---|
| mmu:27015 | |
| rno:171525 |
| EC Number | 2.7.7.7 |
|---|
| Swiss-Prot ID | POLK_MOUSE |
|---|---|
| POLK_HUMAN | |
| B2RYH3_RAT | |
| B2RBD2_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00131620 |
|---|---|
| IPI00462547 | |
| IPI00033151 | |
| IPI00218100 | |
| IPI00552440 | |
| IPI00552703 | |
| IPI00896747 | |
| IPI00874428 | |
| IPI00515442 | |
| IPI00896579 | |
| IPI00515462 | |
| IPI00515521 | |
| IPI00372895 | |
| IPI00782573 | |
| IPI00777177 | |
| IPI00777918 |
| Homologene ID | 32140 |
|---|
| RGD ID | 620058 |
|---|
| MGI ID | 1349767 |
|---|