| URN | urn:agi-llid:3979 |
|---|---|
| Connectivity | 22 |
| Name | Lig3 |
| Description | ligase III, DNA, ATP-dependent |
| Notes | This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| ligase activity | |
| DNA binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| zinc ion binding | |
| DNA ligase activity | |
| DNA ligase (ATP) activity |
| GO Cellular Component | intracellular |
|---|---|
| nucleoplasm | |
| nucleus |
| GO Biological Process | cell division |
|---|---|
| cell cycle | |
| spermatogenesis | |
| reciprocal meiotic recombination | |
| DNA replication | |
| DNA recombination | |
| DNA repair | |
| V(D)J recombination | |
| response to DNA damage stimulus |
| Ariadne Ontology | DNA repair |
|---|
| Group | DNA repair |
|---|---|
| cell division | |
| cell cycle | |
| spermatogenesis | |
| reciprocal meiotic recombination | |
| DNA replication | |
| DNA recombination | |
| DNA repair | |
| V(D)J recombination | |
| response to DNA damage stimulus | |
| nucleotide binding | |
| ligase activity | |
| DNA binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| zinc ion binding | |
| DNA ligase activity | |
| DNA ligase (ATP) activity | |
| intracellular | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 3979 |
|---|
| Hugo ID | 6600 |
|---|
| Human chromosome position | 17q11.2-q12 |
|---|
| LocusLink ID | 3979 |
|---|---|
| 3980 | |
| 16882 | |
| 303369 |
| Alias | LIG2 |
|---|---|
| DNA ligase 3 | |
| DNA ligase III | |
| ligase II, DNA, ATP-dependent | |
| polydeoxyribonucleotide synthase [ATP] 3 | |
| MGC78176 | |
| D11Wsu78e | |
| RP23-316C11.6 | |
| DNA ligase (ATP) 3 | |
| OTTMUSP00000000875 | |
| OTTMUSP00000000876 | |
| ligase III, DNA, ATP-dependent | |
| DNA segment, Chr 11, Wayne State University 78, expressed | |
| LIG3 | |
| ligase ii | |
| Polydeoxyribonucleotide synthase (ATP) III | |
| Polydeoxyribonucleotide synthetase (ATP) III |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600940 |
|---|
| Mouse chromosome position | 11 48.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0003677 | |
| 0003910 | |
| 0003909 | |
| 0016874 | |
| 0046872 | |
| 0000166 | |
| 0008270 | |
| 0006281 | |
| 0006260 | |
| 0033151 | |
| 0007049 | |
| 0051301 | |
| 0007131 | |
| 0007283 | |
| 0005622 | |
| 0005654 | |
| 0005634 | |
| 0006310 | |
| 0006974 | |
| 0000287 |
| Rat chromosome position | 10q26 |
|---|
| Swiss-Prot Accession | P49916 |
|---|---|
| Q96DF0 | |
| Q80ZH7 | |
| P97386 | |
| Q3TJN5 | |
| Q3U0I5 | |
| Q3U1F0 | |
| Q3UC82 | |
| Q5U2M4 | |
| Q16714 | |
| Q6NVK3 |
| PIR ID | I37292 |
|---|
| Unigene ID | Hs.100299 |
|---|---|
| Mm.277136 | |
| Mm.413071 | |
| Rn.203089 |
| KEGG ID | hsa:3980 |
|---|---|
| mmu:16882 | |
| rno:303369 |
| EC Number | 6.5.1.1 |
|---|
| Swiss-Prot ID | DNLI3_HUMAN |
|---|---|
| Q5U2M4_RAT | |
| Q80ZH7_MOUSE | |
| Q6NVK3_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00000156 |
|---|---|
| IPI00029081 | |
| IPI00565239 | |
| IPI00624787 | |
| IPI00124272 | |
| IPI00230471 | |
| IPI00874294 | |
| IPI00475313 | |
| IPI00370404 | |
| IPI00563728 | |
| IPI00782672 |
| Homologene ID | 32109 |
|---|
| RGD ID | 1309875 |
|---|
| MGI ID | 109152 |
|---|