| URN | urn:agi-llid:1643 |
|---|---|
| Connectivity | 64 |
| Name | Ddb2 |
| Description | damage-specific DNA binding protein 2, 48kDa |
| Notes | This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | DNA binding |
|---|---|
| damaged DNA binding | |
| ubiquitin-protein ligase activity |
| GO Cellular Component | protein complex |
|---|---|
| nucleoplasm | |
| nucleus |
| GO Biological Process | DNA repair |
|---|---|
| nucleotide-excision repair | |
| pyrimidine dimer repair | |
| nucleotide-excision repair, DNA damage removal | |
| protein polyubiquitination | |
| protein autoubiquitination | |
| modification-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| response to UV |
| Ariadne Ontology | DNA repair |
|---|
| Group | DNA repair |
|---|---|
| DNA repair | |
| nucleotide-excision repair | |
| pyrimidine dimer repair | |
| nucleotide-excision repair, DNA damage removal | |
| protein polyubiquitination | |
| protein autoubiquitination | |
| modification-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| response to UV | |
| DNA binding | |
| damaged DNA binding | |
| ubiquitin-protein ligase activity | |
| protein complex | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 1643 |
|---|
| Hugo ID | 2718 |
|---|
| Human chromosome position | 11p12-p11 |
|---|
| LocusLink ID | 1643 |
|---|---|
| 107986 |
| Alias | DDBB |
|---|---|
| UV-DDB2 | |
| FLJ34321 | |
| DNA damage-binding protein 2 | |
| UV-DDB 2 | |
| DDB p48 subunit | |
| UV-damaged DNA-binding protein 2 | |
| damage-specific DNA-binding protein 2 | |
| xeroderma pigmentosum group E protein | |
| MGC117576 | |
| 2610043A19Rik | |
| RP23-20F9.8 | |
| OTTMUSP00000015309 | |
| OTTMUSP00000015310 | |
| 2610043A19 | |
| 48 kDa damage-specific DNA binding protein 2 | |
| 48 kDa damage-specific DNA binding protein II | |
| damage specific DNA binding protein 2 (48 kDa) | |
| Damage-specific DNA binding protein 2 | |
| damage-specific DNA binding protein 2 (48kD) | |
| Damage-specific DNA binding protein II | |
| Ddb2 | |
| DNA damage binding protein 2 | |
| DNA damage binding protein II | |
| LOC113427 | |
| LOC311186 | |
| UV- DDB 2 | |
| UV- DDB II | |
| UV-damaged DNA-binding protein II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 600811 |
|---|---|
| 278740 |
| Mouse chromosome position | 2 |
|---|
| GO ID | 0003677 |
|---|---|
| 0003684 | |
| 0004842 | |
| 0006281 | |
| 0006289 | |
| 0000718 | |
| 0051865 | |
| 0000209 | |
| 0006290 | |
| 0009411 | |
| 0005654 | |
| 0005634 | |
| 0043234 | |
| 0006974 | |
| 0019941 |
| Swiss-Prot Accession | Q92466 |
|---|---|
| A2AGR7 | |
| Q99J79 | |
| Q4FZK4 | |
| B2R875 | |
| Q76E54 | |
| Q76E55 | |
| Q76E56 | |
| Q76E57 |
| PIR ID | I38909 |
|---|
| Unigene ID | Hs.700338 |
|---|---|
| Mm.389334 |
| KEGG ID | hsa:1643 |
|---|---|
| mmu:107986 |
| Swiss-Prot ID | DDB2_MOUSE |
|---|---|
| DDB2_HUMAN | |
| A2AGR7_MOUSE | |
| B2R875_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00114927 |
|---|---|
| IPI00021518 | |
| IPI00446284 | |
| IPI00549348 | |
| IPI00607674 | |
| IPI00607727 | |
| IPI00649196 | |
| IPI00749745 |
| Homologene ID | 83 |
|---|
| RGD ID | 1310164 |
|---|
| MGI ID | 1355314 |
|---|