| URN | urn:agi-llid:1162 |
|---|---|
| Connectivity | 56 |
| Name | Ercc6 |
| Description | excision repair cross-complementing rodent repair deficiency, complementation group 6 |
| Notes | This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| chromatin binding | |
| hydrolase activity | |
| transcription elongation regulator activity | |
| protein N-terminus binding | |
| protein C-terminus binding | |
| protein complex binding | |
| DNA binding | |
| ATP binding | |
| helicase activity | |
| DNA helicase activity | |
| DNA-dependent ATPase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| nucleoplasm | |
| nucleolus | |
| transcription elongation factor complex | |
| nucleus |
| GO Biological Process | activation of JUN kinase activity |
|---|---|
| regulation of transcription | |
| positive regulation of RNA elongation | |
| activation of JNKK activity | |
| DNA damage response, signal transduction resulting in induction of apoptosis | |
| transcription from RNA polymerase II promoter | |
| DNA repair | |
| base-excision repair | |
| pyrimidine dimer repair | |
| transcription-coupled nucleotide-excision repair | |
| response to DNA damage stimulus | |
| response to oxidative stress | |
| response to toxin | |
| response to superoxide | |
| response to gamma radiation | |
| response to X-ray | |
| response to UV | |
| response to UV-B | |
| photoreceptor cell maintenance |
| Ariadne Ontology | Polymerase II transcription |
|---|---|
| DNA repair |
| Group | Polymerase II transcription |
|---|---|
| DNA repair | |
| activation of JUN kinase activity | |
| regulation of transcription | |
| positive regulation of RNA elongation | |
| activation of JNKK activity | |
| DNA damage response, signal transduction resulting in induction of apoptosis | |
| transcription from RNA polymerase II promoter | |
| DNA repair | |
| base-excision repair | |
| pyrimidine dimer repair | |
| transcription-coupled nucleotide-excision repair | |
| response to DNA damage stimulus | |
| response to oxidative stress | |
| response to toxin | |
| response to superoxide | |
| response to gamma radiation | |
| response to X-ray | |
| response to UV | |
| response to UV-B | |
| photoreceptor cell maintenance | |
| nucleotide binding | |
| chromatin binding | |
| hydrolase activity | |
| transcription elongation regulator activity | |
| protein N-terminus binding | |
| protein C-terminus binding | |
| protein complex binding | |
| DNA binding | |
| ATP binding | |
| helicase activity | |
| DNA helicase activity | |
| DNA-dependent ATPase activity | |
| soluble fraction | |
| nucleoplasm | |
| nucleolus | |
| transcription elongation factor complex | |
| nucleus |
| MedScan ID | 1162 |
|---|
| Hugo ID | 3438 |
|---|
| Human chromosome position | 10q11.23 |
|---|
| LocusLink ID | 1162 |
|---|---|
| 2074 | |
| 319955 | |
| 306274 |
| Alias | CSB |
|---|---|
| CKN2 | |
| COFS | |
| ARMD5 | |
| COFS1 | |
| RAD26 | |
| DNA excision repair protein ERCC-6 | |
| Rad26 homolog | |
| Cockayne syndrome B protein | |
| ATP-dependent helicase ERCC6 | |
| cockayne syndrome protein CSB | |
| Cockayne syndrome group B protein | |
| 4732403I04 | |
| C130058G22Rik | |
| CS group B correcting | |
| C130058G22 | |
| Cockayne syndrome 2 (late onset) | |
| cockayne syndrome group b gene | |
| cockayne syndrome II gene | |
| cockayne syndrome II protein | |
| CS group B correcting gene | |
| DNA repair helicase ERCC6 | |
| ERC6 | |
| ERC6_HUMAN | |
| ERCC VI | |
| Ercc6 | |
| ERCCVI | |
| excision repair 6 | |
| excision repair cross-complementing rodent repair deficiency, complementation group | |
| excision repair cross-complementing rodent repair deficiency, complementation group 6 | |
| Excision repair protein ERCC VI | |
| Excision repair protein ERCC-6 | |
| Excision repair protein ERCC-6 (Cockayne syndrome protein CSB) | |
| LOC282965 | |
| OTTHUMP00000019581 | |
| Rad26 (yeast) homolog |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609413 |
|---|---|
| 214150 | |
| 133540 | |
| 278800 | |
| 211980 | |
| 600630 |
| Mouse chromosome position | 14 |
|---|
| GO ID | 0005524 |
|---|---|
| 0003677 | |
| 0003678 | |
| 0008094 | |
| 0003682 | |
| 0016787 | |
| 0000166 | |
| 0008022 | |
| 0047485 | |
| 0032403 | |
| 0003711 | |
| 0008630 | |
| 0007256 | |
| 0007257 | |
| 0006284 | |
| 0045494 | |
| 0032786 | |
| 0006290 | |
| 0045449 | |
| 0009411 | |
| 0010224 | |
| 0010165 | |
| 0010332 | |
| 0006979 | |
| 0000303 | |
| 0009636 | |
| 0006366 | |
| 0006283 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0005625 | |
| 0008023 | |
| 0006281 | |
| 0006974 | |
| 0004386 |
| Rat chromosome position | 16p16 |
|---|
| Swiss-Prot Accession | Q03468 |
|---|---|
| Q59FF6 | |
| Q8C851 | |
| Q5W0L9 | |
| D3DX94 |
| PIR ID | A44224 |
|---|
| Unigene ID | Hs.654449 |
|---|---|
| Mm.318310 | |
| Rn.19370 |
| KEGG ID | hsa:2074 |
|---|---|
| mmu:319955 | |
| rno:306274 |
| EC Number | 3.6.1.- |
|---|
| Swiss-Prot ID | ERCC6_HUMAN |
|---|---|
| D3DX94_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00414779 |
|---|---|
| IPI00844131 | |
| IPI00555651 | |
| IPI00606873 | |
| IPI00358023 | |
| IPI00781961 |
| Homologene ID | 6279 |
|---|
| RGD ID | 1311509 |
|---|
| MGI ID | 1100494 |
|---|