| URN | urn:agi-llid:2072 |
|---|---|
| Connectivity | 12 |
| Name | Ercc4 |
| Description | excision repair cross-complementing rodent repair deficiency, complementation group 4 |
| Notes | The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6). |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | nucleic acid binding |
|---|---|
| hydrolase activity | |
| protein N-terminus binding | |
| protein C-terminus binding | |
| DNA binding | |
| damaged DNA binding | |
| structure-specific DNA binding | |
| single-stranded DNA binding | |
| magnesium ion binding | |
| nuclease activity | |
| endonuclease activity | |
| endodeoxyribonuclease activity |
| GO Cellular Component | chromosome, telomeric region |
|---|---|
| nucleoplasm | |
| nucleotide-excision repair complex | |
| nuclear chromosome, telomeric region | |
| nucleus |
| GO Biological Process | negative regulation of telomere maintenance |
|---|---|
| DNA metabolic process | |
| nucleotide-excision repair, DNA incision | |
| telomere maintenance | |
| DNA repair | |
| nucleotide-excision repair, DNA incision, 3'-to lesion | |
| nucleotide-excision repair, DNA incision, 5'-to lesion | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| telomere maintenance via telomere shortening | |
| double-strand break repair via homologous recombination | |
| response to DNA damage stimulus | |
| response to UV | |
| UV protection |
| Ariadne Ontology | DNA repair |
|---|
| Group | DNA repair |
|---|---|
| negative regulation of telomere maintenance | |
| DNA metabolic process | |
| nucleotide-excision repair, DNA incision | |
| telomere maintenance | |
| DNA repair | |
| nucleotide-excision repair, DNA incision, 3'-to lesion | |
| nucleotide-excision repair, DNA incision, 5'-to lesion | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| telomere maintenance via telomere shortening | |
| double-strand break repair via homologous recombination | |
| response to DNA damage stimulus | |
| response to UV | |
| UV protection | |
| nucleic acid binding | |
| hydrolase activity | |
| protein N-terminus binding | |
| protein C-terminus binding | |
| DNA binding | |
| damaged DNA binding | |
| structure-specific DNA binding | |
| single-stranded DNA binding | |
| magnesium ion binding | |
| nuclease activity | |
| endonuclease activity | |
| endodeoxyribonuclease activity | |
| chromosome, telomeric region | |
| nucleoplasm | |
| nucleotide-excision repair complex | |
| nuclear chromosome, telomeric region | |
| nucleus |
| MedScan ID | 2072 |
|---|
| Hugo ID | 3436 |
|---|
| Human chromosome position | 16p13.12 |
|---|
| LocusLink ID | 2072 |
|---|---|
| 50505 | |
| 304719 |
| Alias | XPF |
|---|---|
| RAD1 | |
| ERCC11 | |
| DNA repair endonuclease XPF | |
| OTTHUMP00000045868 | |
| DNA excision repair protein ERCC-4 | |
| DNA repair protein complementing XP-F cells | |
| xeroderma pigmentosum, complementation group F | |
| xeroderma pigmentosum group F-complementing protein | |
| excision-repair, complementing defective, in Chinese hamster | |
| AI606920 | |
| OTTMUSP00000028967 | |
| OTTMUSP00000028969 | |
| DNA repair endonuclease subunit | |
| RGD1560340 | |
| excision repair cross-complementing rodent repair deficiency, complementation group 4 | |
| DNA excision repair protein ERCC IV | |
| DNA-repair protein complementing XP-F cell | |
| Ercc4 | |
| LOC161866 | |
| LOC197172 | |
| LOC683847 | |
| Xeroderma pigmentosum group F complementing protein | |
| xeroderma pigmentosum, complementing group F |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 133520 |
|---|---|
| 278760 | |
| 610965 |
| Mouse chromosome position | 16 |
|---|
| GO ID | 0003684 |
|---|---|
| 0004520 | |
| 0016787 | |
| 0008022 | |
| 0047485 | |
| 0003697 | |
| 0043566 | |
| 0006281 | |
| 0009650 | |
| 0000724 | |
| 0032205 | |
| 0006289 | |
| 0000718 | |
| 0033683 | |
| 0006295 | |
| 0006296 | |
| 0009411 | |
| 0000723 | |
| 0010834 | |
| 0000781 | |
| 0000784 | |
| 0005654 | |
| 0000109 | |
| 0005634 | |
| 0003677 | |
| 0004519 | |
| 0004518 | |
| 0003676 | |
| 0006259 | |
| 0006974 | |
| 0000287 |
| Rat chromosome position | 10q11 |
|---|
| Swiss-Prot Accession | Q92889 |
|---|---|
| Q3UEU6 | |
| Q9QZD4 | |
| Q3UUC1 | |
| Q9CXC7 | |
| A8K111 | |
| O00140 | |
| Q8TD83 | |
| O54810 | |
| Q8R0I3 |
| Unigene ID | Hs.567265 |
|---|---|
| Mm.287837 |
| KEGG ID | hsa:2072 |
|---|---|
| mmu:50505 | |
| rno:304719 |
| EC Number | 3.1.-.- |
|---|
| Swiss-Prot ID | XPF_HUMAN |
|---|---|
| XPF_MOUSE | |
| Q3UEU6_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00219179 |
|---|---|
| IPI00137263 | |
| IPI00657932 | |
| IPI00461363 | |
| IPI00856677 | |
| IPI00857198 | |
| IPI00371802 |
| Homologene ID | 3836 |
|---|
| RGD ID | 1560340 |
|---|
| MGI ID | 1354163 |
|---|