| URN | urn:agi-llid:2071 |
|---|---|
| Connectivity | 58 |
| Name | Ercc3 |
| Description | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) |
| Notes | ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| peptide binding | |
| nucleic acid binding | |
| hydrolase activity | |
| protein N-terminus binding | |
| transcription factor binding | |
| protein C-terminus binding | |
| DNA binding | |
| ATP binding | |
| dATP binding | |
| GTP binding | |
| damaged DNA binding | |
| protein kinase activity | |
| RNA polymerase II carboxy-terminal domain kinase activity | |
| helicase activity | |
| ATPase activity | |
| DNA-dependent ATPase activity | |
| ATP-dependent DNA helicase activity | |
| 3'-5' DNA helicase activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| holo TFIIH complex | |
| nucleus | |
| SSL2-core TFIIH complex |
| GO Biological Process | interspecies interaction between organisms |
|---|---|
| hair cell differentiation | |
| DNA topological change | |
| cell cycle checkpoint | |
| regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| induction of apoptosis | |
| ATP catabolic process | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| nucleotide-excision repair, DNA incision | |
| DNA repair | |
| RNA elongation from RNA polymerase II promoter | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| transcription-coupled nucleotide-excision repair | |
| protein amino acid phosphorylation | |
| nucleotide-excision repair, DNA duplex unwinding | |
| response to DNA damage stimulus | |
| response to oxidative stress | |
| response to hypoxia | |
| response to UV | |
| UV protection | |
| transcription initiation from RNA polymerase II promoter | |
| protein localization |
| Ariadne Ontology | Glucose metabolism |
|---|---|
| Polymerase II transcription | |
| DNA repair |
| Group | Glucose metabolism |
|---|---|
| Polymerase II transcription | |
| DNA repair | |
| interspecies interaction between organisms | |
| hair cell differentiation | |
| DNA topological change | |
| cell cycle checkpoint | |
| regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| induction of apoptosis | |
| ATP catabolic process | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| nucleotide-excision repair, DNA incision | |
| DNA repair | |
| RNA elongation from RNA polymerase II promoter | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| transcription-coupled nucleotide-excision repair | |
| protein amino acid phosphorylation | |
| nucleotide-excision repair, DNA duplex unwinding | |
| response to DNA damage stimulus | |
| response to oxidative stress | |
| response to hypoxia | |
| response to UV | |
| UV protection | |
| transcription initiation from RNA polymerase II promoter | |
| protein localization | |
| nucleotide binding | |
| peptide binding | |
| nucleic acid binding | |
| hydrolase activity | |
| protein N-terminus binding | |
| transcription factor binding | |
| protein C-terminus binding | |
| DNA binding | |
| ATP binding | |
| dATP binding | |
| GTP binding | |
| damaged DNA binding | |
| protein kinase activity | |
| RNA polymerase II carboxy-terminal domain kinase activity | |
| helicase activity | |
| ATPase activity | |
| DNA-dependent ATPase activity | |
| ATP-dependent DNA helicase activity | |
| 3'-5' DNA helicase activity | |
| nucleoplasm | |
| holo TFIIH complex | |
| nucleus | |
| SSL2-core TFIIH complex |
| MedScan ID | 2071 |
|---|
| Hugo ID | 3435 |
|---|
| Human chromosome position | 2q21 |
|---|
| LocusLink ID | 2071 |
|---|---|
| 13872 | |
| 291703 |
| Alias | XPB |
|---|---|
| BTF2 | |
| GTF2H | |
| RAD25 | |
| TFIIH | |
| TFIIH basal transcription factor complex helicase XPB subunit | |
| BTF2 p89 | |
| TFIIH p89 | |
| TFIIH 89 kDa subunit | |
| DNA excision repair protein ERCC-3 | |
| DNA repair protein complementing XP-B cells | |
| basic transcription factor 2 89 kDa subunit | |
| xeroderma pigmentosum, complementation group B | |
| xeroderma pigmentosum group B-complementing protein | |
| TFIIH basal transcription factor complex 89 kDa subunit | |
| Ercc-3 | |
| BTF2-p89 | |
| excision repair 3 | |
| OTTMUSP00000028389 | |
| MGC112916 | |
| Xpbc | |
| complementation group 3 | |
| complementation group III | |
| DNA excision repair protein ERCC III | |
| DNA-repair protein complementing XP-B cells | |
| Ercc3 | |
| excision repair cross-complementing rodent repair deficiency, complementation group 3 | |
| excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | |
| excision repair III | |
| Excision-repair cross-complementing rodent repair deficiency | |
| OTTHUMP00000162265 | |
| TFIIH-p89 | |
| Xeroderma pigmentosum group B complementing protein | |
| xeroderma pigmentosum, complementing group B | |
| XPB_HUMAN | |
| XPBC/ERCC-3 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 133510 |
|---|---|
| 601675 | |
| 610651 |
| Mouse chromosome position | 18 |
|---|
| GO ID | 0043138 |
|---|---|
| 0005524 | |
| 0004003 | |
| 0016887 | |
| 0003677 | |
| 0008094 | |
| 0005525 | |
| 0008353 | |
| 0032564 | |
| 0003684 | |
| 0004386 | |
| 0016787 | |
| 0000166 | |
| 0042277 | |
| 0008022 | |
| 0047485 | |
| 0004672 | |
| 0008134 | |
| 0006281 | |
| 0006265 | |
| 0006368 | |
| 0009650 | |
| 0000075 | |
| 0035315 | |
| 0006917 | |
| 0044419 | |
| 0006289 | |
| 0000718 | |
| 0000717 | |
| 0033683 | |
| 0045944 | |
| 0006468 | |
| 0008104 | |
| 0045449 | |
| 0009411 | |
| 0001666 | |
| 0006979 | |
| 0006366 | |
| 0006367 | |
| 0006283 | |
| 0000441 | |
| 0005675 | |
| 0005654 | |
| 0005634 | |
| 0003676 | |
| 0006200 | |
| 0006974 | |
| 0006350 |
| Rat chromosome position | 18p12 |
|---|
| Swiss-Prot Accession | P19447 |
|---|---|
| Q53QM0 | |
| Q53HW5 | |
| P49135 | |
| Q3TVD8 | |
| Q3U3I5 | |
| Q8R1K9 | |
| Q4G005 |
| PIR ID | A48994 |
|---|---|
| A35661 |
| Unigene ID | Hs.469872 |
|---|---|
| Mm.282335 | |
| Rn.44012 |
| KEGG ID | hsa:2071 |
|---|---|
| mmu:13872 | |
| rno:291703 |
| EC Number | 3.6.1.- |
|---|
| Swiss-Prot ID | ERCC3_MOUSE |
|---|---|
| ERCC3_RAT | |
| ERCC3_HUMAN | |
| Q53QM0_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00113070 |
|---|---|
| IPI00363457 | |
| IPI00747053 |
| Homologene ID | 96 |
|---|
| RGD ID | 1307139 |
|---|
| MGI ID | 95414 |
|---|