| URN | urn:agi-llid:7507 |
|---|---|
| Connectivity | 73 |
| Name | Xpa |
| Description | xeroderma pigmentosum, complementation group A |
| Notes | This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| protein domain specific binding | |
| DNA binding | |
| protein homodimerization activity | |
| damaged DNA binding | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleus |
| GO Biological Process | DNA damage response, signal transduction resulting in induction of apoptosis |
|---|---|
| DNA repair | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| response to DNA damage stimulus | |
| response to oxidative stress | |
| response to toxin | |
| response to UV |
| Ariadne Ontology | DNA repair |
|---|
| Group | DNA repair |
|---|---|
| DNA damage response, signal transduction resulting in induction of apoptosis | |
| DNA repair | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| response to DNA damage stimulus | |
| response to oxidative stress | |
| response to toxin | |
| response to UV | |
| nucleotide binding | |
| protein domain specific binding | |
| DNA binding | |
| protein homodimerization activity | |
| damaged DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 7507 |
|---|
| Hugo ID | 12814 |
|---|
| Human chromosome position | 9q22.3 |
|---|
| LocusLink ID | 7507 |
|---|---|
| 22590 | |
| 298074 |
| Alias | XP1 |
|---|---|
| XPAC | |
| DNA repair protein complementing XP-A cells | |
| excision repair-controlling | |
| xeroderma pigmentosum group A-complementing protein | |
| AI573865 | |
| RP23-423O7.1 | |
| DNA repair protein complementing XP-A cells homolog | |
| OTTMUSP00000007309 | |
| OTTMUSP00000007311 | |
| xeroderma pigmentosum group A-complementing protein homolog | |
| xeroderma pigmentosum, complementation group A | |
| DNA-repair protein complementing XP-A cells | |
| excision repair-controlling gene XPAC | |
| OTTHUMP00000021751 | |
| Xeroderma pigmentosum A | |
| xeroderma pigmentosum group A | |
| Xeroderma pigmentosum group A complementing protein | |
| xeroderma pigmentosum, complementing group A | |
| XP I | |
| XPA |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 611153 |
|---|---|
| 278700 |
| Mouse chromosome position | 4 21.5 cM |
|---|
| GO ID | 0003684 |
|---|---|
| 0046872 | |
| 0000166 | |
| 0019904 | |
| 0042803 | |
| 0008630 | |
| 0006281 | |
| 0000718 | |
| 0009411 | |
| 0006979 | |
| 0009636 | |
| 0005654 | |
| 0005634 | |
| 0003677 | |
| 0006289 | |
| 0006974 | |
| 0008270 |
| Rat chromosome position | 5q22 |
|---|
| Swiss-Prot Accession | P23025 |
|---|---|
| Q64267 | |
| Q8K2X7 | |
| Q8R4W5 | |
| Q5T1U9 | |
| Q6LCW7 | |
| Q6LD02 | |
| A2ALZ7 | |
| Q9CVA0 |
| PIR ID | I38886 |
|---|---|
| JG0190 | |
| S41498 |
| Unigene ID | Hs.654364 |
|---|---|
| Mm.247036 | |
| Rn.12469 |
| KEGG ID | hsa:7507 |
|---|---|
| mmu:22590 | |
| rno:298074 |
| Swiss-Prot ID | XPA_HUMAN |
|---|---|
| XPA_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00009694 |
|---|---|
| IPI00132269 | |
| IPI00461145 | |
| IPI00515066 | |
| IPI00462915 | |
| IPI00875397 | |
| IPI00170021 | |
| IPI00205657 | |
| IPI00205862 |
| Homologene ID | 37298 |
|---|
| RGD ID | 1308769 |
|---|
| MGI ID | 99135 |
|---|