| URN | urn:agi-llid:5887 |
|---|---|
| Connectivity | 51 |
| Name | Rad23b |
| Description | RAD23 homolog B (S. cerevisiae) |
| Notes | The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | damaged DNA binding |
|---|---|
| single-stranded DNA binding |
| GO Cellular Component | cytoplasm |
|---|---|
| proteasome complex | |
| nucleoplasm | |
| nucleus |
| GO Biological Process | spermatogenesis |
|---|---|
| DNA repair | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| response to DNA damage stimulus |
| Ariadne Ontology | DNA repair |
|---|
| Group | DNA repair |
|---|---|
| spermatogenesis | |
| DNA repair | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| damaged DNA binding | |
| single-stranded DNA binding | |
| cytoplasm | |
| proteasome complex | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 5887 |
|---|
| Hugo ID | 9813 |
|---|
| Human chromosome position | 9q31.2 |
|---|
| LocusLink ID | 5887 |
|---|---|
| 19359 | |
| 298012 |
| Alias | P58 |
|---|---|
| HR23B | |
| HHR23B | |
| RP11-131A5.1 | |
| UV excision repair protein RAD23 homolog B | |
| RAD23, yeast homolog of, B | |
| XP-C repair complementing protein | |
| XP-C repair complementing complex 58 kDa | |
| XP-C repair-complementing complex 58 kDa protein | |
| mHR23B | |
| AV001138 | |
| 0610007D13Rik | |
| RP23-120N11.1 | |
| OTTMUSP00000007676 | |
| MGC112630 | |
| RAD23b homolog | |
| 0610007D13 | |
| LOC138514 | |
| OTTHUMP00000021857 | |
| RAD23 B | |
| RAD23 homolog B | |
| RAD23 homolog B (S. cerevisiae) | |
| RAD23b homolog (S. cerevisiae) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600062 |
|---|
| Mouse chromosome position | 4 |
|---|
| GO ID | 0003684 |
|---|---|
| 0003697 | |
| 0006289 | |
| 0000718 | |
| 0043161 | |
| 0007283 | |
| 0005737 | |
| 0005654 | |
| 0005634 | |
| 0000502 | |
| 0006281 | |
| 0006974 |
| Rat chromosome position | 5q24 |
|---|
| Swiss-Prot Accession | P54727 |
|---|---|
| Q53F10 | |
| Q5W0S4 | |
| Q5W0S5 | |
| Q7Z5K8 | |
| Q3TUA4 | |
| Q3UQN3 | |
| P54728 | |
| Q3TJ52 | |
| Q3TQQ6 | |
| Q3U041 | |
| Q6NVC3 | |
| Q4KMA2 | |
| B3KWK8 | |
| Q8WUB0 | |
| Q0D2G8 | |
| Q5CZZ8 | |
| Q6IRD5 |
| PIR ID | S44346 |
|---|
| Unigene ID | Hs.521640 |
|---|---|
| Mm.196846 | |
| Rn.67042 |
| KEGG ID | hsa:5887 |
|---|---|
| mmu:19359 | |
| rno:298012 |
| Swiss-Prot ID | RD23B_HUMAN |
|---|---|
| RD23B_RAT | |
| Q3UQN3_MOUSE | |
| Q3TUA4_MOUSE | |
| B3KWK8_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00008223 |
|---|---|
| IPI00210495 | |
| IPI00890867 | |
| IPI00642549 | |
| IPI00479614 | |
| IPI00643078 | |
| IPI00108774 | |
| IPI00652022 |
| Homologene ID | 37704 |
|---|
| RGD ID | 1562958 |
|---|
| MGI ID | 105128 |
|---|