| URN | urn:agi-llid:2073 |
|---|---|
| Connectivity | 12 |
| Name | Ercc5 |
| Description | excision repair cross-complementing rodent repair deficiency, complementation group 5 |
| Notes | Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cause Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been described, but the biological validity of all variants has not been determined. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| protein N-terminus binding | |
| DNA binding | |
| protein homodimerization activity | |
| double-stranded DNA binding | |
| single-stranded DNA binding | |
| bubble DNA binding | |
| metal ion binding | |
| magnesium ion binding | |
| nuclease activity | |
| endonuclease activity | |
| endodeoxyribonuclease activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| DNA-directed RNA polymerase II, holoenzyme | |
| holo TFIIH complex | |
| nucleus |
| GO Biological Process | multicellular organism growth |
|---|---|
| determination of adult lifespan | |
| negative regulation of apoptosis | |
| DNA repair | |
| nucleotide-excision repair, DNA incision, 3'-to lesion | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| transcription-coupled nucleotide-excision repair | |
| response to DNA damage stimulus | |
| response to UV | |
| UV protection | |
| response to UV-C |
| Ariadne Ontology | DNA repair |
|---|
| Group | DNA repair |
|---|---|
| catalytic activity | |
| multicellular organism growth | |
| determination of adult lifespan | |
| negative regulation of apoptosis | |
| DNA repair | |
| nucleotide-excision repair, DNA incision, 3'-to lesion | |
| nucleotide-excision repair | |
| nucleotide-excision repair, DNA damage removal | |
| transcription-coupled nucleotide-excision repair | |
| response to DNA damage stimulus | |
| response to UV | |
| UV protection | |
| response to UV-C | |
| hydrolase activity | |
| protein N-terminus binding | |
| DNA binding | |
| protein homodimerization activity | |
| double-stranded DNA binding | |
| single-stranded DNA binding | |
| bubble DNA binding | |
| metal ion binding | |
| magnesium ion binding | |
| nuclease activity | |
| endonuclease activity | |
| endodeoxyribonuclease activity | |
| nucleoplasm | |
| DNA-directed RNA polymerase II, holoenzyme | |
| holo TFIIH complex | |
| nucleus |
| MedScan ID | 2073 |
|---|
| Hugo ID | 3437 |
|---|
| Human chromosome position | 13q33 |
|---|
| LocusLink ID | 2073 |
|---|---|
| 22592 | |
| 301382 |
| Alias | XPG |
|---|---|
| UVDR | |
| XPGC | |
| COFS3 | |
| ERCM2 | |
| RP11-484I6.5 | |
| DNA repair protein complementing XP-G cells | |
| excision repair protein | |
| XPG-complementing protein | |
| DNA excision repair protein ERCC-5 | |
| xeroderma pigmentosum, complementation group G | |
| xeroderma pigmentosum group G-complementing protein | |
| xeroderma pigmentosum complementation group G protein | |
| MGC176031 | |
| DNA repair protein complementing XP-G cells homolog | |
| OTTMUSP00000023812 | |
| xeroderma pigmentosum group G-complementing protein homolog | |
| excision repair cross-complementing rodent repair deficiency, complementation group 5 | |
| complementation group 5 | |
| complementation group V | |
| DNA excision repair protein ERCC V | |
| DNA repair XPGC | |
| DNA-repair protein complementing XP-G cells | |
| ERCC5 | |
| Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum complementation group G (Cockayne syndrome)) | |
| OTTHUMP00000064902 | |
| xeroderma pigmentosum complementing group G | |
| Xeroderma pigmentosum group G complementing protein | |
| XPG_HUMAN |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 133530 |
|---|---|
| 214150 | |
| 278780 |
| Mouse chromosome position | 1 26.6 cM |
|---|
| GO ID | 0003677 |
|---|---|
| 0000405 | |
| 0003690 | |
| 0004520 | |
| 0004519 | |
| 0016787 | |
| 0046872 | |
| 0047485 | |
| 0042803 | |
| 0003697 | |
| 0009650 | |
| 0008340 | |
| 0035264 | |
| 0043066 | |
| 0000718 | |
| 0006295 | |
| 0009411 | |
| 0010225 | |
| 0006283 | |
| 0016591 | |
| 0005675 | |
| 0005654 | |
| 0005634 | |
| 0003824 | |
| 0004518 | |
| 0006281 | |
| 0006289 | |
| 0006974 | |
| 0000287 |
| Rat chromosome position | 9q22 |
|---|
| Swiss-Prot Accession | P28715 |
|---|---|
| Q9HD60 | |
| Q9NR54 | |
| Q3UV64 | |
| P35689 | |
| Q3TPQ3 | |
| Q3TUN4 | |
| Q3TUT3 | |
| Q6P9Q0 | |
| Q8CAG2 | |
| A6NGT4 | |
| Q5JUS4 | |
| Q5JUS5 | |
| Q7Z2V3 | |
| Q8IZL6 | |
| Q8N1B7 | |
| Q9HD59 |
| PIR ID | I58009 |
|---|---|
| S35993 |
| Unigene ID | Hs.258429 |
|---|---|
| Mm.2213 | |
| Rn.208330 |
| KEGG ID | hsa:2073 |
|---|---|
| mmu:22592 | |
| rno:301382 |
| EC Number | 3.1.-.- |
|---|
| Swiss-Prot ID | ERCC5_HUMAN |
|---|---|
| Q3UV64_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00477535 |
|---|---|
| IPI00640241 | |
| IPI00875692 | |
| IPI00848102 | |
| IPI00005267 | |
| IPI00552845 | |
| IPI00310463 | |
| IPI00460333 | |
| IPI00408780 | |
| IPI00357888 | |
| IPI00777181 | |
| IPI00763212 |
| Homologene ID | 37265 |
|---|
| RGD ID | 1586176 |
|---|
| MGI ID | 103582 |
|---|