| URN | urn:agi-llid:3978 |
|---|---|
| Connectivity | 50 |
| Name | Lig1 |
| Description | ligase I, DNA, ATP-dependent |
| Notes | LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. |
| Pathway | mismatch repair pathway |
|---|---|
| nucleotide excision repair pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| ligase activity | |
| DNA binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| DNA ligase activity | |
| DNA ligase (ATP) activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleus |
| GO Biological Process | cell division |
|---|---|
| cell cycle | |
| anatomical structure morphogenesis | |
| DNA metabolic process | |
| DNA replication | |
| DNA recombination | |
| DNA repair | |
| nucleotide-excision repair, DNA gap filling | |
| V(D)J recombination | |
| response to DNA damage stimulus |
| Ariadne Ontology | DNA replication |
|---|---|
| DNA repair |
| Group | DNA replication |
|---|---|
| DNA repair | |
| cell division | |
| cell cycle | |
| anatomical structure morphogenesis | |
| DNA metabolic process | |
| DNA replication | |
| DNA recombination | |
| DNA repair | |
| nucleotide-excision repair, DNA gap filling | |
| V(D)J recombination | |
| response to DNA damage stimulus | |
| nucleotide binding | |
| ligase activity | |
| DNA binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| DNA ligase activity | |
| DNA ligase (ATP) activity | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 3978 |
|---|
| Hugo ID | 6598 |
|---|
| Human chromosome position | 19q13.2-q13.3 |
|---|
| LocusLink ID | 3978 |
|---|---|
| 16881 | |
| 81513 |
| Alias | MGC117397 |
|---|---|
| MGC130025 | |
| DNA ligase 1 | |
| polydeoxyribonucleotide synthase ATP 1 | |
| polydeoxyribonucleotide synthase [ATP] 1 | |
| LigI | |
| AL033288 | |
| DNA ligase I | |
| OTTMUSP00000039904 | |
| OTTMUSP00000039906 | |
| OTTMUSP00000039908 | |
| OTTMUSP00000039911 | |
| MGC105416 | |
| DNA ligase (ATP) 1 | |
| Lig-1 | |
| LIG I | |
| LIG1 | |
| ligase I, DNA, ATP-dependent | |
| mLigI | |
| Polydeoxyribonucleotide synthase (ATP) I | |
| Polydeoxyribonucleotide synthetase (ATP) I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 126391 |
|---|
| Mouse chromosome position | 7 4.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0003677 | |
| 0003910 | |
| 0003909 | |
| 0016874 | |
| 0046872 | |
| 0000166 | |
| 0006259 | |
| 0006310 | |
| 0006281 | |
| 0006260 | |
| 0033151 | |
| 0009653 | |
| 0007049 | |
| 0051301 | |
| 0006297 | |
| 0005654 | |
| 0005634 | |
| 0006974 | |
| 0000287 | |
| 0005575 |
| Rat chromosome position | 1q21 |
|---|
| Swiss-Prot Accession | P18858 |
|---|---|
| Q2TB12 | |
| Q59HG7 | |
| Q76GR4 | |
| Q3U4X8 | |
| P37913 | |
| Q3TSU8 | |
| Q8BPJ2 | |
| Q8R055 | |
| Q566D8 | |
| Q9JHY8 | |
| B2RAI8 | |
| Q32P23 |
| PIR ID | I48921 |
|---|---|
| A36048 |
| Unigene ID | Hs.1770 |
|---|---|
| Mm.288179 | |
| Mm.421129 | |
| Rn.20467 |
| KEGG ID | hsa:3978 |
|---|---|
| mmu:16881 | |
| rno:81513 |
| EC Number | 6.5.1.1 |
|---|
| Swiss-Prot ID | DNLI1_RAT |
|---|---|
| DNLI1_MOUSE | |
| DNLI1_HUMAN | |
| Q3U4X8_MOUSE | |
| Q566D8_RAT | |
| Q3TSU8_MOUSE | |
| B2RAI8_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00200072 |
|---|---|
| IPI00473314 | |
| IPI00219841 | |
| IPI00553920 | |
| IPI00885652 | |
| IPI00885719 | |
| IPI00885973 |
| Homologene ID | 197 |
|---|
| RGD ID | 621424 |
|---|
| MGI ID | 101789 |
|---|