| URN | urn:agi-llid:7515 |
|---|---|
| Connectivity | 99 |
| Name | Xrcc1 |
| Description | X-ray repair complementing defective repair in Chinese hamster cells 1 |
| Notes | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq] |
| Pathway | nucleotide excision repair pathway |
|---|
| GO Molecular Function | damaged DNA binding |
|---|
| GO Cellular Component | intracellular |
|---|---|
| nucleoplasm | |
| nucleus |
| GO Biological Process | DNA repair |
|---|---|
| single strand break repair | |
| base-excision repair | |
| response to DNA damage stimulus | |
| response to organic substance | |
| response to drug | |
| response to hypoxia |
| Ariadne Ontology | DNA repair |
|---|
| Group | DNA repair |
|---|---|
| DNA repair | |
| single strand break repair | |
| base-excision repair | |
| response to DNA damage stimulus | |
| response to organic substance | |
| response to drug | |
| response to hypoxia | |
| damaged DNA binding | |
| intracellular | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 7515 |
|---|
| Hugo ID | 12828 |
|---|
| Human chromosome position | 19q13.2 |
|---|
| LocusLink ID | 7515 |
|---|---|
| 22594 | |
| 84495 |
| Alias | RCC |
|---|---|
| DNA repair protein XRCC1 | |
| X-ray repair cross-complementing protein 1 | |
| X-ray-repair, complementing defective, repair in Chinese hamster | |
| Xrcc-1 | |
| MGC102556 | |
| x-ray repair cross-complementing group 1 protein | |
| DNA-repair protein XRCC I | |
| X-ray repair complementing defective repair in Chinese hamster cells 1 | |
| X-ray repair complementing defective repair in Chinese hamster cells I | |
| X-ray repair cross complementing protein 1 | |
| X-ray repair cross complementing protein I | |
| Xrcc I | |
| Xrcc1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 194360 |
|---|
| Mouse chromosome position | 7 5.5 cM |
|---|
| GO ID | 0003684 |
|---|---|
| 0042493 | |
| 0001666 | |
| 0010033 | |
| 0000012 | |
| 0005622 | |
| 0005654 | |
| 0005634 | |
| 0006281 | |
| 0006974 | |
| 0006284 |
| Rat chromosome position | 1q21 |
|---|
| Swiss-Prot Accession | B2RCY5 |
|---|---|
| P18887 | |
| Q59HH7 | |
| Q3TGI0 | |
| Q60596 | |
| Q3TN28 | |
| Q3U2B4 | |
| Q8BQS1 | |
| Q9ESZ0 | |
| Q6IBS4 | |
| Q9HCB1 | |
| Q3THC5 | |
| Q5U435 | |
| Q7TNQ5 | |
| Q6IRJ9 |
| PIR ID | A36353 |
|---|---|
| A54659 |
| Unigene ID | Hs.98493 |
|---|---|
| Mm.4347 | |
| Rn.13754 |
| KEGG ID | hsa:7515 |
|---|---|
| mmu:22594 | |
| rno:84495 |
| Swiss-Prot ID | XRCC1_HUMAN |
|---|---|
| XRCC1_MOUSE | |
| XRCC1_RAT | |
| Q59HH7_HUMAN | |
| B2RCY5_HUMAN | |
| Q3TGI0_MOUSE | |
| Q6IBS4_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00002564 |
|---|---|
| IPI00118139 | |
| IPI00421930 | |
| IPI00880055 | |
| IPI00879881 | |
| IPI00458406 |
| Homologene ID | 31368 |
|---|
| RGD ID | 619823 |
|---|
| MGI ID | 99137 |
|---|