| URN | urn:agi-llid:5111 |
|---|---|
| Connectivity | 583 |
| Name | Pcna |
| Description | proliferating cell nuclear antigen |
| Notes | The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. |
| Pathway | mismatch repair pathway |
|---|---|
| nucleotide excision repair pathway |
| GO Molecular Function | DNA polymerase processivity factor activity |
|---|---|
| DNA binding | |
| MutLalpha complex binding | |
| dinucleotide insertion or deletion binding | |
| purine-specific mismatch base pair DNA N-glycosylase activity |
| GO Cellular Component | PCNA complex |
|---|---|
| cyclin-dependent protein kinase holoenzyme complex | |
| DNA replication factor C complex | |
| replication fork | |
| nucleoplasm | |
| PCNA-p21 complex | |
| nuclear lamina | |
| nuclear replication fork | |
| nucleus |
| GO Biological Process | cell proliferation |
|---|---|
| heart development | |
| phosphoinositide-mediated signaling | |
| regulation of DNA replication | |
| DNA replication | |
| translesion synthesis | |
| base-excision repair, gap-filling | |
| DNA repair | |
| nucleotide-excision repair, DNA gap filling | |
| mismatch repair | |
| response to lipid | |
| response to cadmium ion | |
| intracellular protein transport |
| Ariadne Ontology | DNA replication |
|---|
| Group | DNA replication |
|---|---|
| cell proliferation | |
| heart development | |
| phosphoinositide-mediated signaling | |
| regulation of DNA replication | |
| DNA replication | |
| translesion synthesis | |
| base-excision repair, gap-filling | |
| DNA repair | |
| nucleotide-excision repair, DNA gap filling | |
| mismatch repair | |
| response to lipid | |
| response to cadmium ion | |
| intracellular protein transport | |
| DNA polymerase processivity factor activity | |
| DNA binding | |
| MutLalpha complex binding | |
| dinucleotide insertion or deletion binding | |
| purine-specific mismatch base pair DNA N-glycosylase activity | |
| PCNA complex | |
| cyclin-dependent protein kinase holoenzyme complex | |
| DNA replication factor C complex | |
| replication fork | |
| nucleoplasm | |
| PCNA-p21 complex | |
| nuclear lamina | |
| nuclear replication fork | |
| nucleus |
| MedScan ID | 5111 |
|---|
| Hugo ID | 8729 |
|---|
| Human chromosome position | 20pter-p12 |
|---|
| LocusLink ID | 5111 |
|---|---|
| 18538 | |
| 25737 |
| Alias | MGC8367 |
|---|---|
| proliferating cell nuclear antigen | |
| cyclin | |
| DNA polymerase delta auxiliary protein | |
| RP23-33N15.1 | |
| OTTMUSP00000016567 | |
| PCNAR | |
| Pcna/cyclin | |
| DNA pol delta auxiliary protein | |
| DNA polymerase-delta auxiliary protein | |
| DNApol delta auxiliary protein | |
| OTTHUMP00000030189 | |
| OTTHUMP00000030190 | |
| PCNA | |
| PCNA_HUMAN | |
| proliferating cell nuclear antigen (Spodoptera frugiperda) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 176740 |
|---|
| Mouse chromosome position | 2 75.0 cM |
|---|
| GO ID | 0003677 |
|---|---|
| 0030337 | |
| 0032405 | |
| 0032139 | |
| 0000701 | |
| 0006281 | |
| 0006260 | |
| 0006287 | |
| 0008283 | |
| 0007507 | |
| 0006886 | |
| 0006298 | |
| 0006297 | |
| 0048015 | |
| 0006275 | |
| 0046686 | |
| 0033993 | |
| 0019985 | |
| 0005663 | |
| 0043626 | |
| 0070557 | |
| 0000307 | |
| 0005652 | |
| 0043596 | |
| 0005654 | |
| 0005634 | |
| 0005657 | |
| 0005515 |
| Rat chromosome position | 3q36 |
|---|
| Swiss-Prot Accession | P12004 |
|---|---|
| Q6FHF5 | |
| Q6FI35 | |
| Q7Z6A0 | |
| Q7Z6A1 | |
| Q7Z6A2 | |
| Q7Z6A3 | |
| P17918 | |
| Q542J9 | |
| Q91ZH2 | |
| Q9CZD6 | |
| P04961 | |
| B2R897 | |
| D3DW02 |
| PIR ID | A26631 |
|---|---|
| A27445 | |
| S15703 |
| Unigene ID | Hs.147433 |
|---|---|
| Mm.7141 | |
| Rn.223 |
| KEGG ID | hsa:5111 |
|---|---|
| mmu:18538 | |
| rno:25737 |
| Swiss-Prot ID | PCNA_RAT |
|---|---|
| PCNA_HUMAN | |
| PCNA_MOUSE | |
| D3DW02_HUMAN | |
| Q542J9_MOUSE | |
| B2R897_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00200861 |
|---|---|
| IPI00021700 | |
| IPI00113870 | |
| IPI00385373 | |
| IPI00473170 |
| Homologene ID | 1945 |
|---|
| RGD ID | 3269 |
|---|
| MGI ID | 97503 |
|---|