| URN | urn:agi-llid:5925 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2423 |
| Name | Rb1 |
| Description | retinoblastoma 1 |
| Notes | The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | transcription coactivator activity |
|---|---|
| sequence-specific DNA binding transcription factor activity | |
| phosphoprotein binding | |
| enzyme binding | |
| transcription factor binding | |
| RNA polymerase II activating transcription factor binding | |
| androgen receptor binding | |
| kinase binding | |
| ubiquitin protein ligase binding | |
| DNA binding | |
| core promoter binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| PML body | |
| Rb-E2F complex | |
| SWI-SNF complex | |
| chromatin | |
| spindle | |
| transcription factor complex | |
| nucleus |
| GO Biological Process | enucleate erythrocyte differentiation |
|---|---|
| positive regulation of macrophage differentiation | |
| regulation of lipid kinase activity | |
| skeletal muscle cell differentiation | |
| neuron differentiation | |
| cell morphogenesis involved in neuron differentiation | |
| neuron maturation | |
| neuron projection development | |
| digestive tract development | |
| myoblast differentiation | |
| striated muscle cell differentiation | |
| cell division | |
| cell cycle | |
| maintenance of mitotic sister chromatid cohesion | |
| sister chromatid biorientation | |
| positive regulation of mitotic metaphase-anaphase transition | |
| regulation of cohesin localization to chromatin | |
| regulation of transcription involved in G1-S transition of mitotic cell cycle | |
| cell cycle checkpoint | |
| cell cycle arrest | |
| mitotic cell cycle checkpoint | |
| negative regulation of transcription involved in G1-S transition of mitotic cell cycle | |
| negative regulation of G1-S transition of mitotic cell cycle | |
| G1-S transition of mitotic cell cycle | |
| regulation of cell cycle | |
| mitotic cell cycle | |
| negative regulation of cell cycle | |
| regulation of mitotic cell cycle | |
| Ras protein signal transduction | |
| negative regulation of smoothened signaling pathway | |
| androgen receptor signaling pathway | |
| glial cell apoptotic process | |
| neuron apoptotic process | |
| hepatocyte apoptotic process | |
| negative regulation of cell proliferation | |
| negative regulation of epithelial cell proliferation | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of centromere complex assembly | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter during mitosis | |
| negative regulation of protein kinase activity | |
| regulation of transcription, DNA-templated | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription, DNA-templated | |
| modulation by virus of host morphology or physiology | |
| chromatin modification | |
| chromatin remodeling | |
| protein localization to chromosome, centromeric region |
| Pathway | rRNA Transcription and Processing |
|---|---|
| Cell Cycle | |
| Nuclear Envelope | |
| Cleavage of Lamina in Apoptosis | |
| Androgen Receptor and Cell Cycle | |
| Prostate Cancer Overview | |
| Metastatic Colorectal Cancer Overview | |
| Multiple Myeloma Overview | |
| Proteins Involved in Pathogenesis of Acute Myeloid Leukemia | |
| Proteins Involved in Pathogenesis of Chronic Myeloid Leukemia | |
| Chronic Myeloid Leukemia Overview | |
| B-cell Acute Lymphoblastic Leukemia Overview | |
| T-cell Acute Lymphoblastic Leukemia Overview | |
| Mantle Cell Lymphoma Overview | |
| Deregulation of Cell Cycle and DNA Repair in Mantle Cell Lymphoma | |
| Deregulation of Cell Cycle in Melanoma | |
| Proteins Involved in Pathogenesis of Melanoma | |
| Melanoma Overview | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| Cancer Overview | |
| Primary Glioblastoma | |
| Secondary Glioblastoma | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Classical Subtype of Glioblastoma | |
| Proteins Involved in Pathogenesis of Glioma | |
| Astrocytoma | |
| Medulloblastoma Overview | |
| TP53 Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Pancreatic Neuroendocrine Tumors | |
| TP53 Signaling in Hepatocellular Carcinoma | |
| Proteins Involved in Pathogenesis of Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| FASLG Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| RNA polymerase III transcription pathway |
| Group | Rb |
|---|---|
| Tumor suppressors | |
| enucleate erythrocyte differentiation | |
| positive regulation of macrophage differentiation | |
| regulation of lipid kinase activity | |
| skeletal muscle cell differentiation | |
| neuron differentiation | |
| cell morphogenesis involved in neuron differentiation | |
| neuron maturation | |
| neuron projection development | |
| digestive tract development | |
| myoblast differentiation | |
| striated muscle cell differentiation | |
| cell division | |
| cell cycle | |
| maintenance of mitotic sister chromatid cohesion | |
| sister chromatid biorientation | |
| positive regulation of mitotic metaphase-anaphase transition | |
| regulation of cohesin localization to chromatin | |
| regulation of transcription involved in G1-S transition of mitotic cell cycle | |
| cell cycle checkpoint | |
| cell cycle arrest | |
| mitotic cell cycle checkpoint | |
| negative regulation of transcription involved in G1-S transition of mitotic cell cycle | |
| negative regulation of G1-S transition of mitotic cell cycle | |
| G1-S transition of mitotic cell cycle | |
| regulation of cell cycle | |
| mitotic cell cycle | |
| negative regulation of cell cycle | |
| regulation of mitotic cell cycle | |
| Ras protein signal transduction | |
| negative regulation of smoothened signaling pathway | |
| androgen receptor signaling pathway | |
| glial cell apoptotic process | |
| neuron apoptotic process | |
| hepatocyte apoptotic process | |
| negative regulation of cell proliferation | |
| negative regulation of epithelial cell proliferation | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of centromere complex assembly | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter during mitosis | |
| negative regulation of protein kinase activity | |
| regulation of transcription, DNA-templated | |
| transcription coactivator activity | |
| sequence-specific DNA binding transcription factor activity | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription, DNA-templated | |
| modulation by virus of host morphology or physiology | |
| chromatin modification | |
| chromatin remodeling | |
| protein localization to chromosome, centromeric region | |
| phosphoprotein binding | |
| enzyme binding | |
| transcription factor binding | |
| RNA polymerase II activating transcription factor binding | |
| androgen receptor binding | |
| kinase binding | |
| ubiquitin protein ligase binding | |
| DNA binding | |
| core promoter binding | |
| nucleoplasm | |
| PML body | |
| Rb-E2F complex | |
| SWI-SNF complex | |
| chromatin | |
| spindle | |
| transcription factor complex | |
| nucleus | |
| Genes with Mutations Associated with Multiple Myeloma | |
| Genes with Mutations Associated with B-cell Acute Lymphoblastic Luekemia | |
| Proteins Involved in Pathogenesis of B-cell Acute Lymphoblastic Leukemia | |
| Genes with Mutations Associated with Mantle Cell Lymphoma | |
| Genes with Mutations Associated with Ovarian Cancer | |
| Genes with Mutations Associated with Hepatocellular Carcinoma | |
| Genes with Mutations, Deletions, and Amplifications Associated with Primary Glioblastoma | |
| Genes with Mutations, Deletions, and Amplifications Associated with Secondary Glioblastoma | |
| Genes Hypermethylated in Glioma | |
| Genes with Mutations, Deletions, and Amplifications Associated with Astrocytoma | |
| Genes with Mutations, Deletions, and Amplifications Associated with Glioma | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5925 |
|---|---|
| 19645 | |
| 24708 |
| Cell Localization | Nucleus |
|---|
| GO ID | 0003677 |
|---|---|
| 0001102 | |
| 0050681 | |
| 0001047 | |
| 0019900 | |
| 0051219 | |
| 0003700 | |
| 0003713 | |
| 0008134 | |
| 0031625 | |
| 0000082 | |
| 0007265 | |
| 0030521 | |
| 0007050 | |
| 0000075 | |
| 0048667 | |
| 0006338 | |
| 0048565 | |
| 0043353 | |
| 0034088 | |
| 0000278 | |
| 0007093 | |
| 0019048 | |
| 0045445 | |
| 2000134 | |
| 0050680 | |
| 0006469 | |
| 0043433 | |
| 0045879 | |
| 0007070 | |
| 0071930 | |
| 0045892 | |
| 0051402 | |
| 0042551 | |
| 0031175 | |
| 0045651 | |
| 0045842 | |
| 0045944 | |
| 0045893 | |
| 0071459 | |
| 0090230 | |
| 0071922 | |
| 0043550 | |
| 0007346 | |
| 0000083 | |
| 0031134 | |
| 0035914 | |
| 0051146 | |
| 0006351 | |
| 0016605 | |
| 0035189 | |
| 0016514 | |
| 0000785 | |
| 0005654 | |
| 0005634 | |
| 0005819 | |
| 0019899 | |
| 0007049 | |
| 0051301 | |
| 0016568 | |
| 0034349 | |
| 0097284 | |
| 0045786 | |
| 0008285 | |
| 0000122 | |
| 0030182 | |
| 0051726 | |
| 0006357 | |
| 0006355 | |
| 0005667 |
| Alias | RB |
|---|---|
| pRb | |
| OSRC | |
| pp110 | |
| p105-Rb | |
| RP11-174I10.1 | |
| retinoblastoma-associated protein | |
| retinoblastoma suspectibility protein | |
| Rb-1 | |
| pp105 | |
| Retinoblastoma 1 (including osteosarcoma) | |
| Rb tumour suppressor | |
| retinoblastoma 1 | |
| RBL | |
| RB1 | |
| Retinoblastoma I | |
| rb/P105 | |
| Rb tumor suppressor | |
| RB_HUMAN | |
| retinoblastoma tumor suppressor | |
| retinoblastoma tumour suppressor | |
| tumor suppressor Rb | |
| tumour suppressor Rb | |
| retinoblastoma proteins | |
| retinoblastoma protein | |
| Retinoblastoma associated protein | |
| RB protein | |
| Retinoblastoma tumour suppressor p105 | |
| PP(110) | |
| retinoblastoma susceptibility gene product | |
| RB mRNA | |
| LOC112873 | |
| LOC92728 | |
| mRNA RB | |
| protein RB | |
| OTTHUMP00000018397 | |
| RB gene | |
| gene RB | |
| pRb/P105 | |
| pRb proteins | |
| p-Rb | |
| FLJ16030 | |
| PP-110 | |
| RB I |
| Mouse chromosome position | 14 38.73 cM |
|---|
| OMIM ID | 614041 |
|---|---|
| 109800 | |
| 259500 | |
| 180200 | |
| 182280 |
| Rat chromosome position | 15q12 |
|---|
| Hugo ID | 9884 |
|---|
| Human chromosome position | 13q14.2 |
|---|
| Swiss-Prot Accession | P06400 |
|---|---|
| P13405 | |
| P33568 | |
| Q4VA62 | |
| Q63527 | |
| A8K5E3 | |
| P78499 | |
| Q5VW46 | |
| Q8IZL4 |
| PIR ID | A33718 |
|---|---|
| S35544 | |
| JS0276 |
| Unigene ID | Hs.408528 |
|---|---|
| Mm.273862 | |
| Rn.55115 |
| KEGG ID | hsa:5925 |
|---|---|
| mmu:19645 | |
| rno:24708 |
| Swiss-Prot ID | RB_MOUSE |
|---|---|
| RB_RAT | |
| RB_HUMAN |
| Ensembl ID | ENSG00000139687 |
|---|---|
| ENSP00000267163 | |
| ENST00000267163 | |
| ENSMUSG00000022105 | |
| ENSMUSP00000022701 | |
| ENSMUST00000022701 | |
| ENSRNOG00000016029 | |
| ENSRNOP00000021752 | |
| ENSRNOT00000021752 |
| Homologene ID | 272 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97874 |
|---|
| RGD ID | 3540 |
|---|
| MedScan ID | 5925 |
|---|