Elsevier Inc. pre-tRNA transcript tRNA maturation pathway Sub1 Rb1 TFIIIB Pou2f1 Rb1 ---- SNAPc Sub1 ---- TFIIIC TFIIIB ---- TFIIIC Sub1 ---- TFIIIB Zfp143 --+> SNAPc chromatin modification/remodeling pathway Pou2f1 --+> SNAPc Zfp143 Maf1 ---- RNA polymerase III Maf1 ---| RNA polymerase III Maf1 ---- TFIIIB Maf1 ---| TFIIIB SNAPc ---- TFIIIB RNA polymerase III ---- TFIIIB TFIIIA ---- TFIIIC Rb1 ---| TFIIIB Rb1 ---- TFIIIB Rb1 ---| SNAPc stress stress --+> Maf1 Maf1 mTOR signaling pathway ---| Maf1 SNAPc TFIIIC TFIIIA RNA polymerase III RNA polymerase III ---> pre-tRNA transcript mTOR signaling pathway