| URN | urn:agi-llid:2959 |
|---|---|
| Total Entities | 0 |
| Connectivity | 289 |
| Name | Gtf2b |
| Description | general transcription factor IIB |
| Notes | This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | transcription factor binding |
|---|---|
| TBP-class protein binding | |
| thyroid hormone receptor binding | |
| DNA binding | |
| core promoter binding | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleus |
| GO Biological Process | regulation of transcription, DNA-templated |
|---|---|
| transcription, DNA-templated | |
| DNA-templated transcription, initiation | |
| transcription from RNA polymerase II promoter | |
| transcription elongation from RNA polymerase II promoter | |
| transcription initiation from RNA polymerase II promoter | |
| gene expression | |
| viral process | |
| modulation by virus of host morphology or physiology |
| Pathway | mRNA Transcription and Processing |
|---|---|
| RNA polymerase II transcription initiation pathway | |
| RNA polymerase II transcription pathway |
| Group | Polymerase II transcription |
|---|---|
| regulation of transcription, DNA-templated | |
| transcription, DNA-templated | |
| DNA-templated transcription, initiation | |
| transcription from RNA polymerase II promoter | |
| transcription elongation from RNA polymerase II promoter | |
| transcription initiation from RNA polymerase II promoter | |
| gene expression | |
| viral process | |
| modulation by virus of host morphology or physiology | |
| transcription factor binding | |
| TBP-class protein binding | |
| thyroid hormone receptor binding | |
| DNA binding | |
| core promoter binding | |
| metal ion binding | |
| zinc ion binding | |
| nucleoplasm | |
| nucleus | |
| Secreted proteins |
| LocusLink ID | 2959 |
|---|---|
| 229906 | |
| 81673 |
| Cell Localization | Nucleus |
|---|
| GO ID | 0017025 |
|---|---|
| 0001047 | |
| 0046966 | |
| 0008134 | |
| 0008270 | |
| 0010467 | |
| 0019048 | |
| 0006355 | |
| 0006368 | |
| 0006366 | |
| 0006367 | |
| 0016032 | |
| 0005654 | |
| 0003677 | |
| 0046872 | |
| 0006352 | |
| 0006351 | |
| 0005634 |
| Alias | TF2B |
|---|---|
| TFIIB | |
| RP11-82K18.1 | |
| transcription initiation factor IIB | |
| S300-II | |
| general transcription factor TFIIB | |
| RNA polymerase II transcription factor IIB | |
| RNA polymerase II alpha initiation factor | |
| Transcription initiating factor IIB | |
| transcription factor IIB | |
| TF2B_HUMAN | |
| GTF2B | |
| LOC229906 | |
| MGC:6859 | |
| OTTHUMP00000012347 | |
| OTTHUMP00000012348 | |
| OTTHUMP00000012349 | |
| OTTHUMP00000058838 | |
| general transcription factor IIB |
| Mouse chromosome position | 3 |
|---|
| OMIM ID | 189963 |
|---|
| Rat chromosome position | 2q44 |
|---|
| Hugo ID | 4648 |
|---|
| Human chromosome position | 1p22-p21 |
|---|
| Swiss-Prot Accession | Q00403 |
|---|---|
| P62915 | |
| Q3ULN2 | |
| P62916 | |
| P29053 | |
| A8K1A7 | |
| Q5JS30 |
| PIR ID | S26299 |
|---|---|
| S17654 |
| Unigene ID | Hs.481852 |
|---|---|
| Mm.271756 | |
| Rn.6109 |
| KEGG ID | hsa:2959 |
|---|---|
| mmu:229906 | |
| rno:81673 |
| Swiss-Prot ID | TF2B_RAT |
|---|---|
| TF2B_HUMAN | |
| TF2B_MOUSE |
| Ensembl ID | ENSG00000137947 |
|---|---|
| ENSP00000359531 | |
| ENST00000370500 | |
| ENSMUSG00000028271 | |
| ENSMUSP00000029938 | |
| ENSMUST00000029938 |
| Homologene ID | 1158 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2385191 |
|---|
| RGD ID | 619735 |
|---|
| MedScan ID | 2959 |
|---|
| Primary Cell Localization | Nucleus |
|---|
| IPI ID | IPI00200556 |
|---|---|
| IPI00153874 | |
| IPI00022820 |