| URN | urn:agi-llid:22803 |
|---|---|
| Total Entities | 0 |
| Connectivity | 28 |
| Name | Xrn2 |
| Description | 5'-3' exoribonuclease 2 |
| Notes | This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | hydrolase activity |
|---|---|
| nuclease activity | |
| exonuclease activity | |
| 5'-3' exoribonuclease activity | |
| 5'-3' exonuclease activity | |
| nucleic acid binding | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | nucleolus |
|---|---|
| intracellular | |
| aggresome | |
| nucleus |
| GO Biological Process | spermatogenesis |
|---|---|
| DNA repair | |
| microtubule-based process | |
| cell growth | |
| regulation of transcription, DNA-templated | |
| nucleobase-containing compound metabolic process | |
| transcription, DNA-templated | |
| DNA-templated transcription, termination | |
| RNA catabolic process | |
| DNA catabolic process, exonucleolytic | |
| RNA metabolic process | |
| RNA processing | |
| mRNA processing | |
| RNA phosphodiester bond hydrolysis, exonucleolytic | |
| DNA recombination |
| Pathway | mRNA Degradation |
|---|---|
| RNA polymerase II transcription pathway |
| Group | spermatogenesis |
|---|---|
| DNA repair | |
| microtubule-based process | |
| cell growth | |
| regulation of transcription, DNA-templated | |
| hydrolase activity | |
| nuclease activity | |
| exonuclease activity | |
| 5'-3' exoribonuclease activity | |
| 5'-3' exonuclease activity | |
| nucleobase-containing compound metabolic process | |
| transcription, DNA-templated | |
| DNA-templated transcription, termination | |
| RNA catabolic process | |
| DNA catabolic process, exonucleolytic | |
| RNA metabolic process | |
| RNA processing | |
| mRNA processing | |
| RNA phosphodiester bond hydrolysis, exonucleolytic | |
| DNA recombination | |
| nucleic acid binding | |
| metal ion binding | |
| zinc ion binding | |
| nucleolus | |
| intracellular | |
| aggresome | |
| nucleus |
| LocusLink ID | 22803 |
|---|---|
| 24128 | |
| 362229 |
| Cell Localization | Nucleus |
|---|---|
| Nucleolus |
| GO ID | 0008409 |
|---|---|
| 0004534 | |
| 0004518 | |
| 0003676 | |
| 0008270 | |
| 0000738 | |
| 0006353 | |
| 0006401 | |
| 0016070 | |
| 0006396 | |
| 0016049 | |
| 0006397 | |
| 0006355 | |
| 0007283 | |
| 0016235 | |
| 0005730 | |
| 0005634 | |
| 0004527 | |
| 0016787 | |
| 0046872 | |
| 0006310 | |
| 0006281 | |
| 0090503 | |
| 0007017 | |
| 0006139 | |
| 0006351 | |
| 0005622 |
| Alias | RP11-227D2.1 |
|---|---|
| 5'-3' exoribonuclease 2 | |
| DHP protein | |
| Dhm1-like protein (mouse homolog) | |
| RP23-236O6.1 | |
| protein Dhm1 | |
| Dhm1 | |
| OTTHUMP00000030403 | |
| OTTMUSP00000016705 | |
| XRN2 | |
| FLJ20077 | |
| Dhm1-like | |
| DKFZp434M182 | |
| dJ198K11.2 | |
| dJ198K11 | |
| 5'-3' exoribonuclease II | |
| FLJ10711 |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 608851 |
|---|
| Rat chromosome position | 3q41 |
|---|
| Hugo ID | 12836 |
|---|
| Human chromosome position | 20p11.2-p11.1 |
|---|
| Swiss-Prot Accession | Q9H0D6 |
|---|---|
| Q9DBR1 | |
| D4A914 | |
| Q3TI26 | |
| Q3TKF2 | |
| Q3UZT9 | |
| Q61489 | |
| Q99KS7 | |
| Q3L8N4 | |
| Q6KGZ9 | |
| Q9BQL1 | |
| Q9NTW0 | |
| Q9NXS6 | |
| Q9UL53 |
| PIR ID | I49635 |
|---|
| Unigene ID | Hs.255932 |
|---|---|
| Mm.3065 | |
| Rn.64021 |
| KEGG ID | hsa:22803 |
|---|---|
| mmu:24128 | |
| rno:362229 |
| Swiss-Prot ID | XRN2_MOUSE |
|---|---|
| XRN2_HUMAN |
| EC Number | 3.1.13.- |
|---|
| Ensembl ID | ENSG00000088930 |
|---|---|
| ENSP00000366396 | |
| ENST00000377191 | |
| ENSP00000413548 | |
| ENST00000430571 | |
| ENSMUSG00000027433 | |
| ENSMUSP00000028921 | |
| ENSMUST00000028921 | |
| ENSRNOG00000011785 | |
| ENSRNOP00000016350 | |
| ENSRNOT00000016351 |
| Homologene ID | 6927 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 894687 |
|---|
| RGD ID | 1310218 |
|---|
| MedScan ID | 22803 |
|---|