| URN | urn:agi-llid:1387 |
|---|---|
| Total Entities | 0 |
| Connectivity | 927 |
| Name | Crebbp |
| Description | CREB binding protein |
| Notes | A missense mutation has been identified in codon 1175 of CREBBP in a mild case of Rubinstein-Taybi syndrome. A missense mutation has been identified in codon 1175 of CREBBP in a mild case of Rubinstein-Taybi syndrome. CBP acetylation controls HNF6 protein stability. CBP and p300 function as co-activators of Sox9 for cartilage tissue-specific gene expression and chondrocyte differentiation. CBP enhances tumor necrosis alpha-induced cell death in rheumatoid synoviocytes. CBP has a role in regulating 5-aminolevulinate synthase gene expression via the AP-1 complex in human tumor cells. CBP-induced acetylation of AFX is a novel modification mechanism by which AFX keeps the transcriptional activity mitigating in the nucleus. Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. Estrogen receptor-alpha represses human GnRH receptor gene transcription via an indirect mechanism involving Creb-binding protein. GCMa acetylation is mediated by CBP, which stimulates GCMa transcriptional activity through cyclic AMP/protein kinase A signaling. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE regulate Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. HIV Tat is a general inhibitor of histone acetylation by cellular HATs and for the CREB-binding protein (CBP), it induces a substrate selectivity. IL-6-inducible expression of the hAGT promoter is mediated by physical association of the COOH terminus of STAT3 with p300/CBP, the recruitment of which targets histone acetylation and results in chromatin remodeling. In 92 patients, we were able to identify a total of 36 mutations in CBP. By using multiple ligation-dependent probe amplification, we found not only several deletions but also the first reported intragenic duplication in a patient with RSTS. In conclusion, this research supports FSCN1 as a novel marker of NT2 neuronal differentiation and the possible role of CBP in its regulation. Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. Loss of CREBBP was not statistically significant selection in cancer cells stratified by various criteria for the concordant loss of EP300 and CREBBP. Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma. Mutations and deletions of the CBP gene is associated with lung cancer. Novel heterozygous deletion in CREBBP in Rubinstein-Taybi syndrome patient results in the loss of exon 30. Oct-1 potentiates CREB-dependent cyclin D1 transcriptional activity by a phospho-CREB and CREB binding protein-independent mechanism. PHD finger mutations cause a loss of CBP acetyltransferase activity. Recruitment of Daxx following SUMO modification represents a previously undescribed mechanism in modulating CREB-binding protein (CBP) transcriptional potential. Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene. Smad-binding peptide aptamers can be developed to selectively inhibit TGF-beta-induced gene expression. Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. Suppression of CBP in human mammary epithelial cells results in loss of reconstituted extracellular matrix-mediated growth control and apoptosis and loss of laminin-5 alpha 3-chain expression. The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, there is a crosstalk between lysine acetylation and arginine methylation on chromatin. The KID-interacting domain of human coactivator CREB-binding protein (CBP) is the CBP domain that is targeted by HIV-1 Tat during HIV-1 propagation. The PHD type zinc finger is an integral part of the CBP acetyltransferase domain. The fact that Egr-1 promoter/reporter gene transcription is upregulated by a constitutively active CREB mutant indicates that the CRE couples other signaling cascades via CREB to the Egr-1 gene. The interaction between CtBP and CBP is functionally important and leads to impairment of histone H3 acetylation by CBP at specific lysine residues (Lys9, Lys14, and Lys18) in a dose-dependent and NADH-dependent manner. The interaction of fibroblast growth factor receptor-1: wiwth CREb binding protein allows activation of gene transcription and may play a role in cell differentiation. The site of the KID-interacting (KIX) domain of CBP that recognizes c-Jun and mixed lineage leukemia MLL proteins is identified as the same site that binds HIV-1 Tat protein. We aimed to determine the rate of point mutations and other small molecular lesions in true Rubinstein-Taybi syndrome and possible mild variants, by using genomic DNA sequencing of the CREBBP gene. Activation of CREB-binding protein and inhibition of MAPK has a role in cAMP-dependent protein kinase type I regulation of ethanol-induced cAMP response element-mediated gene expression. Activity of ESE-1 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP. Arginine methylation of CBP is required for IFN-gamma induction of MHC-II. A kinetic analysis shows that CIITA, CARM1, and H3-R17 methylation all precede CBP loading on the MHC-II promoter during IFN-gamma treatment. Arginine methylation represents an important mechanism for modulating CBP co-activator transcriptional activity. Deletion of the CBP bromo- and C/H3 domains eliminates stimulation of nucleosomal histone deacetylase activity in vitro and transcriptional coactivation by EBV Zta in transfected cells. Effect of CREB-binding protein on inhibition of Smad-mediated transcriptional activation by K-bZIP was examined. Glutamine rich and bZIP domains stabilize CREB binding to chromatin. Important functions in coordinated cell cycle progression. In human mammary epithelial cells, CBP/p300 were both modulated by an all-trans-retinoic acid (ATRA) signaling pathway and were required for a normal response to ATRA. Interaction of CREB-binding protein with EWS selectively activates hepatocyte nuclear factor 4-mediated transcription. Is co-expressed with CREB and CBP in extravillous cytotrophoblasts, revealing the in vivo relevance of this transactivation pathway. Overexpression of CBP is detected from the very early stages of laryngeal carcinogenesis, suggesting that CBP may play a role in malignant transformation of precancerous laryngeal lesions. P34SEI-1 strongly suppressed CREB-mediated transcription, and this suppression was overcome by excess amount of CBP. Recruitment to pp90RSK regulates cAMP response element-binding protein activity which is negatively affected by ERK phosphorylation. Results suggest that all-trans-retinoic acid and retinoic acid receptors regulate growth arrest of human mammary epithelial cells and modulate CBP/p300 protein expression. Role in acetylation of beta-catenin. Role in transcriptional control of the inflammatory response. Structurally distinct modes of recognition of the KIX domain of this protein by Jun and CREB. Substrate specificity; structure activity relationship. The conserved bromo-domain of the transcriptional coactivator CBP (CREB binding protein) binds specifically to p53 at the C-terminal acetylated lysine 382. The histone chaperone SET regulates CBP-mediated transcription. |
| Ariadne Ontology | Transcription factors |
|---|
| GO Molecular Function | chromatin binding |
|---|---|
| SMAD binding | |
| p53 binding | |
| transcription factor binding | |
| activating transcription factor binding | |
| RNA polymerase II transcription factor binding | |
| RNA polymerase II activating transcription factor binding | |
| MRF binding | |
| peroxisome proliferator activated receptor binding | |
| DNA binding | |
| core promoter proximal region sequence-specific DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| transferase activity | |
| acetyltransferase activity | |
| histone acetyltransferase activity | |
| transcription cofactor activity | |
| RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription | |
| RNA polymerase II transcription coactivator activity | |
| transcription coactivator activity | |
| sequence-specific DNA binding transcription factor activity | |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | |
| signal transducer activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| nuclear body | |
| transcription factor complex | |
| histone acetyltransferase complex | |
| PML body | |
| nuclear chromatin | |
| condensed chromosome outer kinetochore | |
| protein complex | |
| cytoplasm | |
| nucleus |
| GO Biological Process | cell proliferation |
|---|---|
| virus-host interaction | |
| regulation of S phase | |
| regulation of smoothened signaling pathway | |
| signal transduction | |
| Notch signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| germ-line stem cell maintenance | |
| cellular lipid metabolic process | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| histone acetylation | |
| N-terminal peptidyl-lysine acetylation | |
| cellular response to stress | |
| cellular response to hypoxia | |
| innate immune response | |
| response to hypoxia | |
| embryonic digit morphogenesis | |
| small molecule metabolic process | |
| gene expression | |
| protein complex assembly | |
| homeostatic process |
| Pathway | SRCAP Chromatin Remodeling |
|---|---|
| Histone Acetylation | |
| FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling | |
| T-cell receptor -> CREBBP signaling | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| AREG/CREB/CREBBP Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| ANGPT1/CREB/CREBBP Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| IL16/ATF/CREB/CREBBP Expression Target | |
| CD8/ATF/CREB/CREBBP Expression Targets | |
| CD80/ATF/CREB/CREBBP Expression Targets | |
| CD86/ATF/CREB/CREBBP Expression Targets | |
| CD72/CREB/CREBBP Expression Targets | |
| PDCD1/ATF/CREB/CREBBP Expression Targets | |
| TCR/CREB/CREBBP/ATF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| hypoxia inducible factor pathway | |
| altered hypoxia inducible factor pathway | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway | |
| canonical Wnt signaling pathway | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway | |
| RNA polymerase I transcription pathway |
| Group | Transcription factors |
|---|---|
| cell proliferation | |
| virus-host interaction | |
| regulation of S phase | |
| regulation of smoothened signaling pathway | |
| signal transduction | |
| Notch signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| germ-line stem cell maintenance | |
| cellular lipid metabolic process | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| histone acetylation | |
| N-terminal peptidyl-lysine acetylation | |
| cellular response to stress | |
| cellular response to hypoxia | |
| innate immune response | |
| response to hypoxia | |
| embryonic digit morphogenesis | |
| small molecule metabolic process | |
| gene expression | |
| protein complex assembly | |
| homeostatic process | |
| chromatin binding | |
| SMAD binding | |
| p53 binding | |
| transcription factor binding | |
| activating transcription factor binding | |
| RNA polymerase II transcription factor binding | |
| RNA polymerase II activating transcription factor binding | |
| MRF binding | |
| peroxisome proliferator activated receptor binding | |
| DNA binding | |
| core promoter proximal region sequence-specific DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| transferase activity | |
| acetyltransferase activity | |
| histone acetyltransferase activity | |
| transcription cofactor activity | |
| RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription | |
| RNA polymerase II transcription coactivator activity | |
| transcription coactivator activity | |
| sequence-specific DNA binding transcription factor activity | |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | |
| signal transducer activity | |
| nucleoplasm | |
| nuclear body | |
| transcription factor complex | |
| histone acetyltransferase complex | |
| PML body | |
| nuclear chromatin | |
| condensed chromosome outer kinetochore | |
| protein complex | |
| cytoplasm | |
| nucleus |
| MedScan ID | 1387 |
|---|
| Hugo ID | 2348 |
|---|
| Human chromosome position | 16p13.3 |
|---|
| LocusLink ID | 1387 |
|---|---|
| 12914 | |
| 54244 | |
| 436331 |
| Alias | CBP |
|---|---|
| RSTS | |
| KAT3A | |
| CREB-binding protein | |
| AW558298 | |
| CBP/p300 | |
| p300/CBP | |
| RTS | |
| cyclic AMP-response element-binding protein-binding protein | |
| cAMP response element-binding protein-binding protein | |
| cAMP response element binding protein binding protein | |
| cAMP response element-binding protein binding protein | |
| cyclic AMP responsive element binding protein binding protein | |
| Rubinstein-Taybi syndrome protein | |
| Rubinstein-Taybi syndrome gene | |
| LOC547230 | |
| LOC497663 | |
| LOC436331 | |
| histone acetyltransferase CBP | |
| cyclic AMP-response element-binding protein binding protein | |
| cyclic AMP-response element binding protein binding protein | |
| cyclic AMP responsive element-binding protein binding protein | |
| cAMP responsive element binding protein binding protein | |
| cyclic AMP response element-binding protein-binding protein | |
| cyclic AMP response element-binding protein binding protein | |
| cyclic AMP response element binding protein binding protein | |
| CREBBP | |
| CREB binding protein | |
| CBP_MOUSE | |
| cAMP-response element-binding protein-binding protein | |
| cAMP-response element-binding protein binding protein | |
| cAMP-response element binding protein binding protein | |
| cAMP responsive element-binding protein-binding protein | |
| cAMP responsive element-binding protein binding protein | |
| cyclic AMP responsive element-binding protein-binding protein | |
| Creb binding protein (CBP) | |
| similar to CREB-binding protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600140 |
|---|---|
| 180849 |
| Unigene ID | Hs.459759 |
|---|---|
| Mm.132238 | |
| Mm.392384 | |
| Rn.12815 | |
| Rn.108128 | |
| Mm.387139 | |
| Mm.392739 | |
| Mm.386759 | |
| Mm.393135 |
| KEGG ID | hsa:1387 |
|---|---|
| mmu:12914 | |
| rno:54244 |
| Swiss-Prot Accession | Q4LE28 |
|---|---|
| Q92793 | |
| F8VPR5 | |
| Q6GQV9 | |
| P45481 | |
| F1M9G7 | |
| Q6JHU9 | |
| D3DUC9 | |
| O00147 | |
| Q16376 | |
| O60424 | |
| Q4G0V0 | |
| Q712H6 | |
| Q75MY6 | |
| Q3V351 | |
| Q8QZV8 | |
| Q812C1 | |
| Q812C2 | |
| Q91XT1 |
| EC Number | 2.3.1.48 |
|---|
| GO ID | 0043426 |
|---|---|
| 0001102 | |
| 0001078 | |
| 0001105 | |
| 0001085 | |
| 0001191 | |
| 0046332 | |
| 0016407 | |
| 0003682 | |
| 0000987 | |
| 0004402 | |
| 0002039 | |
| 0042975 | |
| 0003700 | |
| 0004871 | |
| 0003713 | |
| 0008134 | |
| 0008270 | |
| 0018076 | |
| 0007219 | |
| 0008283 | |
| 0044255 | |
| 0071456 | |
| 0033554 | |
| 0042733 | |
| 0010467 | |
| 0030718 | |
| 0016573 | |
| 0042592 | |
| 0045087 | |
| 0000122 | |
| 0045893 | |
| 0006461 | |
| 0033261 | |
| 0008589 | |
| 0061418 | |
| 0006355 | |
| 0001666 | |
| 0007165 | |
| 0044281 | |
| 0006367 | |
| 0019048 | |
| 0000940 | |
| 0005737 | |
| 0000123 | |
| 0016604 | |
| 0000790 | |
| 0005654 | |
| 0005634 | |
| 0005667 | |
| 0003677 | |
| 0033613 | |
| 0046872 | |
| 0003712 | |
| 0016740 | |
| 0051091 | |
| 0045944 | |
| 0006351 | |
| 0016605 | |
| 0043234 | |
| 0051577 | |
| 0044419 | |
| 0045941 | |
| 0045449 | |
| 0016563 | |
| 0006350 | |
| 0005515 |
| PIR ID | S39162 |
|---|
| Swiss-Prot ID | CBP_HUMAN |
|---|---|
| Q4LE28_HUMAN | |
| D3DUC9_HUMAN | |
| Q6GQV9_MOUSE | |
| Q6JHU9_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00023339 |
|---|---|
| IPI00619932 | |
| IPI00463549 | |
| IPI00155855 | |
| IPI00875480 | |
| IPI00652158 | |
| IPI00751842 | |
| IPI00421436 | |
| IPI00781902 |
| Mouse chromosome position | 16 A1 |
|---|
| Rat chromosome position | 10q12 |
|---|
| Homologene ID | 68393 |
|---|
| MGI ID | 1098280 |
|---|
| RGD ID | 2401 |
|---|
| Primary Cell Localization | Nucleus |
|---|