| URN | urn:agi-llid:51547 |
|---|---|
| Total Entities | 0 |
| Connectivity | 69 |
| Name | Sirt7 |
| Description | sirtuin 7 |
| Notes | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Chromatin remodeling |
|---|
| GO Molecular Function | chromatin binding |
|---|---|
| NAD+ binding | |
| metal ion binding | |
| hydrolase activity | |
| NAD-dependent histone deacetylase activity (H3-K18 specific) |
| GO Cellular Component | nucleolus |
|---|---|
| nucleolus organizer region | |
| cytoplasm | |
| nucleus |
| GO Biological Process | positive regulation of transcription on exit from mitosis |
|---|---|
| negative regulation of transcription from RNA polymerase II promoter | |
| rRNA transcription | |
| histone H3 deacetylation |
| Pathway | RNA polymerase I transcription pathway |
|---|
| Group | Chromatin remodeling |
|---|---|
| positive regulation of transcription on exit from mitosis | |
| negative regulation of transcription from RNA polymerase II promoter | |
| rRNA transcription | |
| histone H3 deacetylation | |
| chromatin binding | |
| NAD+ binding | |
| metal ion binding | |
| hydrolase activity | |
| NAD-dependent histone deacetylase activity (H3-K18 specific) | |
| nucleolus | |
| nucleolus organizer region | |
| cytoplasm | |
| nucleus |
| MedScan ID | 51547 |
|---|---|
| 303745 |
| Hugo ID | 14935 |
|---|
| Human chromosome position | 17q25 |
|---|
| LocusLink ID | 51547 |
|---|---|
| 209011 | |
| 303745 |
| Alias | SIR2L7 |
|---|---|
| NAD-dependent protein deacetylase sirtuin-7 | |
| sirtuin type 7 | |
| SIR2-like protein 7 | |
| sir2-related protein type 7 | |
| regulatory protein SIR2 homolog 7 | |
| NAD-dependent deacetylase sirtuin-7 | |
| silent mating type information regulation 2, S.cerevisiae, homolog 7 | |
| RP23-84C12.8 | |
| Sirt7 | |
| sirtuin silent mating type information regulation 2 homolog VII | |
| sirtuin silent mating type information regulation 2 homolog 7 | |
| sirtuin homolog VII | |
| sirtuin homolog 7 | |
| sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) | |
| sirtuin 7 (silent mating type information regulation 2, homolog) 7 | |
| sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) | |
| sirtuin type VII | |
| MGC31235 | |
| sir2-related protein type VII | |
| MGC126842 | |
| MGC37560 | |
| silent mating type information regulation 2, S.cerevisiae, homolog VII | |
| MGC126840 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606212 |
|---|
| Unigene ID | Hs.514636 |
|---|---|
| Mm.292957 | |
| Rn.23064 |
| KEGG ID | hsa:51547 |
|---|---|
| mmu:209011 | |
| rno:303745 |
| Swiss-Prot Accession | Q9NRC8 |
|---|---|
| Q8BKJ9 | |
| B2RZ55 | |
| A8K2K0 | |
| B3KSU8 | |
| Q3MIK4 | |
| Q9NSZ6 | |
| Q9NUS6 | |
| F1LQY4 | |
| A2ABY7 | |
| Q6X7B7 | |
| Q8QZZ5 |
| EC Number | 3.5.1.- |
|---|
| GO ID | 0070403 |
|---|---|
| 0097372 | |
| 0003682 | |
| 0046872 | |
| 0070932 | |
| 0000122 | |
| 0007072 | |
| 0009303 | |
| 0005737 | |
| 0005730 | |
| 0005731 | |
| 0016787 | |
| 0005634 |
| PIR ID | T46324 |
|---|
| Swiss-Prot ID | SIR7_HUMAN |
|---|---|
| SIR7_RAT | |
| SIR7_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| nucleolus |
| IPI ID | IPI00334648 |
|---|---|
| IPI00383601 | |
| IPI00768355 | |
| IPI00380790 |
| Mouse chromosome position | 11 |
|---|
| Rat chromosome position | 10q32.3 |
|---|
| Homologene ID | 56152 |
|---|
| MGI ID | 2385849 |
|---|
| RGD ID | 1305876 |
|---|
| Primary Cell Localization | Nucleus |
|---|