| URN | urn:agi-llid:6827 |
|---|---|
| Total Entities | 0 |
| Connectivity | 26 |
| Name | Supt4h1 |
| Description | suppressor of Ty 4 homolog 1 (S. cerevisiae) |
| Notes | This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] |
| GO Molecular Function | sequence-specific DNA binding transcription factor activity |
|---|---|
| protein heterodimerization activity | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| DSIF complex | |
| nucleus |
| GO Biological Process | positive regulation of DNA-templated transcription, elongation |
|---|---|
| positive regulation of viral transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of DNA-templated transcription, elongation | |
| negative regulation of transcription elongation from RNA polymerase II promoter | |
| regulation of transcription, DNA-templated | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription, DNA-templated | |
| transcription from RNA polymerase II promoter | |
| transcription elongation from RNA polymerase II promoter | |
| gene expression | |
| viral process | |
| chromatin remodeling |
| Pathway | RNA polymerase I transcription pathway |
|---|---|
| RNA polymerase I transcription pathway |
| Group | Polymerase II transcription |
|---|---|
| positive regulation of DNA-templated transcription, elongation | |
| positive regulation of viral transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of DNA-templated transcription, elongation | |
| negative regulation of transcription elongation from RNA polymerase II promoter | |
| regulation of transcription, DNA-templated | |
| sequence-specific DNA binding transcription factor activity | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription, DNA-templated | |
| transcription from RNA polymerase II promoter | |
| transcription elongation from RNA polymerase II promoter | |
| gene expression | |
| viral process | |
| chromatin remodeling | |
| protein heterodimerization activity | |
| metal ion binding | |
| zinc ion binding | |
| nucleoplasm | |
| DSIF complex | |
| nucleus |
| LocusLink ID | 6827 |
|---|---|
| 20922 | |
| 287608 |
| Cell Localization | Nucleus |
|---|
| GO ID | 0046982 |
|---|---|
| 0003700 | |
| 0008270 | |
| 0006338 | |
| 0010467 | |
| 0032785 | |
| 0034244 | |
| 0000122 | |
| 0032786 | |
| 0045944 | |
| 0050434 | |
| 0006357 | |
| 0006355 | |
| 0006368 | |
| 0006366 | |
| 0016032 | |
| 0032044 | |
| 0005654 | |
| 0005634 | |
| 0046872 | |
| 0006351 |
| Alias | SPT4 |
|---|---|
| SPT4H | |
| SUPT4H | |
| transcription elongation factor SPT4 | |
| DSIF p14 | |
| small hSpt4 subunit | |
| DRB sensitivity-inducing factor 14 kDa subunit | |
| Supt4h1 | |
| AL022777 | |
| Supt4h1a | |
| RP23-449P23.2 | |
| transcription elongation factor SPT4-A | |
| DSIF small subunit 1 | |
| suppressor of Ty 4 homolog 1 | |
| transcription elongation factor SPT4 1 | |
| DRB sensitivity-inducing factor small subunit 1 | |
| Supt4h2 | |
| suppressor of Ty 4 homolog 2 | |
| suppressor of Ty 4A | |
| suppressor of Ty 4 homolog 1 (S. cerevisiae) | |
| suppressor of Ty 4 homolog I | |
| SUPT4H I | |
| Transcription initiation protein SPT4 homolog | |
| Supt4a | |
| Transcription initiating protein SPT4 homolog | |
| DRB sensitivity-inducing factor small subunit | |
| suppressor of Ty 4 homolog | |
| MGC188814 | |
| DSIF small subunit | |
| hSPT4 | |
| suppressor of Ty (S.cerevisiae) 4 homolog | |
| suppressor of Ty (S.cerevisiae) 4 homolog 1 | |
| suppressor of Ty (S.cerevisiae) 4 homolog I | |
| OTTMUSP00000001305 |
| Mouse chromosome position | 11 52.2 cM |
|---|---|
| 11 49.0 cM |
| OMIM ID | 603555 |
|---|
| Rat chromosome position | 10q26 |
|---|
| Hugo ID | 11467 |
|---|
| Human chromosome position | 17q21-q23 |
|---|
| Swiss-Prot Accession | P63272 |
|---|---|
| P63271 | |
| B5DEM7 | |
| B2R4X8 | |
| D3DTZ4 | |
| Q16550 | |
| Q62387 | |
| Q6ZP89 | |
| B2KGH6 | |
| Q3TIA2 | |
| Q5NCP8 | |
| Q5NCP9 | |
| Q5NCQ0 |
| Unigene ID | Hs.439481 |
|---|---|
| Hs.718477 | |
| Mm.622 | |
| Rn.7906 |
| KEGG ID | hsa:6827 |
|---|---|
| mmu:20922 | |
| rno:287608 |
| Swiss-Prot ID | SPT4H_HUMAN |
|---|---|
| SPT4A_MOUSE | |
| SPT41_MOUSE |
| Ensembl ID | ENSG00000213246 |
|---|---|
| ENSP00000225504 | |
| ENST00000225504 | |
| ENSMUSG00000020485 | |
| ENSMUSP00000091487 | |
| ENSMUST00000093955 | |
| ENSRNOG00000007845 | |
| ENSRNOP00000010448 | |
| ENSRNOT00000010448 |
| Homologene ID | 68303 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 107416 |
|---|
| RGD ID | 1306372 |
|---|
| MedScan ID | 6827 |
|---|
| Primary Cell Localization | Nucleus |
|---|
| IPI ID | IPI00124000 |
|---|---|
| IPI00002895 |