Protein Ptrf

URN	urn:agi-llid:22939
Total Entities	0
Connectivity	132
Name	Ptrf
Description	polymerase I and transcript release factor
Notes	This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

GO Molecular Function	RNA binding
	rRNA binding
	rRNA primary transcript binding

GO Cellular Component	membrane
	caveola
	nucleoplasm
	plasma membrane
	cytoplasm
	cytosol
	endoplasmic reticulum
	mitochondrion
	intracellular membrane-bounded organelle
	nucleus

GO Biological Process	regulation of transcription, DNA-templated
	transcription, DNA-templated
	DNA-templated transcription, termination
	transcription from RNA polymerase I promoter
	transcription initiation from RNA polymerase I promoter
	termination of RNA polymerase I transcription
	gene expression

Pathway	Transcytosis
	RNA polymerase I transcription pathway
	RNA polymerase I transcription pathway

Group	Polymerase I transcription
	regulation of transcription, DNA-templated
	transcription, DNA-templated
	DNA-templated transcription, termination
	transcription from RNA polymerase I promoter
	transcription initiation from RNA polymerase I promoter
	termination of RNA polymerase I transcription
	gene expression
	RNA binding
	rRNA binding
	rRNA primary transcript binding
	membrane
	caveola
	nucleoplasm
	plasma membrane
	cytoplasm
	cytosol
	endoplasmic reticulum
	mitochondrion
	intracellular membrane-bounded organelle
	nucleus

Alias	CGL4
	CAVIN
	CAVIN1
	FKSG13
	cavin-1
	polymerase I and transcript release factor
	TTF-I interacting peptide 12
	RNA polymerase I and transcript release factor
	Cav-p60
	AW546441
	2310075E07Rik
	RP23-279L23.6
	RIKEN cDNA 2310075E07 gene
	polymerase I and transcript release factor/cavin-1
	PTRF
	PTRF/cavin-1
	PTRF-CAVIN
	TTF-I interactive peptide XII
	Polymerase I and transcript release factor/Cavin
	TTF-I interactive peptide 12
	2310075E07
	MGC118550
	FLJ90031
	OTTMUSP00000002049

Mouse chromosome position	11 63.95 cM
	11 60.5 cM

OMIM ID	603198
	613327

Rat chromosome position	10q32.1

Hugo ID	9688

Human chromosome position	17q21.2

Swiss-Prot ID	PTRF_HUMAN
	PTRF_MOUSE

Homologene ID	7499

MGI ID	1277968

RGD ID	1307685

MedScan ID	22939

Primary Cell Localization	Nucleus