| URN | urn:agi-llid:7270 |
|---|---|
| Total Entities | 0 |
| Connectivity | 39 |
| Name | Ttf1 |
| Description | transcription termination factor, RNA polymerase I |
| Notes | This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011] |
| GO Molecular Function | chromatin binding |
|---|---|
| DNA binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| nucleus |
| GO Biological Process | negative regulation of DNA replication |
|---|---|
| regulation of transcription, DNA-templated | |
| transcription, DNA-templated | |
| DNA-templated transcription, termination | |
| transcription from RNA polymerase I promoter | |
| transcription initiation from RNA polymerase I promoter | |
| termination of RNA polymerase I transcription | |
| gene expression | |
| chromatin remodeling |
| Pathway | rRNA Transcription and Processing |
|---|---|
| RNA polymerase I transcription pathway | |
| RNA polymerase I transcription pathway |
| Group | Polymerase I transcription |
|---|---|
| negative regulation of DNA replication | |
| regulation of transcription, DNA-templated | |
| transcription, DNA-templated | |
| DNA-templated transcription, termination | |
| transcription from RNA polymerase I promoter | |
| transcription initiation from RNA polymerase I promoter | |
| termination of RNA polymerase I transcription | |
| gene expression | |
| chromatin remodeling | |
| chromatin binding | |
| DNA binding | |
| nucleoplasm | |
| nucleolus | |
| nucleus |
| LocusLink ID | 7270 |
|---|---|
| 22130 | |
| 499766 |
| Cell Localization | Nucleus |
|---|---|
| Nucleolus |
| GO ID | 0003677 |
|---|---|
| 0003682 | |
| 0006353 | |
| 0006338 | |
| 0010467 | |
| 0008156 | |
| 0006355 | |
| 0006363 | |
| 0006360 | |
| 0006361 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0006351 |
| Alias | TTF-1 |
|---|---|
| TTF-I | |
| transcription termination factor 1 | |
| AV245725 | |
| RP23-426D2.3 | |
| transcription termination factor I | |
| RNA polymerase I termination factor | |
| RGD1565673 | |
| transcription termination factor, RNA polymerase I | |
| transcription terminating factor I | |
| transcription terminating factor, RNA polymerase I | |
| transcription terminating factor, RNA polymerase 1 | |
| OTTMUSP00000012613 | |
| mTFF-I | |
| transcription terminating factor 1 |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 600777 |
|---|
| Rat chromosome position | 3p12 |
|---|
| Hugo ID | 12397 |
|---|
| Human chromosome position | 9q34.13 |
|---|
| Swiss-Prot Accession | Q15361 |
|---|---|
| Q3TQG6 | |
| Q62187 | |
| A1L160 | |
| Q4VXF3 | |
| Q58EY2 | |
| Q6P5T5 | |
| Q9JKK5 | |
| A2AR36 | |
| D4A1Z7 |
| PIR ID | I38182 |
|---|---|
| S54776 |
| Unigene ID | Hs.54780 |
|---|---|
| Hs.732733 | |
| Mm.252195 |
| KEGG ID | hsa:7270 |
|---|---|
| mmu:22130 | |
| rno:499766 |
| Swiss-Prot ID | TTF1_HUMAN |
|---|---|
| TTF1_MOUSE |
| Ensembl ID | ENSG00000125482 |
|---|---|
| ENSP00000333920 | |
| ENST00000334270 | |
| ENSMUSG00000026803 | |
| ENSMUSP00000097809 | |
| ENSMUST00000100237 |
| Homologene ID | 49133 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 105044 |
|---|
| RGD ID | 1565673 |
|---|
| MedScan ID | 7270 |
|---|
| Primary Cell Localization | Nucleus |
|---|
| IPI ID | IPI00466645 |
|---|---|
| IPI00385712 |