Protein Sirt7

URN	urn:agi-llid:51547
Total Entities	0
Connectivity	145
Name	Sirt7
Description	sirtuin 7
Notes	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

GO Molecular Function	NAD-dependent histone deacetylase activity (H3-K18 specific)
	hydrolase activity
	chromatin binding
	NAD+ binding
	metal ion binding

GO Biological Process	histone H3 deacetylation
	histone H4 deacetylation
	positive regulation of transcription on exit from mitosis
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-templated
	transcription, DNA-templated
	rRNA transcription
	chromatin modification

Pathway	RNA polymerase I transcription pathway
	RNA polymerase I transcription pathway

Group	Chromatin remodeling
	histone H3 deacetylation
	histone H4 deacetylation
	NAD-dependent histone deacetylase activity (H3-K18 specific)
	positive regulation of transcription on exit from mitosis
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-templated
	hydrolase activity
	transcription, DNA-templated
	rRNA transcription
	chromatin modification
	chromatin binding
	NAD+ binding
	metal ion binding
	nucleolus
	nucleolus organizer region
	cytoplasm
	nucleus

Alias	SIR2L7
	NAD-dependent protein deacetylase sirtuin-7
	sirtuin type 7
	SIR2-like protein 7
	sir2-related protein type 7
	regulatory protein SIR2 homolog 7
	NAD-dependent deacetylase sirtuin-7
	silent mating type information regulation 2, S.cerevisiae, homolog 7
	RP23-84C12.8
	sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
	sirtuin type VII
	sirtuin silent mating type information regulation 2 homolog VII
	sirtuin silent mating type information regulation 2 homolog 7
	sirtuin homolog VII
	sirtuin homolog 7
	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)
	sirtuin 7 (silent mating type information regulation 2, homolog) 7
	Sirt7
	MGC126842
	MGC37560
	MGC126840
	silent mating type information regulation 2, S.cerevisiae, homolog VII
	sir2-related protein type VII
	MGC31235

Mouse chromosome position	11

OMIM ID	606212

Rat chromosome position	10q32.3

Hugo ID	14935

Human chromosome position	17q25

PIR ID	T46324

EC Number	3.5.1.-

Homologene ID	56152

MGI ID	2385849

RGD ID	1305876

MedScan ID	51547
	303745

Primary Cell Localization	Nucleus