| URN | urn:agi-llid:309757 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1 |
| Name | Sirt1 |
| Description | sirtuin 1 |
| GO Molecular Function | histone deacetylase activity |
|---|---|
| NAD-dependent histone deacetylase activity | |
| NAD-dependent histone deacetylase activity (H3-K9 specific) | |
| transcription corepressor activity | |
| deacetylase activity | |
| protein deacetylase activity | |
| NAD-dependent protein deacetylase activity | |
| protein domain specific binding | |
| protein C-terminus binding | |
| histone binding | |
| enzyme binding | |
| p53 binding | |
| bHLH transcription factor binding | |
| mitogen-activated protein kinase binding | |
| HLH domain binding | |
| NAD+ binding |
| GO Cellular Component | nuclear inner membrane |
|---|---|
| chromatin silencing complex | |
| nucleoplasm | |
| nuclear envelope | |
| nucleolus | |
| PML body | |
| ESC-E(Z) complex | |
| nuclear chromatin | |
| nuclear heterochromatin | |
| nuclear euchromatin | |
| chromatin | |
| rDNA heterochromatin | |
| cytoplasm | |
| nucleus |
| GO Biological Process | spermatogenesis |
|---|---|
| ovulation from ovarian follicle | |
| positive regulation of adaptive immune response | |
| positive regulation of DNA repair | |
| DNA synthesis involved in DNA repair | |
| single strand break repair | |
| pyrimidine dimer repair by nucleotide-excision repair | |
| negative regulation of prostaglandin biosynthetic process | |
| regulation of bile acid biosynthetic process | |
| histone deacetylation | |
| histone H3 deacetylation | |
| positive regulation of macroautophagy | |
| regulation of glucose metabolic process | |
| triglyceride mobilization | |
| angiogenesis | |
| negative regulation of fat cell differentiation | |
| white fat cell differentiation | |
| positive regulation of cellular senescence | |
| negative regulation of cellular senescence | |
| regulation of mitotic cell cycle | |
| negative regulation of I-kappaB kinase-NF-kappaB signaling | |
| intrinsic apoptotic signaling pathway in response to DNA damage | |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress | |
| negative regulation of protein kinase B signaling | |
| negative regulation of TOR signaling | |
| negative regulation of DNA damage response, signal transduction by p53 class mediator | |
| positive regulation of insulin receptor signaling pathway | |
| regulation of peroxisome proliferator activated receptor signaling pathway | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| negative regulation of androgen receptor signaling pathway | |
| cellular response to starvation | |
| negative regulation of cell growth | |
| establishment of chromatin silencing | |
| maintenance of chromatin silencing | |
| chromatin silencing at rDNA | |
| positive regulation of chromatin silencing | |
| cellular triglyceride homeostasis | |
| cellular glucose homeostasis | |
| positive regulation of apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| negative regulation of apoptotic process | |
| regulation of smooth muscle cell apoptotic process | |
| positive regulation of macrophage apoptotic process | |
| positive regulation of cell proliferation | |
| regulation of cell proliferation | |
| regulation of protein import into nucleus, translocation | |
| positive regulation of cholesterol efflux | |
| response to hydrogen peroxide | |
| cellular response to hydrogen peroxide | |
| negative regulation of cellular response to testosterone stimulus | |
| response to insulin | |
| cellular response to tumor necrosis factor | |
| cellular response to hypoxia | |
| response to oxidative stress | |
| cellular response to DNA damage stimulus | |
| response to nutrient levels | |
| cellular response to ionizing radiation | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of cAMP-dependent protein kinase activity | |
| positive regulation of MHC class II biosynthetic process | |
| regulation of endodeoxyribonuclease activity | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of phosphorylation | |
| negative regulation of cAMP-dependent protein kinase activity | |
| negative regulation of peptidyl-lysine acetylation | |
| regulation of RNA biosynthetic process | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of NF-kappaB transcription factor activity | |
| protein destabilization | |
| negative regulation of helicase activity | |
| protein deacetylation | |
| peptidyl-lysine deacetylation | |
| peptidyl-lysine acetylation | |
| protein ubiquitination | |
| proteasome-mediated ubiquitin-dependent protein catabolic process | |
| fatty acid homeostasis | |
| cholesterol homeostasis |
| Pathway | RNA polymerase I transcription pathway |
|---|---|
| RNA polymerase I transcription pathway |
| Group | Transcription factors |
|---|---|
| spermatogenesis | |
| ovulation from ovarian follicle | |
| positive regulation of adaptive immune response | |
| positive regulation of DNA repair | |
| DNA synthesis involved in DNA repair | |
| single strand break repair | |
| pyrimidine dimer repair by nucleotide-excision repair | |
| negative regulation of prostaglandin biosynthetic process | |
| regulation of bile acid biosynthetic process | |
| histone deacetylation | |
| histone H3 deacetylation | |
| histone deacetylase activity | |
| NAD-dependent histone deacetylase activity | |
| NAD-dependent histone deacetylase activity (H3-K9 specific) | |
| positive regulation of macroautophagy | |
| regulation of glucose metabolic process | |
| triglyceride mobilization | |
| angiogenesis | |
| negative regulation of fat cell differentiation | |
| white fat cell differentiation | |
| positive regulation of cellular senescence | |
| negative regulation of cellular senescence | |
| regulation of mitotic cell cycle | |
| negative regulation of I-kappaB kinase-NF-kappaB signaling | |
| intrinsic apoptotic signaling pathway in response to DNA damage | |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress | |
| negative regulation of protein kinase B signaling | |
| negative regulation of TOR signaling | |
| negative regulation of DNA damage response, signal transduction by p53 class mediator | |
| positive regulation of insulin receptor signaling pathway | |
| regulation of peroxisome proliferator activated receptor signaling pathway | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| negative regulation of androgen receptor signaling pathway | |
| cellular response to starvation | |
| negative regulation of cell growth | |
| establishment of chromatin silencing | |
| maintenance of chromatin silencing | |
| chromatin silencing at rDNA | |
| positive regulation of chromatin silencing | |
| cellular triglyceride homeostasis | |
| cellular glucose homeostasis | |
| positive regulation of apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| negative regulation of apoptotic process | |
| regulation of smooth muscle cell apoptotic process | |
| positive regulation of macrophage apoptotic process | |
| positive regulation of cell proliferation | |
| regulation of cell proliferation | |
| regulation of protein import into nucleus, translocation | |
| positive regulation of cholesterol efflux | |
| response to hydrogen peroxide | |
| cellular response to hydrogen peroxide | |
| negative regulation of cellular response to testosterone stimulus | |
| response to insulin | |
| cellular response to tumor necrosis factor | |
| cellular response to hypoxia | |
| response to oxidative stress | |
| cellular response to DNA damage stimulus | |
| response to nutrient levels | |
| cellular response to ionizing radiation | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of cAMP-dependent protein kinase activity | |
| positive regulation of MHC class II biosynthetic process | |
| regulation of endodeoxyribonuclease activity | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of phosphorylation | |
| negative regulation of cAMP-dependent protein kinase activity | |
| negative regulation of peptidyl-lysine acetylation | |
| regulation of RNA biosynthetic process | |
| transcription corepressor activity | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of NF-kappaB transcription factor activity | |
| protein destabilization | |
| negative regulation of helicase activity | |
| deacetylase activity | |
| protein deacetylase activity | |
| NAD-dependent protein deacetylase activity | |
| protein deacetylation | |
| peptidyl-lysine deacetylation | |
| peptidyl-lysine acetylation | |
| protein ubiquitination | |
| proteasome-mediated ubiquitin-dependent protein catabolic process | |
| fatty acid homeostasis | |
| cholesterol homeostasis | |
| protein domain specific binding | |
| protein C-terminus binding | |
| histone binding | |
| enzyme binding | |
| p53 binding | |
| bHLH transcription factor binding | |
| mitogen-activated protein kinase binding | |
| HLH domain binding | |
| NAD+ binding | |
| nuclear inner membrane | |
| chromatin silencing complex | |
| nucleoplasm | |
| nuclear envelope | |
| nucleolus | |
| PML body | |
| ESC-E(Z) complex | |
| nuclear chromatin | |
| nuclear heterochromatin | |
| nuclear euchromatin | |
| chromatin | |
| rDNA heterochromatin | |
| cytoplasm | |
| nucleus |
| LocusLink ID | 309757 |
|---|
| Cell Localization | Nucleus |
|---|
| GO ID | 0043398 |
|---|---|
| 0070403 | |
| 0017136 | |
| 0046969 | |
| 0034979 | |
| 0043425 | |
| 0019213 | |
| 0019899 | |
| 0042393 | |
| 0004407 | |
| 0051019 | |
| 0002039 | |
| 0008022 | |
| 0033558 | |
| 0019904 | |
| 0003714 | |
| 0000731 | |
| 0001525 | |
| 0001678 | |
| 0006974 | |
| 0070301 | |
| 0071456 | |
| 0071479 | |
| 0009267 | |
| 0071356 | |
| 0035356 | |
| 0042632 | |
| 0000183 | |
| 0006343 | |
| 0055089 | |
| 0070932 | |
| 0016575 | |
| 0008630 | |
| 0042771 | |
| 0006344 | |
| 0043518 | |
| 0043124 | |
| 0032088 | |
| 0032007 | |
| 0060766 | |
| 0043066 | |
| 2000480 | |
| 0030308 | |
| 2000655 | |
| 2000773 | |
| 0045599 | |
| 0051097 | |
| 1902166 | |
| 1902176 | |
| 2000757 | |
| 0042326 | |
| 0031393 | |
| 0051898 | |
| 0043433 | |
| 0000122 | |
| 0045892 | |
| 0030512 | |
| 0001542 | |
| 0018394 | |
| 0034983 | |
| 0045739 | |
| 0045348 | |
| 0002821 | |
| 0043065 | |
| 2000481 | |
| 0008284 | |
| 2000774 | |
| 0010875 | |
| 0031937 | |
| 0043280 | |
| 0046628 | |
| 0016239 | |
| 2000111 | |
| 0001934 | |
| 0045944 | |
| 0043161 | |
| 0006476 | |
| 0031648 | |
| 0016567 | |
| 0000720 | |
| 2001141 | |
| 0070857 | |
| 0042127 | |
| 0032071 | |
| 0010906 | |
| 0007346 | |
| 0035358 | |
| 0033158 | |
| 0034391 | |
| 0042542 | |
| 0032868 | |
| 0031667 | |
| 0006979 | |
| 0000012 | |
| 0007283 | |
| 0006642 | |
| 0050872 | |
| 0035098 | |
| 0016605 | |
| 0000785 | |
| 0005677 | |
| 0005737 | |
| 0000790 | |
| 0005635 | |
| 0005719 | |
| 0005720 | |
| 0005637 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0033553 |
| Alias | Sir2 |
|---|---|
| NAD-dependent deacetylase sirtuin-1 | |
| Sir2alpha | |
| sirtuin 1 ((silent mating type information regulation 2, homolog) 1 |
| Rat chromosome position | 20p11 |
|---|
| GenBank ID | NC_005119 |
|---|---|
| XM_006256146 | |
| XP_006256208 | |
| AC_000088 | |
| XM_006223877 | |
| XP_006223939 | |
| AABR06099923 | |
| AAHX01100800 | |
| CH473988 | |
| EDL97350 | |
| EDL97351 | |
| XM_003751934 | |
| XP_003751982 | |
| XM_003753475 | |
| XP_003753523 |
| KEGG ID | rno:309757 |
|---|
| Organism | Rattus norvegicus |
|---|
| RGD ID | 1308542 |
|---|
| MedScan ID | 309757 |
|---|