Protein Ubtf

URN	urn:agi-llid:7343
Total Entities	0
Connectivity	75
Name	Ubtf
Description	upstream binding transcription factor, RNA polymerase I
Notes	This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

GO Molecular Function	DNA binding

GO Biological Process	embryo implantation
	blastocyst growth
	chromatin silencing at rDNA
	positive regulation of transcription from RNA polymerase I promoter
	regulation of transcription, DNA-templated
	regulation of transcription from RNA polymerase I promoter
	transcription, DNA-templated
	transcription from RNA polymerase I promoter
	transcription initiation from RNA polymerase I promoter
	termination of RNA polymerase I transcription
	transcription elongation from RNA polymerase I promoter
	gene expression

Pathway	rRNA Transcription and Processing
	RNA polymerase I transcription pathway
	RNA polymerase I transcription pathway

Group	UBTF
	Polymerase I transcription
	embryo implantation
	blastocyst growth
	chromatin silencing at rDNA
	positive regulation of transcription from RNA polymerase I promoter
	regulation of transcription, DNA-templated
	regulation of transcription from RNA polymerase I promoter
	transcription, DNA-templated
	transcription from RNA polymerase I promoter
	transcription initiation from RNA polymerase I promoter
	termination of RNA polymerase I transcription
	transcription elongation from RNA polymerase I promoter
	gene expression
	DNA binding
	nucleoplasm
	nucleolus
	cytoplasm
	nucleus

Cell Localization	Nucleus
	Nucleolus

Alias	UBF
	UBF1
	UBF-1
	NOR-90
	nucleolar transcription factor 1
	autoantigen NOR-90
	90-kDa nucleolus organizer region autoantigen
	Tcfubf
	A930005G04Rik
	RP23-461C4.7
	transcription factor UBF
	upstream-binding factor 1
	transcription factor UBF, nucleolar
	UBF1_HUMAN
	Ubtf
	Upstream binding factor 1
	Upstream binding factor I
	upstream binding transcription factor, RNA polymerase I
	RIKEN cDNA A930005G04 gene
	LOC679205
	A930005G04
	UBF I
	Nucleolar transcription factor I
	OTTMUSP00000002630
	OTTMUSP00000002631
	OTTMUSP00000002632
	OTTMUSP00000002633
	OTTMUSP00000002629

Mouse chromosome position	11

OMIM ID	600673

Rat chromosome position	10q32.1

Hugo ID	12511

Human chromosome position	17q21.31
	17q21.3

Swiss-Prot ID	UBF1_HUMAN
	UBF1_RAT

Homologene ID	7970

MGI ID	98512

RGD ID	3927

MedScan ID	7343
	610588

Primary Cell Localization	Nucleus