| URN | urn:agi-llid:7343 |
|---|---|
| Total Entities | 0 |
| Connectivity | 42 |
| Name | Ubtf |
| Description | upstream binding transcription factor, RNA polymerase I |
| Notes | This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011] |
| Ariadne Ontology | Polymerase I transcription |
|---|---|
| UBTF |
| GO Molecular Function | DNA binding |
|---|
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| nucleus |
| GO Biological Process | positive regulation of transcription from RNA polymerase I promoter |
|---|---|
| chromatin silencing at rDNA | |
| regulation of transcription from RNA polymerase I promoter | |
| transcription, DNA-dependent | |
| transcription from RNA polymerase I promoter | |
| transcription initiation from RNA polymerase I promoter | |
| transcription elongation from RNA polymerase I promoter | |
| termination of RNA polymerase I transcription | |
| gene expression |
| Pathway | rRNA Transcription and Processing |
|---|---|
| RNA polymerase I transcription pathway |
| Group | Polymerase I transcription |
|---|---|
| UBTF | |
| positive regulation of transcription from RNA polymerase I promoter | |
| chromatin silencing at rDNA | |
| regulation of transcription from RNA polymerase I promoter | |
| transcription, DNA-dependent | |
| transcription from RNA polymerase I promoter | |
| transcription initiation from RNA polymerase I promoter | |
| transcription elongation from RNA polymerase I promoter | |
| termination of RNA polymerase I transcription | |
| gene expression | |
| DNA binding | |
| nucleoplasm | |
| nucleolus | |
| nucleus |
| MedScan ID | 7343 |
|---|---|
| 610588 |
| Hugo ID | 12511 |
|---|
| Human chromosome position | 17q21.3 |
|---|
| LocusLink ID | 7343 |
|---|---|
| 21429 | |
| 25574 | |
| 679205 |
| Alias | UBF |
|---|---|
| UBF1 | |
| UBF-1 | |
| NOR-90 | |
| nucleolar transcription factor 1 | |
| autoantigen NOR-90 | |
| 90-kDa nucleolus organizer region autoantigen | |
| Tcfubf | |
| A930005G04Rik | |
| RP23-461C4.7 | |
| transcription factor UBF | |
| upstream-binding factor 1 | |
| upstream binding transcription factor, RNA polymerase I | |
| transcription factor UBF, nucleolar | |
| UBF I | |
| UBF1_HUMAN | |
| Ubtf | |
| Upstream binding factor I | |
| OTTMUSP00000002629 | |
| Upstream binding factor 1 | |
| OTTMUSP00000002633 | |
| OTTMUSP00000002632 | |
| A930005G04 | |
| OTTMUSP00000002630 | |
| OTTMUSP00000002631 | |
| Nucleolar transcription factor I | |
| LOC679205 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600673 |
|---|
| Unigene ID | Hs.89781 |
|---|---|
| Mm.2845 | |
| Rn.22469 |
| KEGG ID | hsa:7343 |
|---|---|
| mmu:21429 | |
| rno:25574 |
| Swiss-Prot Accession | P17480 |
|---|---|
| A2AWT6 | |
| A2AWT5 | |
| P25976 | |
| P25977 | |
| P25978 | |
| A8K6R8 |
| GO ID | 0003677 |
|---|---|
| 0010467 | |
| 0045943 | |
| 0006356 | |
| 0006363 | |
| 0006362 | |
| 0006360 | |
| 0006361 | |
| 0005730 | |
| 0005654 | |
| 0000183 | |
| 0005634 | |
| 0006351 |
| PIR ID | A40439 |
|---|---|
| B40439 | |
| S09318 | |
| S18193 |
| Swiss-Prot ID | UBF1_RAT |
|---|---|
| UBF1_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| nucleolus |
| IPI ID | IPI00194555 |
|---|---|
| IPI00388681 | |
| IPI00014533 | |
| IPI00220833 |
| Mouse chromosome position | 11 |
|---|
| Rat chromosome position | 10q32.1 |
|---|
| Homologene ID | 7970 |
|---|
| MGI ID | 98512 |
|---|
| RGD ID | 3927 |
|---|
| Primary Cell Localization | Nucleus |
|---|