| URN | urn:agi-llid:54755 |
|---|---|
| Connectivity | 4 |
| Name | Disp1 |
| Description | dispatched homolog 1 (Drosophila) |
| Notes | The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq] |
| Pathway | Hedgehog signaling pathway |
|---|
| GO Molecular Function | hedgehog receptor activity |
|---|---|
| peptide transporter activity |
| GO Cellular Component | membrane |
|---|---|
| integral to membrane |
| GO Biological Process | multicellular organismal development |
|---|---|
| pattern specification process | |
| embryonic pattern specification | |
| dorsal-ventral pattern formation | |
| determination of left-right symmetry | |
| patched ligand maturation | |
| peptide transport | |
| smoothened signaling pathway |
| Group | multicellular organismal development |
|---|---|
| pattern specification process | |
| embryonic pattern specification | |
| dorsal-ventral pattern formation | |
| determination of left-right symmetry | |
| patched ligand maturation | |
| peptide transport | |
| smoothened signaling pathway | |
| hedgehog receptor activity | |
| peptide transporter activity | |
| membrane | |
| integral to membrane |
| MedScan ID | 54755 |
|---|
| Hugo ID | 19711 |
|---|
| Human chromosome position | 1q41 |
|---|
| LocusLink ID | 54755 |
|---|---|
| 84976 | |
| 68897 | |
| 289338 |
| Alias | DISPA |
|---|---|
| FLJ43740 | |
| MGC13130 | |
| MGC16796 | |
| MGC104180 | |
| DKFZp434I0428 | |
| protein dispatched homolog 1 | |
| dispatched A | |
| 1190008H24Rik | |
| mdispa | |
| twelve-pass transmembrane protein | |
| Icbins | |
| 1190008H24 | |
| DISP I | |
| DISP1 | |
| dispatched homolog 1 | |
| dispatched homolog 1 (Drosophila) | |
| dispatched homolog I | |
| OTTHUMP00000036011 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607502 |
|---|
| Mouse chromosome position | 1 101.2 cM |
|---|
| GO ID | 0008158 |
|---|---|
| 0015197 | |
| 0007368 | |
| 0009953 | |
| 0009880 | |
| 0007225 | |
| 0016021 | |
| 0016020 | |
| 0007275 | |
| 0007389 | |
| 0015833 | |
| 0007224 |
| Rat chromosome position | 13q26 |
|---|
| Swiss-Prot Accession | B3KPN9 |
|---|---|
| Q96F81 | |
| Q3B776 | |
| Q3TDN0 | |
| Q8N7C2 | |
| Q96I92 | |
| Q9H698 | |
| Q9H8H9 | |
| Q9UFA2 | |
| Q3UUL8 | |
| Q80ZZ8 | |
| Q8CGS3 | |
| Q8CIP6 | |
| Q8CIQ9 | |
| Q9CT62 |
| PIR ID | T42693 |
|---|
| Unigene ID | Hs.528817 |
|---|---|
| Mm.358721 | |
| Rn.41748 |
| KEGG ID | hsa:84976 |
|---|---|
| mmu:68897 | |
| rno:289338 |
| Swiss-Prot ID | DISP1_HUMAN |
|---|---|
| DISP1_MOUSE | |
| B3KPN9_HUMAN |
| Cell Localization | Membrane |
|---|
| IPI ID | IPI00172479 |
|---|---|
| IPI00229896 | |
| IPI00875958 | |
| IPI00645249 | |
| IPI00371542 |
| Homologene ID | 14133 |
|---|
| RGD ID | 1307675 |
|---|
| MGI ID | 1916147 |
|---|