| URN | urn:agi-llid:64399 |
|---|---|
| Connectivity | 22 |
| Name | Hhip |
| Description | hedgehog interacting protein |
| Notes | This gene encodes a protein similar to the mouse hedgehog-interacting protein, a regulatory component of the hedgehog signalling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry. [provided by RefSeq] |
| Pathway | Hedgehog signaling pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| cell surface | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| integral to plasma membrane |
| GO Biological Process | neuroblast proliferation |
|---|---|
| organ morphogenesis | |
| dorsal-ventral pattern formation | |
| lung development | |
| signal transduction | |
| negative regulation of signal transduction | |
| negative regulation of smoothened signaling pathway | |
| regulation of fibroblast growth factor receptor signaling pathway | |
| smoothened signaling pathway |
| Ariadne Ontology | Receptors |
|---|
| Group | Receptors |
|---|---|
| extracellular region | |
| catalytic activity | |
| neuroblast proliferation | |
| organ morphogenesis | |
| dorsal-ventral pattern formation | |
| lung development | |
| signal transduction | |
| negative regulation of signal transduction | |
| negative regulation of smoothened signaling pathway | |
| regulation of fibroblast growth factor receptor signaling pathway | |
| smoothened signaling pathway | |
| metal ion binding | |
| zinc ion binding | |
| cell surface | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| integral to plasma membrane |
| MedScan ID | 64399 |
|---|
| Hugo ID | 14866 |
|---|
| Human chromosome position | 4q28-q32 |
|---|
| LocusLink ID | 64399 |
|---|---|
| 15245 | |
| 291936 |
| Alias | HIP |
|---|---|
| FLJ20992 | |
| FLJ90230 | |
| UNQ5825/PRO19644 | |
| hedgehog-interacting protein | |
| Hhip1 | |
| RGD1564108 | |
| hedgehog interacting protein | |
| hedgehog interactive protein | |
| hedgehog-interactive protein | |
| Hh interacting protein | |
| Hh-interacting protein | |
| HHIP | |
| LOC56864 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606178 |
|---|
| Mouse chromosome position | 8 40.0 cM |
|---|
| GO ID | 0003824 |
|---|---|
| 0046872 | |
| 0008270 | |
| 0009953 | |
| 0030324 | |
| 0009968 | |
| 0045879 | |
| 0007405 | |
| 0009887 | |
| 0040036 | |
| 0009986 | |
| 0005737 | |
| 0005576 | |
| 0005887 | |
| 0005886 | |
| 0007165 | |
| 0007224 | |
| 0016020 |
| Rat chromosome position | 19q11 |
|---|
| Swiss-Prot Accession | Q96QV1 |
|---|---|
| Q7TN16 | |
| Q8C0B0 | |
| Q9WU59 | |
| Q6PK09 | |
| Q8NCI7 | |
| Q9BXK3 | |
| Q9H1J4 | |
| Q9H7E7 |
| Unigene ID | Hs.507991 |
|---|---|
| Mm.254493 |
| KEGG ID | hsa:64399 |
|---|---|
| mmu:15245 | |
| rno:291936 |
| Swiss-Prot ID | HHIP_MOUSE |
|---|---|
| HHIP_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Secreted | |
| Cytoplasm | |
| Plasma membrane |
| IPI ID | IPI00458326 |
|---|---|
| IPI00045106 | |
| IPI00556597 | |
| IPI00371465 |
| Homologene ID | 32469 |
|---|
| RGD ID | 1564108 |
|---|
| MGI ID | 1341847 |
|---|