| URN | urn:agi-llid:6608 |
|---|---|
| Connectivity | 131 |
| Name | Smo |
| Description | smoothened homolog (Drosophila) |
| Notes | The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq] |
| Pathway | Hedgehog signaling pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| receptor activity | |
| transmembrane receptor activity | |
| G-protein coupled receptor activity | |
| non-G-protein coupled 7TM receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cilium | |
| neuronal cell body | |
| cytoplasm | |
| integral to membrane |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| osteoblast proliferation | |
| multicellular organismal development | |
| pattern specification process | |
| developmental growth | |
| multicellular organism growth | |
| cerebellar cortex morphogenesis | |
| cell development | |
| cell fate specification | |
| axon extension involved in axon guidance | |
| dorsal-ventral pattern formation | |
| dorsal-ventral neural tube patterning | |
| determination of left-right symmetry | |
| central nervous system development | |
| positive regulation of neuroblast proliferation | |
| facial nerve development | |
| osteoblast differentiation | |
| vasculogenesis | |
| neuron projection regeneration | |
| central nervous system neuron differentiation | |
| heart morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| in utero embryonic development | |
| spermatogenesis | |
| signal transduction | |
| epithelial-mesenchymal cell signaling | |
| positive regulation of smoothened signaling pathway | |
| negative regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| negative regulation of apoptosis | |
| positive regulation of protein import into nucleus | |
| neural crest cell migration | |
| response to organic substance | |
| response to wounding | |
| regulation of gene expression | |
| protein stabilization | |
| cell surface receptor linked signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| Wnt receptor signaling pathway | |
| smoothened signaling pathway | |
| smoothened signaling pathway involved in ventral spinal cord patterning | |
| smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation | |
| negative regulation of DNA binding |
| Ariadne Ontology | GPCR-GqCR |
|---|
| Group | GPCR-GqCR |
|---|---|
| positive regulation of cell proliferation | |
| osteoblast proliferation | |
| multicellular organismal development | |
| pattern specification process | |
| developmental growth | |
| multicellular organism growth | |
| cerebellar cortex morphogenesis | |
| cell development | |
| cell fate specification | |
| axon extension involved in axon guidance | |
| dorsal-ventral pattern formation | |
| dorsal-ventral neural tube patterning | |
| determination of left-right symmetry | |
| central nervous system development | |
| positive regulation of neuroblast proliferation | |
| facial nerve development | |
| osteoblast differentiation | |
| vasculogenesis | |
| neuron projection regeneration | |
| central nervous system neuron differentiation | |
| heart morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| in utero embryonic development | |
| spermatogenesis | |
| signal transduction | |
| epithelial-mesenchymal cell signaling | |
| positive regulation of smoothened signaling pathway | |
| negative regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| negative regulation of apoptosis | |
| positive regulation of protein import into nucleus | |
| neural crest cell migration | |
| response to organic substance | |
| response to wounding | |
| regulation of gene expression | |
| protein stabilization | |
| cell surface receptor linked signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| Wnt receptor signaling pathway | |
| smoothened signaling pathway | |
| smoothened signaling pathway involved in ventral spinal cord patterning | |
| smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation | |
| negative regulation of DNA binding | |
| signal transducer activity | |
| receptor activity | |
| transmembrane receptor activity | |
| G-protein coupled receptor activity | |
| non-G-protein coupled 7TM receptor activity | |
| membrane | |
| plasma membrane | |
| cilium | |
| neuronal cell body | |
| cytoplasm | |
| integral to membrane |
| MedScan ID | 6608 |
|---|
| Hugo ID | 11119 |
|---|
| Human chromosome position | 7q32.3 |
|---|
| LocusLink ID | 6608 |
|---|---|
| 319757 | |
| 25273 |
| Alias | Gx |
|---|---|
| SMOH | |
| smoothened homolog | |
| protein Gx | |
| seven transmembrane helix receptor | |
| bnb | |
| smoothened | |
| E130215L21Rik | |
| bent body | |
| OTTMUSP00000014435 | |
| AU041277 | |
| D13Mgi8 | |
| DNA Segment, Chr 13, Mouse Genome Informatics 8 | |
| E130215L21 | |
| homolog of drosophila Smoothened | |
| Smo | |
| smoothened (Drosophila) homolog | |
| smoothened homolog (Drosophila) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601500 |
|---|
| Mouse chromosome position | 6 7.2 cM |
|---|
| GO ID | 0004930 |
|---|---|
| 0004926 | |
| 0004872 | |
| 0004871 | |
| 0048468 | |
| 0001708 | |
| 0021953 | |
| 0021696 | |
| 0007368 | |
| 0048589 | |
| 0021904 | |
| 0021561 | |
| 0003007 | |
| 0001701 | |
| 0035264 | |
| 0007275 | |
| 0043392 | |
| 0043066 | |
| 0001755 | |
| 0031102 | |
| 0042475 | |
| 0001649 | |
| 0007389 | |
| 0002052 | |
| 0042307 | |
| 0045880 | |
| 0045944 | |
| 0050821 | |
| 0010468 | |
| 0009611 | |
| 0007165 | |
| 0021938 | |
| 0021910 | |
| 0001570 | |
| 0005929 | |
| 0016021 | |
| 0016020 | |
| 0043025 | |
| 0004888 | |
| 0007186 | |
| 0016055 | |
| 0048846 | |
| 0007166 | |
| 0007417 | |
| 0009953 | |
| 0060684 | |
| 0010553 | |
| 0008284 | |
| 0050679 | |
| 0010552 | |
| 0002053 | |
| 0007224 | |
| 0005737 | |
| 0033687 | |
| 0010033 | |
| 0007283 | |
| 0005886 |
| Rat chromosome position | 4q22 |
|---|
| Swiss-Prot Accession | A4D1K5 |
|---|---|
| Q99835 | |
| Q8NH34 | |
| Q9Y2Y5 | |
| Q4VBD5 | |
| Q8BJN8 | |
| P56726 | |
| Q80VD0 | |
| Q8K2P8 | |
| P97698 |
| Unigene ID | Hs.437846 |
|---|---|
| Mm.29279 | |
| Rn.44429 |
| KEGG ID | hsa:6608 |
|---|---|
| mmu:319757 | |
| rno:25273 |
| Swiss-Prot ID | SMO_RAT |
|---|---|
| SMO_HUMAN | |
| A4D1K5_HUMAN | |
| Q8BJN8_MOUSE | |
| Q4VBD5_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00206713 |
|---|---|
| IPI00018471 | |
| IPI00890858 | |
| IPI00341032 |
| Homologene ID | 4115 |
|---|
| RGD ID | 3726 |
|---|
| MGI ID | 108075 |
|---|