Ariadne Genomics Inc. Gli targets translocated Gli Gli proteins Gli modfiying kinases Ptch1 Lrp2 heparan sulfate proteoglycans secreted Hh Hh ligands palmitate GAS1 PTCH2 HHAT Btrc Gli modfiying kinases ---| Gli proteins Sufu ---| Gli proteins Smo_translocated ---| Sufu Sufu Hh ligands ---> secreted Hh Smo_translocated Smo Hh ligands ---- Lrp2 Lrp2 ---- secreted Hh Disp1 HHAT ---> Hh ligands Disp1 ---- Hh ligands secreted Hh ---| Ptch1 Gli proteins ---> translocated Gli translocated Gli ---> Gli targets Smo ---> Smo_translocated Cdon Boc PTCH2 ---| Smo Cdon --+> secreted Hh Boc ---- secreted Hh GAS1 ---- secreted Hh Btrc ---| Gli proteins secreted Hh ---| PTCH2 PTCH2 ---- secreted Hh Ptch1 ---- secreted Hh Hhip ---- secreted Hh Boc --+> secreted Hh GAS1 --+> secreted Hh Hhip ---| secreted Hh Cdon ---- secreted Hh Ptch1 ---| Smo Hhip