| URN | urn:agi-llid:56616 |
|---|---|
| Connectivity | 191 |
| Name | Diablo |
| Description | diablo homolog (Drosophila) |
| Notes | This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. |
| Pathway | Apoptosis |
|---|---|
| intrinsic apoptotic pathway |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| mitochondrion | |
| mitochondrial intermembrane space |
| GO Biological Process | positive regulation of apoptosis |
|---|---|
| induction of apoptosis | |
| induction of apoptosis by oxidative stress | |
| induction of apoptosis via death domain receptors | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| apoptosis |
| Ariadne Ontology | DIABLO |
|---|
| Group | DIABLO |
|---|---|
| positive regulation of apoptosis | |
| induction of apoptosis | |
| induction of apoptosis by oxidative stress | |
| induction of apoptosis via death domain receptors | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| apoptosis | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| mitochondrial intermembrane space |
| MedScan ID | 56616 |
|---|
| Hugo ID | 21528 |
|---|
| Human chromosome position | 12q24.31 |
|---|
| LocusLink ID | 56616 |
|---|---|
| 66593 | |
| 288753 |
| Alias | SMAC |
|---|---|
| SMAC3 | |
| DIABLO-S | |
| FLJ10537 | |
| FLJ25049 | |
| hCG_1782202 | |
| diablo homolog, mitochondrial | |
| 0610041G12Rik | |
| OTTHUMP00000211309 | |
| mitochondrial Smac protein | |
| direct IAP-binding protein with low pI | |
| second mitochondria-derived activator of caspase | |
| AU040403 | |
| 1700006L01Rik | |
| OTTMUSP00000031733 | |
| OTTMUSP00000031734 | |
| OTTMUSP00000031735 | |
| OTTMUSP00000031736 | |
| direct IAP binding protein with low PI | |
| MGC105680 | |
| 0610041G12 | |
| 1700006L01 | |
| DIABLO | |
| diablo homolog | |
| diablo homolog (Drosophila) | |
| direct inhibitor of apoptosis-binding protein with low Pi | |
| Smac-alpha | |
| RIKEN cDNA 0610041G12 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605219 |
|---|
| Mouse chromosome position | 5 |
|---|---|
| 5 F |
| GO ID | 0006919 |
|---|---|
| 0008635 | |
| 0006917 | |
| 0008631 | |
| 0008625 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0006915 | |
| 0043065 | |
| 0005758 | |
| 0005515 |
| Rat chromosome position | 12q16 |
|---|
| Swiss-Prot Accession | Q9NR28 |
|---|---|
| Q6W3F3 | |
| Q502X2 | |
| Q53HB7 | |
| Q542V8 | |
| Q9JIQ3 | |
| Q3TEL3 | |
| Q7TPS3 | |
| Q8R1D8 | |
| Q5RK17 | |
| Q9CZD1 | |
| Q9DCD3 | |
| B2RDQ0 | |
| Q96LV0 | |
| Q9BT11 | |
| Q9HAV6 |
| Unigene ID | Hs.169611 |
|---|---|
| Mm.46716 | |
| Rn.9090 |
| KEGG ID | hsa:56616 |
|---|---|
| mmu:66593 | |
| rno:288753 |
| Swiss-Prot ID | DBLOH_MOUSE |
|---|---|
| DBLOH_HUMAN | |
| Q542V8_MOUSE | |
| Q6W3F3_HUMAN | |
| Q5RK17_RAT |
| Cell Localization | Mitochondrion |
|---|---|
| Cytoplasm |
| IPI ID | IPI00120937 |
|---|---|
| IPI00008418 | |
| IPI00219865 | |
| IPI00605842 | |
| IPI00148255 | |
| IPI00515858 | |
| IPI00794003 | |
| IPI00793399 | |
| IPI00789460 | |
| IPI00153355 | |
| IPI00857447 | |
| IPI00856837 |
| Homologene ID | 10532 |
|---|
| RGD ID | 1310885 |
|---|
| MGI ID | 1913843 |
|---|