| URN | urn:agi-llid:578 |
|---|---|
| Connectivity | 258 |
| Name | Bak1 |
| Description | BCL2-antagonist/killer 1 |
| Notes | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. |
| Pathway | Apoptosis |
|---|---|
| intrinsic apoptotic pathway |
| GO Molecular Function | chaperone binding |
|---|---|
| heat shock protein binding | |
| protein homodimerization activity | |
| BH domain binding | |
| protein heterodimerization activity | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | membrane |
|---|---|
| intracellular | |
| cytosol | |
| endoplasmic reticulum | |
| mitochondrion | |
| mitochondrial outer membrane | |
| mitochondrial membrane | |
| membrane fraction | |
| integral to membrane | |
| pore complex |
| GO Biological Process | cell proliferation |
|---|---|
| negative regulation of cell proliferation | |
| aging | |
| leukocyte homeostasis | |
| response to fungus | |
| endocrine pancreas development | |
| vagina development | |
| brain development | |
| mitochondrial fusion | |
| limb morphogenesis | |
| organ regeneration | |
| post-embryonic camera-type eye morphogenesis | |
| blood vessel remodeling | |
| regulation of cell cycle | |
| positive regulation of calcium ion transport into cytosol | |
| negative regulation of peptidyl-serine phosphorylation | |
| positive regulation of release of cytochrome c from mitochondria | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| regulation of apoptosis | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| regulation of mitochondrial membrane permeability | |
| regulation of mitochondrial membrane potential | |
| reduction of endoplasmic reticulum calcium ion concentration | |
| release of cytochrome c from mitochondria | |
| apoptosis | |
| apoptosis in response to endoplasmic reticulum stress | |
| B cell apoptosis | |
| myeloid cell homeostasis | |
| B cell negative selection | |
| B cell homeostasis | |
| response to drug | |
| response to mycotoxin | |
| response to organic cyclic substance | |
| response to protein stimulus | |
| response to ethanol | |
| response to hydrogen peroxide | |
| response to gamma radiation | |
| response to UV-C | |
| negative regulation of gene expression | |
| establishment or maintenance of transmembrane electrochemical gradient | |
| homeostasis of number of cells | |
| regulation of protein homodimerization activity | |
| regulation of protein heterodimerization activity |
| Ariadne Ontology | Bid |
|---|
| Group | Bid |
|---|---|
| cell proliferation | |
| negative regulation of cell proliferation | |
| aging | |
| leukocyte homeostasis | |
| response to fungus | |
| endocrine pancreas development | |
| vagina development | |
| brain development | |
| mitochondrial fusion | |
| limb morphogenesis | |
| organ regeneration | |
| post-embryonic camera-type eye morphogenesis | |
| blood vessel remodeling | |
| regulation of cell cycle | |
| positive regulation of calcium ion transport into cytosol | |
| negative regulation of peptidyl-serine phosphorylation | |
| positive regulation of release of cytochrome c from mitochondria | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| regulation of apoptosis | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| regulation of mitochondrial membrane permeability | |
| regulation of mitochondrial membrane potential | |
| reduction of endoplasmic reticulum calcium ion concentration | |
| release of cytochrome c from mitochondria | |
| apoptosis | |
| apoptosis in response to endoplasmic reticulum stress | |
| B cell apoptosis | |
| myeloid cell homeostasis | |
| B cell negative selection | |
| B cell homeostasis | |
| response to drug | |
| response to mycotoxin | |
| response to organic cyclic substance | |
| response to protein stimulus | |
| response to ethanol | |
| response to hydrogen peroxide | |
| response to gamma radiation | |
| response to UV-C | |
| negative regulation of gene expression | |
| establishment or maintenance of transmembrane electrochemical gradient | |
| homeostasis of number of cells | |
| regulation of protein homodimerization activity | |
| regulation of protein heterodimerization activity | |
| chaperone binding | |
| heat shock protein binding | |
| protein homodimerization activity | |
| BH domain binding | |
| protein heterodimerization activity | |
| metal ion binding | |
| zinc ion binding | |
| membrane | |
| intracellular | |
| cytosol | |
| endoplasmic reticulum | |
| mitochondrion | |
| mitochondrial outer membrane | |
| mitochondrial membrane | |
| membrane fraction | |
| integral to membrane | |
| pore complex |
| MedScan ID | 578 |
|---|
| Hugo ID | 949 |
|---|
| Human chromosome position | 6p21.3 |
|---|
| LocusLink ID | 578 |
|---|---|
| 12018 | |
| 116502 |
| Alias | BAK |
|---|---|
| CDN1 | |
| BCL2L7 | |
| MGC3887 | |
| BAK-LIKE | |
| MGC117255 | |
| bcl-2 homologous antagonist/killer | |
| bcl2-L-7 | |
| BCL2-like 7 protein | |
| bcl-2-like protein 7 | |
| apoptosis regulator BAK | |
| pro-apoptotic protein BAK | |
| N-Bak | |
| N-BAK1 | |
| Bcl2 homologous antagonist/killer | |
| MGC108627 | |
| BAK I | |
| BAK_HUMAN | |
| BAK1 | |
| BCL2-antagonist/killer 1 | |
| BCL2-antagonist/killer I | |
| BCL2-like 7 | |
| CDN I | |
| cell death inhibitor 1 | |
| cell death inhibitor I | |
| cyclin-dependent kinase inhibitor 1 | |
| OTTHUMP00000016211 | |
| OTTHUMP00000039620 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600516 |
|---|
| Mouse chromosome position | 17 |
|---|---|
| 17 B |
| GO ID | 0046872 |
|---|---|
| 0046982 | |
| 0010248 | |
| 0006917 | |
| 0042981 | |
| 0046902 | |
| 0051881 | |
| 0043497 | |
| 0043496 | |
| 0001836 | |
| 0016020 | |
| 0005741 | |
| 0005739 | |
| 0046930 | |
| 0051400 | |
| 0051087 | |
| 0031072 | |
| 0042803 | |
| 0001783 | |
| 0001782 | |
| 0002352 | |
| 0006919 | |
| 0008635 | |
| 0006915 | |
| 0070059 | |
| 0001974 | |
| 0008283 | |
| 0048872 | |
| 0001776 | |
| 0035108 | |
| 0008053 | |
| 0002262 | |
| 0008285 | |
| 0010629 | |
| 0033137 | |
| 0043065 | |
| 0010524 | |
| 0090200 | |
| 0048597 | |
| 0032471 | |
| 0051726 | |
| 0009620 | |
| 0010332 | |
| 0010046 | |
| 0060068 | |
| 0005829 | |
| 0005783 | |
| 0016021 | |
| 0005622 | |
| 0005624 | |
| 0031966 | |
| 0007568 | |
| 0007420 | |
| 0031018 | |
| 0031100 | |
| 0010225 | |
| 0042493 | |
| 0045471 | |
| 0042542 | |
| 0014070 | |
| 0051789 | |
| 0008270 | |
| 0042802 | |
| 0005515 |
| Rat chromosome position | 20p12 |
|---|
| Swiss-Prot Accession | Q16611 |
|---|---|
| Q8NFF3 | |
| O08734 | |
| Q8C264 | |
| Q91WX5 | |
| Q91ZT2 | |
| Q9JK59 | |
| Q6I9T6 | |
| Q92533 |
| PIR ID | S58873 |
|---|
| Unigene ID | Hs.485139 |
|---|---|
| Mm.2443 | |
| Rn.14598 |
| KEGG ID | hsa:578 |
|---|---|
| mmu:12018 | |
| rno:116502 |
| Swiss-Prot ID | BAK_HUMAN |
|---|---|
| Q9JK59_RAT | |
| Q6I9T6_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Cytoplasm |
| IPI ID | IPI00936392 |
|---|---|
| IPI00202077 | |
| IPI00910780 | |
| IPI00011420 | |
| IPI00386229 | |
| IPI00884320 | |
| IPI00309183 | |
| IPI00314275 | |
| IPI00215557 |
| Homologene ID | 917 |
|---|
| RGD ID | 621635 |
|---|
| MGI ID | 1097161 |
|---|