| URN | urn:agi-llid:27429 |
|---|---|
| Connectivity | 13 |
| Name | Htra2 |
| Description | HtrA serine peptidase 2 |
| Notes | This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. |
| Pathway | intrinsic apoptotic pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| unfolded protein binding | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| cytosol | |
| endoplasmic reticulum | |
| mitochondrion | |
| mitochondrial membrane | |
| mitochondrial intermembrane space | |
| nucleus | |
| integral to membrane |
| GO Biological Process | cell death |
|---|---|
| response to stress | |
| forebrain development | |
| neuron development | |
| regulation of multicellular organism growth | |
| adult locomotory behavior | |
| adult walking behavior | |
| mitochondrion organization | |
| positive regulation of apoptosis | |
| induction of apoptosis by intracellular signals | |
| apoptosis | |
| proteolysis |
| Group | catalytic activity |
|---|---|
| cell death | |
| response to stress | |
| forebrain development | |
| neuron development | |
| regulation of multicellular organism growth | |
| adult locomotory behavior | |
| adult walking behavior | |
| mitochondrion organization | |
| positive regulation of apoptosis | |
| induction of apoptosis by intracellular signals | |
| apoptosis | |
| proteolysis | |
| hydrolase activity | |
| unfolded protein binding | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| cytosol | |
| endoplasmic reticulum | |
| mitochondrion | |
| mitochondrial membrane | |
| mitochondrial intermembrane space | |
| nucleus | |
| integral to membrane |
| MedScan ID | 27429 |
|---|
| Hugo ID | 14348 |
|---|
| Human chromosome position | 2p12 |
|---|
| LocusLink ID | 27429 |
|---|---|
| 64704 | |
| 297376 |
| Alias | OMI |
|---|---|
| PARK13 | |
| PRSS25 | |
| serine protease HTRA2, mitochondrial | |
| OTTHUMP00000202723 | |
| serine protease 25 | |
| protease, serine, 25 | |
| serine proteinase OMI | |
| HtrA-like serine protease | |
| Omi stress-regulated endoprotease | |
| high temperature requirement protein A2 | |
| mnd2 | |
| AI481710 | |
| OTTMUSP00000025609 | |
| OTTMUSP00000025610 | |
| OTTMUSP00000025611 | |
| OTTMUSP00000025612 | |
| OTTMUSP00000025613 | |
| serine protease OMI | |
| motor neuron degeneration 2 | |
| HtrA serine peptidase 2 | |
| HtrA2 | |
| motor neuron degeneration II | |
| PRSS25s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606441 |
|---|---|
| 610297 |
| Mouse chromosome position | 6 34.75 cM |
|---|
| GO ID | 0008233 |
|---|---|
| 0004252 | |
| 0051082 | |
| 0007628 | |
| 0008219 | |
| 0030900 | |
| 0008629 | |
| 0007005 | |
| 0048666 | |
| 0043065 | |
| 0006508 | |
| 0040014 | |
| 0006950 | |
| 0005829 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005758 | |
| 0031966 | |
| 0005739 | |
| 0005634 | |
| 0003824 | |
| 0016787 | |
| 0008236 | |
| 0008344 | |
| 0006915 | |
| 0005515 |
| Rat chromosome position | 4q34 |
|---|
| Swiss-Prot Accession | O43464 |
|---|---|
| Q9JIY5 | |
| Q3TXN0 | |
| Q3UJR3 | |
| Q80V84 | |
| B0BNB9 | |
| Q9R108 | |
| Q9HBZ4 | |
| Q9P0Y3 | |
| Q9P0Y4 |
| Unigene ID | Hs.469045 |
|---|---|
| Hs.724371 | |
| Mm.21880 | |
| Rn.107325 | |
| Hs.716372 |
| KEGG ID | hsa:27429 |
|---|---|
| mmu:64704 | |
| rno:297376 |
| EC Number | 3.4.21.108 |
|---|---|
| 2.4.21.- |
| Swiss-Prot ID | HTRA2_MOUSE |
|---|---|
| HTRA2_HUMAN | |
| B0BNB9_RAT | |
| Q80V84_MOUSE |
| Cell Localization | Mitochondrion intermembrane space |
|---|---|
| Mitochondrion membrane |
| IPI ID | IPI00275992 |
|---|---|
| IPI00001663 | |
| IPI00220542 | |
| IPI00220543 | |
| IPI00220544 | |
| IPI00364298 | |
| IPI00830249 | |
| IPI00830364 | |
| IPI00830476 | |
| IPI00831347 |
| Homologene ID | 113300 |
|---|---|
| 8300 |
| RGD ID | 1308906 |
|---|
| MGI ID | 1928676 |
|---|