| URN | urn:agi-llid:331 |
|---|---|
| Connectivity | 391 |
| Name | Xiap |
| Description | X-linked inhibitor of apoptosis |
| Notes | The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. |
| Pathway | Apoptosis |
|---|---|
| intrinsic apoptotic pathway | |
| ripk2-Xiap |
| GO Molecular Function | ligase activity |
|---|---|
| protease binding | |
| metal ion binding | |
| zinc ion binding | |
| peptidase inhibitor activity | |
| caspase inhibitor activity |
| GO Cellular Component | intracellular |
|---|---|
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | negative regulation of apoptosis |
|---|---|
| negative regulation of neuron apoptosis | |
| anti-apoptosis | |
| negative regulation of caspase activity | |
| modification-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| apoptosis |
| Ariadne Ontology | IAP |
|---|
| Group | IAP |
|---|---|
| negative regulation of apoptosis | |
| negative regulation of neuron apoptosis | |
| anti-apoptosis | |
| negative regulation of caspase activity | |
| modification-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| apoptosis | |
| ligase activity | |
| protease binding | |
| metal ion binding | |
| zinc ion binding | |
| peptidase inhibitor activity | |
| caspase inhibitor activity | |
| intracellular | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| nucleus |
| MedScan ID | 331 |
|---|
| Hugo ID | 592 |
|---|
| Human chromosome position | Xq25 |
|---|
| LocusLink ID | 331 |
|---|---|
| 11798 | |
| 63879 |
| Alias | API3 |
|---|---|
| ILP1 | |
| MIHA | |
| XLP2 | |
| BIRC4 | |
| RP1-315G1.5 | |
| baculoviral IAP repeat-containing protein 4 | |
| IAP-3 | |
| hIAP3 | |
| hIAP-3 | |
| X-linked IAP | |
| IAP-like protein | |
| apoptosis inhibitor 3 | |
| E3 ubiquitin-protein ligase XIAP | |
| inhibitor of apoptosis protein 3 | |
| baculoviral IAP repeat-containing 4 | |
| X-linked inhibitor of apoptosis protein | |
| Aipa | |
| IAP3 | |
| ILP-1 | |
| mXIAP | |
| 1110015C02Rik | |
| RP23-207E14.3 | |
| mIAP3 | |
| mIAP-3 | |
| IAP homolog A | |
| OTTMUSP00000019010 | |
| OTTMUSP00000019023 | |
| OTTMUSP00000019024 | |
| OTTMUSP00000019025 | |
| riap3 | |
| RIAP-3 | |
| apoptosis inhibitor protein 3 | |
| 1110015C02 | |
| apoptosis inhibitor III | |
| baculoviral IAP repeat-containing IV | |
| ILP I | |
| inhibitor of apoptosis (cIAP)-3 | |
| Inhibitor of apoptosis 3 | |
| Inhibitor of apoptosis III | |
| inhibitor of apoptosis protein (IAP)3 | |
| OTTHUMP00000023975 | |
| OTTHUMP00000196392 | |
| X-chromosome linked inhibitor of apoptosis | |
| X-chromosome-linked IAP | |
| XIAP | |
| X-IAP | |
| X-linked inhibitor of apoptosis | |
| Inhibitor of apoptosis protein 3 | |
| Inhibitor of apoptosis protein III |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300079 |
|---|---|
| 300635 |
| Mouse chromosome position | X |
|---|---|
| X A3-A5 |
| GO ID | 0043027 |
|---|---|
| 0016874 | |
| 0046872 | |
| 0030414 | |
| 0008270 | |
| 0006916 | |
| 0006915 | |
| 0006974 | |
| 0005737 | |
| 0005829 | |
| 0005622 | |
| 0002020 | |
| 0043066 | |
| 0043154 | |
| 0043524 | |
| 0005634 | |
| 0048471 | |
| 0019941 | |
| 0005515 | |
| 0004869 | |
| 0006512 |
| Rat chromosome position | Xq11 |
|---|
| Swiss-Prot Accession | P98170 |
|---|---|
| A2BGY6 | |
| Q60989 | |
| Q9R0I6 | |
| Q9EQ04 | |
| Q9EQ05 | |
| Q9ESF0 | |
| Q9NQ14 | |
| D3DTF2 |
| PIR ID | S69544 |
|---|
| Unigene ID | Hs.356076 |
|---|---|
| Mm.259879 | |
| Rn.91239 |
| KEGG ID | hsa:331 |
|---|---|
| mmu:11798 | |
| rno:63879 |
| EC Number | 6.3.2.- |
|---|
| Swiss-Prot ID | XIAP_RAT |
|---|---|
| XIAP_HUMAN | |
| D3DTF2_HUMAN | |
| A2BGY6_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00569380 |
|---|---|
| IPI00303890 | |
| IPI00828483 | |
| IPI00642770 | |
| IPI00852814 | |
| IPI00122773 | |
| IPI00775886 | |
| IPI00206267 |
| Homologene ID | 901 |
|---|
| RGD ID | 620692 |
|---|
| MGI ID | 107572 |
|---|