| URN | urn:agi-llid:54205 |
|---|---|
| Connectivity | 818 |
| Name | Cycs |
| Description | cytochrome c, somatic |
| Notes | This gene encodes cytochrome c, a component of the electron transport chain in mitochondria. The heme group of cytochrome c accepts electrons from the b-c1 complex and transfers electrons to the cytochrome oxidase complex. Cytochrome c is also involved in initiation of apoptosis. Upon release of cytochrome c to the cytoplasm, the protein binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Many cytochrome c pseudogenes exist, scattered throughout the human genome. |
| Pathway | Heme biosynthesis |
|---|---|
| Apoptosis | |
| intrinsic apoptotic pathway |
| GO Molecular Function | electron carrier activity |
|---|---|
| lipid binding | |
| electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity | |
| heme binding | |
| metal ion binding | |
| protein serine-threonine phosphatase activity |
| GO Cellular Component | protein phosphatase type 2A complex |
|---|---|
| soluble fraction | |
| respiratory chain | |
| cytosol | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial intermembrane space | |
| mitochondrial matrix | |
| mitochondrial respiratory chain | |
| nucleus |
| GO Biological Process | transport |
|---|---|
| activation of caspase activity by cytochrome c | |
| electron transport chain | |
| cellular respiration | |
| mitochondrial electron transport, cytochrome c to oxygen | |
| DNA fragmentation involved in apoptotic nuclear change | |
| apoptosis | |
| glial cell apoptosis | |
| response to oxidative stress |
| Ariadne Ontology | Respiratory chain |
|---|---|
| CytC |
| Group | Respiratory chain |
|---|---|
| CytC | |
| electron carrier activity | |
| transport | |
| activation of caspase activity by cytochrome c | |
| electron transport chain | |
| cellular respiration | |
| mitochondrial electron transport, cytochrome c to oxygen | |
| DNA fragmentation involved in apoptotic nuclear change | |
| apoptosis | |
| glial cell apoptosis | |
| response to oxidative stress | |
| lipid binding | |
| electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity | |
| heme binding | |
| metal ion binding | |
| protein serine-threonine phosphatase activity | |
| protein phosphatase type 2A complex | |
| soluble fraction | |
| respiratory chain | |
| cytosol | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial intermembrane space | |
| mitochondrial matrix | |
| mitochondrial respiratory chain | |
| nucleus |
| MedScan ID | 54205 |
|---|
| Hugo ID | 19986 |
|---|
| Human chromosome position | 7p15.3 |
|---|---|
| 7p15.2 |
| LocusLink ID | 54205 |
|---|---|
| 670717 | |
| 25309 | |
| 13067 | |
| 25310 | |
| 13063 |
| Alias | CYC |
|---|---|
| HCS | |
| THC4 | |
| cytochrome c | |
| OTTHUMP00000202044 | |
| OTTHUMP00000202045 | |
| ENSMUSG00000062038 | |
| CYCSA | |
| MGC93634 | |
| cytochrome c, somatic | |
| Cytochrome C, expressed in somatic tissues | |
| cycs | |
| Cytochrome c, Equine Heart | |
| ferricytochrome c | |
| ferrocytochrome c | |
| Gm10108 | |
| horse heart cytochrome c | |
| horse-cytochrome c | |
| LOC214765 | |
| Reduced cytochrome c | |
| T-Cc | |
| RP23-211L7.1 | |
| cytochrome c, testis | |
| OTTMUSP00000014130 | |
| CYCTA | |
| Cytochrome C testis specific | |
| cromoci | |
| myohematin | |
| landrax | |
| cytorest | |
| Cyct |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 123970 |
|---|---|
| 612004 |
| Mouse chromosome position | 5 |
|---|---|
| 2 47.0 cM | |
| 6 23.0 cM |
| GO ID | 0045155 |
|---|---|
| 0020037 | |
| 0046872 | |
| 0004722 | |
| 0006309 | |
| 0008635 | |
| 0006915 | |
| 0045333 | |
| 0022900 | |
| 0006810 | |
| 0005829 | |
| 0005758 | |
| 0005759 | |
| 0005739 | |
| 0005634 | |
| 0000159 | |
| 0070469 | |
| 0009055 | |
| 0008289 | |
| 0034349 | |
| 0006123 | |
| 0006979 | |
| 0005743 | |
| 0005746 | |
| 0005625 | |
| 0005515 | |
| 0005506 | |
| 0042743 | |
| 0043065 |
| Rat chromosome position | 4q24 |
|---|---|
| 3q23 |
| Swiss-Prot Accession | P99999 |
|---|---|
| Q6LER6 | |
| P62898 | |
| P00009 | |
| Q8C2S2 | |
| A4D166 | |
| B2R4I1 | |
| P00001 | |
| Q6NUR2 | |
| Q6NX69 | |
| Q96BV4 | |
| A2ARH7 | |
| P00015 | |
| Q6PBG3 | |
| P10715 |
| PIR ID | A04605 |
|---|---|
| A31764 |
| Unigene ID | Hs.437060 |
|---|---|
| Hs.617193 | |
| Mm.426336 | |
| Rn.2202 | |
| Rn.161841 | |
| Mm.4872 | |
| Rn.88630 | |
| Mm.35389 |
| KEGG ID | hsa:54205 |
|---|---|
| mmu:670717 | |
| rno:25309 | |
| mmu:13067 | |
| rno:25310 | |
| mmu:13063 |
| Swiss-Prot ID | CYC_RAT |
|---|---|
| CYC_HUMAN | |
| CYC2_MOUSE | |
| CYC2_RAT | |
| B2R4I1_HUMAN | |
| A2ARH7_MOUSE |
| Cell Localization | Mitochondrion matrix |
|---|---|
| Mitochondria | |
| Cytoplasm |
| IPI ID | IPI00231864 |
|---|---|
| IPI00465315 | |
| IPI00230033 | |
| IPI00265239 |
| Homologene ID | 105684 |
|---|---|
| 68675 |
| RGD ID | 2451 |
|---|
| MGI ID | 3642431 |
|---|---|
| 88579 | |
| 88578 |