| URN | urn:agi-llid:840 |
|---|---|
| Connectivity | 329 |
| Name | Casp7 |
| Description | caspase 7, apoptosis-related cysteine peptidase |
| Notes | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. |
| Pathway | Apoptosis |
|---|---|
| intrinsic apoptotic pathway | |
| Trail mediated signaling pathway | |
| FasL mediated signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| peptidase activity | |
| cysteine-type peptidase activity | |
| cysteine-type endopeptidase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| endoplasmic reticulum membrane | |
| cytosol | |
| mitochondrial membrane | |
| nucleoplasm | |
| microsome |
| GO Biological Process | aging |
|---|---|
| heart development | |
| induction of apoptosis | |
| regulation of apoptosis | |
| release of cytochrome c from mitochondria | |
| apoptosis | |
| response to UV | |
| proteolysis |
| Ariadne Ontology | CASP3-6-7 |
|---|
| Group | CASP3-6-7 |
|---|---|
| aging | |
| heart development | |
| induction of apoptosis | |
| regulation of apoptosis | |
| release of cytochrome c from mitochondria | |
| apoptosis | |
| response to UV | |
| proteolysis | |
| hydrolase activity | |
| peptidase activity | |
| cysteine-type peptidase activity | |
| cysteine-type endopeptidase activity | |
| soluble fraction | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| cytosol | |
| mitochondrial membrane | |
| nucleoplasm | |
| microsome |
| MedScan ID | 840 |
|---|
| Hugo ID | 1508 |
|---|
| Human chromosome position | 10q25 |
|---|
| LocusLink ID | 840 |
|---|---|
| 12369 | |
| 64026 |
| Alias | MCH3 |
|---|---|
| CMH-1 | |
| ICE-LAP3 | |
| RP11-211N11.6 | |
| caspase-7 | |
| CASP-7 | |
| OTTHUMP00000020511 | |
| OTTHUMP00000020513 | |
| OTTHUMP00000020514 | |
| Lice2 alpha/beta/gamma | |
| caspase 7 isoform delta | |
| apoptotic protease MCH-3 | |
| ICE-like apoptotic protease 3 | |
| caspase 7, apoptosis-related cysteine protease | |
| mCASP-7 | |
| AI314680 | |
| ICE-IAP3 | |
| cysteine protease LICE2 | |
| apoptotic protease MCH III | |
| Casp7 | |
| caspase 7 | |
| caspase 7 alpha, large subunit | |
| caspase 7 delta, large subunit | |
| caspase 7 isoform alpha | |
| caspase 7 isoform beta | |
| caspase 7, apoptosis-related cysteine peptidase | |
| caspase VII | |
| CMH I | |
| ICE- LAP3 | |
| ICE-like apoptotic protease III | |
| mCASP VII | |
| OTTHUMP00000020510 | |
| OTTHUMP00000020512 | |
| caspase 7 alpha, large subunit | |
| caspase 7 delta, large subunit | |
| caspase 7 isoform alpha precursor | |
| mCASP-7s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601761 |
|---|
| Mouse chromosome position | 19 50.0 cM |
|---|
| GO ID | 0004197 |
|---|---|
| 0008234 | |
| 0008233 | |
| 0007568 | |
| 0006915 | |
| 0007507 | |
| 0006508 | |
| 0001836 | |
| 0009411 | |
| 0005737 | |
| 0005829 | |
| 0005789 | |
| 0005792 | |
| 0031966 | |
| 0005654 | |
| 0005625 | |
| 0016787 | |
| 0006917 | |
| 0042981 | |
| 0005515 | |
| 0030693 | |
| 0008632 |
| Rat chromosome position | 1q55 |
|---|
| Swiss-Prot Accession | P55210 |
|---|---|
| Q5SVL2 | |
| P97864 | |
| Q4FJQ4 | |
| Q8C4M5 | |
| O88550 | |
| O08669 | |
| B5BU45 | |
| Q13364 | |
| Q53YD5 | |
| Q5SVL0 | |
| Q5SVL3 | |
| Q96BA0 | |
| D3DRB8 |
| Unigene ID | Hs.9216 |
|---|---|
| Mm.35687 | |
| Rn.53995 |
| KEGG ID | hsa:840 |
|---|---|
| mmu:12369 | |
| rno:64026 |
| EC Number | 3.4.22.60 |
|---|
| Swiss-Prot ID | CASP7_MOUSE |
|---|---|
| CASP7_HUMAN | |
| D3DRB8_HUMAN | |
| Q4FJQ4_MOUSE | |
| O88550_RAT | |
| B5BU45_HUMAN | |
| Q5SVL3_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00130131 |
|---|---|
| IPI00216674 | |
| IPI00216675 | |
| IPI00221307 | |
| IPI00210692 | |
| IPI00647486 | |
| IPI00514222 |
| Homologene ID | 11168 |
|---|
| RGD ID | 620944 |
|---|
| MGI ID | 109383 |
|---|