| URN | urn:agi-llid:842 |
|---|---|
| Connectivity | 656 |
| Name | Casp9 |
| Description | caspase 9, apoptosis-related cysteine peptidase |
| Notes | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. |
| Pathway | Apoptosis |
|---|---|
| intrinsic apoptotic pathway |
| GO Molecular Function | peptide binding |
|---|---|
| hydrolase activity | |
| enzyme activator activity | |
| peptidase activity | |
| cysteine-type peptidase activity | |
| cysteine-type endopeptidase activity |
| GO Cellular Component | intracellular |
|---|---|
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| GO Biological Process | aging |
|---|---|
| positive regulation of apoptosis | |
| induction of apoptosis | |
| positive regulation of neuron apoptosis | |
| regulation of apoptosis | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| response to DNA damage stimulus | |
| apoptosis | |
| glial cell apoptosis | |
| response to antibiotic | |
| response to organic cyclic substance | |
| response to cobalt ion | |
| response to lipopolysaccharide | |
| response to estradiol stimulus | |
| response to UV | |
| proteolysis |
| Ariadne Ontology | CASP9 |
|---|
| Group | CASP9 |
|---|---|
| aging | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| positive regulation of neuron apoptosis | |
| regulation of apoptosis | |
| activation of caspase activity | |
| activation of caspase activity by cytochrome c | |
| response to DNA damage stimulus | |
| apoptosis | |
| glial cell apoptosis | |
| response to antibiotic | |
| response to organic cyclic substance | |
| response to cobalt ion | |
| response to lipopolysaccharide | |
| response to estradiol stimulus | |
| response to UV | |
| proteolysis | |
| peptide binding | |
| hydrolase activity | |
| enzyme activator activity | |
| peptidase activity | |
| cysteine-type peptidase activity | |
| cysteine-type endopeptidase activity | |
| intracellular | |
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| MedScan ID | 842 |
|---|
| Hugo ID | 1511 |
|---|
| Human chromosome position | 1p36.3-p36.1 |
|---|
| LocusLink ID | 842 |
|---|---|
| 12371 | |
| 58918 |
| Alias | MCH6 |
|---|---|
| APAF3 | |
| APAF-3 | |
| ICE-LAP6 | |
| CASPASE-9c | |
| RP11-265F14.3 | |
| caspase-9 | |
| CASP-9 | |
| OTTHUMP00000002324 | |
| apoptotic protease MCH-6 | |
| ICE-like apoptotic protease 6 | |
| apoptotic protease activating factor 3 | |
| apoptotic protease-activating factor 3 | |
| caspase 9, apoptosis-related cysteine protease | |
| AI115399 | |
| AW493809 | |
| RP23-395H4.3 | |
| OTTMUSP00000010525 | |
| Casp9_v1 | |
| Casp-9-CTD | |
| caspase-9 dominant negative form | |
| caspase-9-carboxyl-terminal divergent | |
| 25 kDa caspase-9 dominant negative protein | |
| RNCASP9 | |
| apoptotic protease activating factor III | |
| apoptotic protease MCH VI | |
| Casp9 | |
| caspase 9 | |
| caspase 9 isoform alpha preproprotein | |
| caspase 9 isoform beta preproprotein | |
| caspase 9, apoptosis-related cysteine peptidase | |
| Caspase IX | |
| ICE-like apoptotic protease VI | |
| OTTHUMP00000002322 | |
| OTTHUMP00000002323 | |
| OTTHUMP00000044594 | |
| Pro-Casp9 | |
| procaspase-9 | |
| ICE-like apoptotic protease VI | |
| ICE-like apoptotic protease 6 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602234 |
|---|
| Mouse chromosome position | 4 |
|---|---|
| 4 E1 |
| GO ID | 0004197 |
|---|---|
| 0008047 | |
| 0008233 | |
| 0008635 | |
| 0006915 | |
| 0006508 | |
| 0042981 | |
| 0005829 | |
| 0005622 | |
| 0008234 | |
| 0016787 | |
| 0042277 | |
| 0006919 | |
| 0006917 | |
| 0043065 | |
| 0043525 | |
| 0006974 | |
| 0009411 | |
| 0014070 | |
| 0005737 | |
| 0005739 | |
| 0005634 | |
| 0005625 | |
| 0007568 | |
| 0034349 | |
| 0046677 | |
| 0032025 | |
| 0032355 | |
| 0032496 | |
| 0005515 | |
| 0030693 | |
| 0008632 |
| Rat chromosome position | 5q36 |
|---|
| Swiss-Prot Accession | P55211 |
|---|---|
| Q59GG2 | |
| Q5JRU2 | |
| Q5JRU8 | |
| Q5UGI1 | |
| Q6EV95 | |
| Q8C3Q0 | |
| Q8C3Q9 | |
| Q3TRE1 | |
| Q4FJK5 | |
| Q9R0S9 | |
| Q9R0T0 | |
| Q9JHK1 | |
| Q6EZA5 | |
| Q7TQC1 | |
| Q920G4 | |
| Q99M88 | |
| O95348 | |
| Q53Y70 | |
| Q5JRU9 | |
| Q92852 | |
| Q9BQ62 | |
| Q9UEQ3 | |
| Q9UIJ8 |
| PIR ID | G02635 |
|---|
| Unigene ID | Hs.329502 |
|---|---|
| Mm.88829 | |
| Mm.468800 | |
| Rn.32199 |
| KEGG ID | hsa:842 |
|---|---|
| mmu:12371 | |
| rno:58918 |
| EC Number | 3.4.22.62 |
|---|
| Swiss-Prot ID | CASP9_HUMAN |
|---|---|
| Q8C3Q9_MOUSE | |
| Q9JHK1_RAT | |
| Q8C3Q0_MOUSE | |
| Q53Y70_HUMAN | |
| Q5JRU9_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00023875 |
|---|---|
| IPI00216934 | |
| IPI00387271 | |
| IPI00199583 | |
| IPI00748304 | |
| IPI00552372 | |
| IPI00643258 | |
| IPI00646591 | |
| IPI00648724 | |
| IPI00648892 | |
| IPI00781262 | |
| IPI00395303 |
| Homologene ID | 31024 |
|---|
| RGD ID | 61867 |
|---|
| MGI ID | 1277950 |
|---|