Ariadne Genomics Inc. caspase targets pro-survival Bcl BH3-only Bcl Bax Casp3 ---> caspase targets Casp7 ---> caspase targets Casp3 ---> caspase targets Casp7 ---> caspase targets Casp9 ---> Casp7 Casp9 ---> Casp3 Casp9 ---- Xiap Htra2 ---> released_Htra2 released_Diablo ---- Xiap Casp3 ---- Xiap Casp7 ---- Xiap BH3-only Bcl ---- pro-survival Bcl Apaf1 ---- released_Cycs Diablo ---> released_Diablo Apaf1 ---- Casp9 Cycs ---> released_Cycs released_Htra2 ---> Xiap intracellular stresses Bok ---- pro-survival Bcl Bax ---- pro-survival Bcl Bak1 ---- pro-survival Bcl released_Diablo released_Htra2 Bak1 Bok Htra2 Diablo Xiap Casp3 Casp7 intracellular stresses --+> BH3-only Bcl BH3-only Bcl ---| pro-survival Bcl pro-survival Bcl ---| Bak1 pro-survival Bcl ---| Bax pro-survival Bcl ---| Bok apoptosome --+> Casp9 released_Htra2 ---| Xiap released_Diablo ---| Xiap Xiap ---| Casp7 Xiap ---| Casp3 Casp9 --+> Casp3 Casp9 --+> Casp7 Xiap ---| Casp9 Apaf1 released_Cycs ATP dATP Cycs apoptosome Casp9