| URN | urn:agi-llid:5604 |
|---|---|
| Connectivity | 728 |
| Name | Map2k1 |
| Description | mitogen activated protein kinase kinase 1 |
| Notes | kinase that activates Mapk3 (Erk1) and Mapk1 (Erk2) kinases [RGD] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> NCOR2 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| GDNF -> HSF1 signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling | |
| SELE -> ELK-SRF signaling | |
| NCAM1 -> CREB/ELK-SRF/MYC signaling | |
| PECAM -> SP1 signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| ICAM1 -> AP-1/CREB/ELK-SRF signaling | |
| ThrombopoietinR -> SP1 signaling | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| LeptinR -> ELK-SRF signaling | |
| GHR -> ELK-SRF/MYC signaling | |
| EGFR -> SMAD1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| FGFR -> RUNX2 signaling | |
| KIT -> MITF signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| IL2R -> ELK-SRF/MYC signaling | |
| IL4R -> ELK-SRF/HMGY signaling | |
| IL6R -> CEBP/ELK-SRF signaling | |
| EctodysplasinR -> AP-1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| TNFRSF6 -> HSF1 signaling | |
| B-cell receptor -> AP-1 signaling | |
| CD19 -> AP-1/ELK-SRF signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| ThromboxaneR -> CREB signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| EDG2 -> ELK-SRF signaling | |
| NeuropeptideYR -> ATF/CREB signaling | |
| SerotoninR1 -> FOS signaling | |
| AdenosineR -> AP-1 signaling | |
| AdrenergicRa -> ELK-SRF signaling | |
| AdrenergicRa -> STAT3 signaling | |
| CholecystokininR -> ELK-SRF signaling | |
| GNRHR -> ELK-SRF signaling | |
| GRM1/5 -> CREB signaling | |
| NeurotensinR -> ELK-SRF/AP-1/EGR signaling | |
| OpioidR -> CREB/ELK-SRF/STAT3 signaling | |
| OxytocinR -> ELK-SRF/GATA/AP-1 signaling | |
| ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| SerotoninR2 -> ELK-SRF/GATA4 signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| IL8R -> CREB/EGR signaling | |
| AdrenergicRb -> CREB signaling | |
| AdrenergicRb -> STAT3 signaling | |
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling | |
| TachykininR -> ELK-SRF signaling | |
| VIPR -> CREB/CEBP signaling | |
| DopamineR1 -> CREB/ELK-SRF signaling | |
| FSHR -> CREB/ELK-SRF/GATA4 signaling | |
| GlucagonR -> CREB/ELK-SRF/SP1 signaling | |
| SerotoninR4/6/7 -> NR3C signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| IL1R -> NF-kB signaling | |
| FcIgER -> ELK-SRF signaling | |
| T-cell receptor -> AP-1 signaling | |
| PTPRC -> BCL6 signaling | |
| Notch -> TCF3 signaling | |
| AGER -> CREB/SP1 signaling | |
| UrokinaseR -> ELK-SRF signaling | |
| CholinergicRn -> CREB signaling | |
| CD38 -> NF-kB signaling | |
| the extracellular signal-regulated Raf/Mek/Erk signaling pathway | |
| Copy of 'The extracellular signal-regulated RAF-MEK-ERK signaling pathway' | |
| The extracellular signal-regulated RAF-MEK-ERK signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| non-small cell lung cancer pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| protein kinase binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| Ras GTPase binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein tyrosine kinase activity | |
| MAP kinase kinase activity | |
| receptor signaling protein tyrosine phosphatase activity |
| GO Cellular Component | perikaryon |
|---|---|
| soluble fraction | |
| plasma membrane | |
| axon part | |
| perinuclear region of cytoplasm | |
| cell cortex | |
| cytosol | |
| Golgi apparatus | |
| dendrite cytoplasm | |
| microtubule | |
| dendrite |
| GO Biological Process | cell proliferation |
|---|---|
| negative regulation of cell proliferation | |
| cellular component movement | |
| cell motility | |
| senescence | |
| positive regulation of cell differentiation | |
| labyrinthine layer development | |
| placenta blood vessel development | |
| neuron differentiation | |
| neuron projection morphogenesis | |
| keratinocyte differentiation | |
| regulation of vascular smooth muscle contraction | |
| signal transduction | |
| cell cycle arrest | |
| mitosis | |
| vesicle transport along microtubule | |
| activation of MAPK activity | |
| small GTPase mediated signal transduction | |
| intracellular protein kinase cascade | |
| MAPKKK cascade | |
| Ras protein signal transduction | |
| positive regulation of Ras GTPase activity | |
| positive regulation of RNA elongation from RNA polymerase II promoter | |
| positive regulation of cell migration | |
| negative regulation of homotypic cell-cell adhesion | |
| protein amino acid phosphorylation | |
| Golgi inheritance | |
| chemotaxis | |
| response to oxidative stress | |
| response to glucocorticoid stimulus | |
| response to axon injury | |
| protein heterooligomerization | |
| melanosome transport |
| Ariadne Ontology | MEK1-2 |
|---|
| Group | MEK1-2 |
|---|---|
| cell proliferation | |
| negative regulation of cell proliferation | |
| cellular component movement | |
| cell motility | |
| senescence | |
| positive regulation of cell differentiation | |
| labyrinthine layer development | |
| placenta blood vessel development | |
| neuron differentiation | |
| neuron projection morphogenesis | |
| keratinocyte differentiation | |
| regulation of vascular smooth muscle contraction | |
| signal transduction | |
| cell cycle arrest | |
| mitosis | |
| vesicle transport along microtubule | |
| activation of MAPK activity | |
| small GTPase mediated signal transduction | |
| intracellular protein kinase cascade | |
| MAPKKK cascade | |
| Ras protein signal transduction | |
| positive regulation of Ras GTPase activity | |
| positive regulation of RNA elongation from RNA polymerase II promoter | |
| positive regulation of cell migration | |
| negative regulation of homotypic cell-cell adhesion | |
| protein amino acid phosphorylation | |
| Golgi inheritance | |
| chemotaxis | |
| response to oxidative stress | |
| response to glucocorticoid stimulus | |
| response to axon injury | |
| protein heterooligomerization | |
| melanosome transport | |
| nucleotide binding | |
| transferase activity | |
| protein kinase binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| Ras GTPase binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein tyrosine kinase activity | |
| MAP kinase kinase activity | |
| receptor signaling protein tyrosine phosphatase activity | |
| perikaryon | |
| soluble fraction | |
| plasma membrane | |
| axon part | |
| perinuclear region of cytoplasm | |
| cell cortex | |
| cytosol | |
| Golgi apparatus | |
| dendrite cytoplasm | |
| microtubule | |
| dendrite |
| MedScan ID | 5604 |
|---|
| Hugo ID | 6840 |
|---|
| Human chromosome position | 15q22.1-q22.33 |
|---|
| LocusLink ID | 5604 |
|---|---|
| 26395 | |
| 170851 | |
| 19101 | |
| 326395 | |
| 533199 | |
| 406728 | |
| 336209 | |
| 336276 |
| Alias | MEK1 |
|---|---|
| MKK1 | |
| MAPKK1 | |
| PRKMK1 | |
| dual specificity mitogen-activated protein kinase kinase 1 | |
| MEK 1 | |
| MAPKK 1 | |
| MAPK/ERK kinase 1 | |
| MAP kinase kinase 1 | |
| ERK activator kinase 1 | |
| protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) | |
| MEKK1 | |
| OTTMUSP00000018355 | |
| mitogen activated protein kinase kinase 1 | |
| protein kinase, mitogen activated, kinase 1, p45 | |
| MAP kinase/Erk kinase 1 | |
| mitogen-activated protein kinase kinase 1 | |
| Dual specificity mitogen-activated protein kinase kinase I | |
| ERK activator kinase I | |
| ERK kinase 1 | |
| ERK kinase I | |
| MAP kinase kinase 1 , splice form A | |
| MAP kinase kinase I | |
| MAP kinase/Erk kinase I | |
| Map2k I | |
| MAP2K1 | |
| MAPK kinase 1 | |
| MAPK kinase I | |
| MAPK/ERK kinase I | |
| MAPKK I | |
| MEK I | |
| mitogen-activated protein kinase kinase I | |
| MKK I | |
| MPK I | |
| MPK1 | |
| MPK1_HUMAN | |
| PRKMK I | |
| PRKMK1s | |
| MAPKK1s | |
| protein kinase, mitogen-activated, kinase I | |
| protein kinase, mitogen-activated, kinase 1 | |
| PRKMK Is | |
| MAPKK Is | |
| Edpm9 | |
| Map3k1 | |
| Estrogen-dependent pituitary mass QTL 9 | |
| MAPKKK1 | |
| oestrogen-dependent pituitary mass qtl, chromosome 9 | |
| Estrogen-dependent pituitary mass QTL, Chromosome 9 | |
| Estrogen-dependent pituitary mass QTL IX | |
| kinase, mitogen activated, kinase 1, p | |
| Mekk | |
| oestrogen-dependent pituitary mass qtl, chromosome IX | |
| kinase 1 | |
| kinase 1 (MAP kinase kinase 1) | |
| mitogen-activated | |
| protein kinase | |
| fj61b01 | |
| si:ch211-242m18.2 | |
| wu:fj61b01 | |
| CH73-94F11.4 | |
| MGC113988 | |
| chromosome | |
| scaffold | |
| wu:fj56a12 | |
| zgc:56557 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio | |
| Human |
| OMIM ID | 176872 |
|---|---|
| 115150 | |
| 61385 | |
| OMIM:176872 |
| Mouse chromosome position | 9 36.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0004708 | |
| 0017016 | |
| 0031435 | |
| 0000166 | |
| 0004672 | |
| 0004674 | |
| 0004713 | |
| 0004728 | |
| 0016740 | |
| 0048313 | |
| 0007265 | |
| 0000187 | |
| 0007050 | |
| 0048870 | |
| 0006928 | |
| 0006935 | |
| 0030216 | |
| 0060711 | |
| 0032402 | |
| 0007067 | |
| 0008285 | |
| 0034111 | |
| 0030182 | |
| 0048812 | |
| 0060674 | |
| 0032968 | |
| 0032320 | |
| 0045597 | |
| 0030335 | |
| 0051291 | |
| 0003056 | |
| 0048678 | |
| 0051384 | |
| 0006979 | |
| 0010149 | |
| 0007165 | |
| 0007264 | |
| 0047496 | |
| 0005794 | |
| 0033267 | |
| 0005938 | |
| 0005829 | |
| 0032839 | |
| 0005874 | |
| 0043204 | |
| 0048471 | |
| 0005886 | |
| 0005625 | |
| 0016301 | |
| 0019901 | |
| 0000165 | |
| 0008283 | |
| 0006468 | |
| 0030425 | |
| 0007243 | |
| 0005515 | |
| 0043406 | |
| 0005575 |
| Rat chromosome position | 8q24 |
|---|
| Swiss-Prot Accession | A4QPA9 |
|---|---|
| Q02750 | |
| P31938 | |
| Q3TMJ8 | |
| Q3TMW4 | |
| Q3U3F4 | |
| Q3UK05 | |
| Q9JJE1 | |
| Q01986 | |
| Q5EBD5 | |
| MP2K1_HUMAN |
| PIR ID | I59571 |
|---|---|
| A45100 | |
| JN0840 |
| Unigene ID | Hs.145442 |
|---|---|
| Mm.248907 | |
| Rn.5850 | |
| Mm.426740 | |
| Hs.132311 | |
| Mm.435672 | |
| Bt.29185 | |
| Dr.107100 | |
| Dr.81130 | |
| Mm.456154 | |
| Mm.465469 |
| KEGG ID | hsa:5604 |
|---|---|
| mmu:26395 | |
| rno:170851 |
| EC Number | 2.7.12.2 |
|---|---|
| 2.7.1.- |
| Swiss-Prot ID | MP2K1_MOUSE |
|---|---|
| MP2K1_HUMAN | |
| MP2K1_RAT | |
| A4QPA9_HUMAN | |
| Q3TMJ8_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00466610 |
|---|---|
| IPI00219604 | |
| IPI00231247 | |
| IPI00797850 |
| Homologene ID | 2063 |
|---|
| RGD ID | 70495 |
|---|
| MGI ID | 1346866 |
|---|---|
| 102562 |
| Microarray ID | 92585_at |
|---|---|
| 1367760_at | |
| d14591_s_at | |
| l04485mrna_s_at | |
| rc_ai178835_at | |
| A_42_P638191 | |
| 1416351_at | |
| 99707_at | |
| l02526_s_at | |
| A_51_P241074 | |
| L05624 | |
| 202670_at | |
| 60945_at | |
| 1130_at | |
| 1844_s_at | |
| L05624_s_at | |
| L11284_at | |
| 214592_s_at | |
| A_32_P406652 | |
| A_32_P189110 | |
| A_23_P20248 | |
| A_14_P100756 | |
| A_14_P118260 | |
| A_14_P128795 |
| FunctionalClass | ATP binding |
|---|---|
| MAP kinase kinase | |
| nucleotide binding | |
| protein binding | |
| protein serine/threonine kinase | |
| protein-tyrosine kinase | |
| transferase | |
| kinase | |
| protein kinase |
| Mus musculus Chromosome position | 9 36.0 cM |
|---|
| Source | Curated |
|---|---|
| GO component |
| Homo sapiens Chromosome position | 15q22.1-q22.33 |
|---|
| Hugo Symbol | MAP2K1 |
|---|
| Bos taurus Chromosome position | 10 |
|---|
| Rattus norvegicus Chromosome position | 8q24 |
|---|