| URN | urn:agi-llid:5605 |
|---|---|
| Connectivity | 172 |
| Name | Map2k2 |
| Description | mitogen activated protein kinase kinase 2 |
| Notes | a dual-specificity protein kinase that activates the Erk1 and Erk2 kinases [RGD] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| GDNF -> HSF1 signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling | |
| SELE -> ELK-SRF signaling | |
| NCAM1 -> CREB/ELK-SRF/MYC signaling | |
| PECAM -> SP1 signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| ICAM1 -> AP-1/CREB/ELK-SRF signaling | |
| ThrombopoietinR -> SP1 signaling | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| LeptinR -> ELK-SRF signaling | |
| GHR -> ELK-SRF/MYC signaling | |
| EGFR -> SMAD1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| FGFR -> RUNX2 signaling | |
| KIT -> MITF signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| IL2R -> ELK-SRF/MYC signaling | |
| IL4R -> ELK-SRF/HMGY signaling | |
| IL6R -> CEBP/ELK-SRF signaling | |
| EctodysplasinR -> AP-1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| TNFRSF6 -> HSF1 signaling | |
| B-cell receptor -> AP-1 signaling | |
| CD19 -> AP-1/ELK-SRF signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| ThromboxaneR -> CREB signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| EDG2 -> ELK-SRF signaling | |
| NeuropeptideYR -> ATF/CREB signaling | |
| SerotoninR1 -> FOS signaling | |
| AdenosineR -> AP-1 signaling | |
| AdrenergicRa -> ELK-SRF signaling | |
| AdrenergicRa -> STAT3 signaling | |
| CholecystokininR -> ELK-SRF signaling | |
| GNRHR -> ELK-SRF signaling | |
| GRM1/5 -> CREB signaling | |
| NeurotensinR -> ELK-SRF/AP-1/EGR signaling | |
| OpioidR -> CREB/ELK-SRF/STAT3 signaling | |
| OxytocinR -> ELK-SRF/GATA/AP-1 signaling | |
| ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| SerotoninR2 -> ELK-SRF/GATA4 signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| IL8R -> CREB/EGR signaling | |
| AdrenergicRb -> CREB signaling | |
| AdrenergicRb -> STAT3 signaling | |
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling | |
| TachykininR -> ELK-SRF signaling | |
| VIPR -> CREB/CEBP signaling | |
| DopamineR1 -> CREB/ELK-SRF signaling | |
| FSHR -> CREB/ELK-SRF/GATA4 signaling | |
| GlucagonR -> CREB/ELK-SRF/SP1 signaling | |
| SerotoninR4/6/7 -> NR3C signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| IL1R -> NF-kB signaling | |
| FcIgER -> ELK-SRF signaling | |
| T-cell receptor -> AP-1 signaling | |
| PTPRC -> BCL6 signaling | |
| Notch -> TCF3 signaling | |
| AGER -> CREB/SP1 signaling | |
| UrokinaseR -> ELK-SRF signaling | |
| CholinergicRn -> CREB signaling | |
| CD38 -> NF-kB signaling | |
| the extracellular signal-regulated Raf/Mek/Erk signaling pathway | |
| Copy of 'The extracellular signal-regulated RAF-MEK-ERK signaling pathway' | |
| The extracellular signal-regulated RAF-MEK-ERK signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein tyrosine kinase activity | |
| MAP kinase kinase activity |
| GO Cellular Component | extracellular region |
|---|---|
| soluble fraction | |
| cell cortex | |
| cytosol |
| GO Biological Process | small GTPase mediated signal transduction |
|---|---|
| MAPKKK cascade | |
| Ras protein signal transduction | |
| protein amino acid phosphorylation |
| Ariadne Ontology | MEK1-2 |
|---|
| Group | MEK1-2 |
|---|---|
| extracellular region | |
| small GTPase mediated signal transduction | |
| MAPKKK cascade | |
| Ras protein signal transduction | |
| protein amino acid phosphorylation | |
| nucleotide binding | |
| transferase activity | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein tyrosine kinase activity | |
| MAP kinase kinase activity | |
| soluble fraction | |
| cell cortex | |
| cytosol |
| MedScan ID | 5605 |
|---|
| Hugo ID | 6842 |
|---|
| Human chromosome position | 19p13.3 |
|---|
| LocusLink ID | 5605 |
|---|---|
| 26396 | |
| 58960 | |
| 29570 | |
| 19102 | |
| 103107 | |
| 619546 | |
| 510434 | |
| 474377 | |
| 563181 |
| Alias | MEK2 |
|---|---|
| MKK2 | |
| MAPKK2 | |
| PRKMK2 | |
| FLJ26075 | |
| dual specificity mitogen-activated protein kinase kinase 2 | |
| MEK 2 | |
| MAPKK 2 | |
| MAPK/ERK kinase 2 | |
| OTTHUMP00000165827 | |
| MAP kinase kinase 2 | |
| ERK activator kinase 2 | |
| mitogen-activated protein kinase kinase 2, p45 | |
| MK2 | |
| AA589381 | |
| OTTMUSP00000018442 | |
| OTTMUSP00000018443 | |
| MAP kinase/Erk kinase | |
| mitogen activated protein kinase kinase 2 | |
| protein kinase, mitogen activated, kinase 2, p45 | |
| cardiofaciocutaneous syndrome gene | |
| Dual specificity mitogen-activated protein kinase kinase II | |
| ERK activator kinase II | |
| ERK kinase 2 | |
| ERK kinase II | |
| LOC619546 | |
| LOC82591 | |
| LOC85511 | |
| MAP kinase kinase II | |
| Map2k2 | |
| MAPK kinase 2 | |
| MAPK kinase II | |
| MAPK/ERK kinase II | |
| mitogen-activated protein kinase kinase II | |
| p45 MAPK kinase | |
| p45 MAPKK | |
| mitogen-activated protein kinase kinase 2 | |
| PRKMK2s | |
| MAPKK2s | |
| CFC syndrome | |
| cardiofaciocutaneous syndrome | |
| dual specificity | |
| kinase, mitogen activated, kinase 2, p | |
| LOC563181 | |
| MGC123171 | |
| chromosome | |
| scaffold | |
| zgc:123171 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 601263 |
|---|---|
| 115150 | |
| OMIM:601263 |
| Mouse chromosome position | 10 43.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0004708 | |
| 0000166 | |
| 0004674 | |
| 0004713 | |
| 0016740 | |
| 0000165 | |
| 0007265 | |
| 0006468 | |
| 0007264 | |
| 0005938 | |
| 0005829 | |
| 0005576 | |
| 0005625 | |
| 0016301 | |
| 0004672 | |
| 0005515 | |
| 0005575 |
| Rat chromosome position | 7q11 |
|---|
| Swiss-Prot Accession | P36507 |
|---|---|
| Q6ZPC5 | |
| Q7Z370 | |
| Q3USU3 | |
| Q8CB46 | |
| Q9D7B0 | |
| Q3UPM3 | |
| Q63932 | |
| Q91YS7 | |
| P36506 | |
| A0JN15 |
| PIR ID | A48081 |
|---|---|
| A46723 |
| Unigene ID | Hs.465627 |
|---|---|
| Mm.275436 | |
| Rn.82693 | |
| Hs.366546 | |
| Bt.8367 | |
| Dr.104532 |
| KEGG ID | hsa:5605 |
|---|---|
| mmu:26396 | |
| rno:58960 |
| EC Number | 2.7.12.2 |
|---|---|
| 2.7.1.- |
| Swiss-Prot ID | MP2K2_RAT |
|---|---|
| MP2K2_HUMAN | |
| Q9D7B0_MOUSE | |
| Q3USU3_MOUSE | |
| Q8CB46_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Extracellular |
| IPI ID | IPI00231331 |
|---|---|
| IPI00003783 | |
| IPI00755513 | |
| IPI00776164 | |
| IPI00443029 | |
| IPI00795187 | |
| IPI00135708 | |
| IPI00653120 | |
| IPI00782344 |
| Homologene ID | 48591 |
|---|
| RGD ID | 61888 |
|---|
| MGI ID | 1346867 |
|---|---|
| 2143493 | |
| 101840 |
| Microarray ID | 92543_at |
|---|---|
| 202424_at |
| FunctionalClass | ATP binding |
|---|---|
| nucleotide binding | |
| protein serine/threonine kinase | |
| protein-tyrosine kinase | |
| transferase | |
| kinase | |
| protein kinase | |
| protein binding |
| Mus musculus Chromosome position | 10 43.0 cM |
|---|---|
| 10 |
| Source | Curated |
|---|---|
| GO component |
| KEGG pathway | Chronic myeloid leukemia |
|---|---|
| Endometrial cancer | |
| ErbB signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Gap junction | |
| Glioma | |
| GnRH signaling pathway | |
| Insulin signaling pathway | |
| Long-term depression | |
| Long-term potentiation | |
| MAPK signaling pathway | |
| Melanogenesis | |
| Melanoma | |
| Natural killer cell mediated cytotoxicity | |
| Non-small cell lung cancer | |
| Regulation of actin cytoskeleton | |
| Renal cell carcinoma | |
| Thyroid cancer | |
| VEGF signaling pathway |
| Homo sapiens Chromosome position | 19p13.3 |
|---|---|
| 12q24 |
| Bos taurus Chromosome position | 7 |
|---|
| Rattus norvegicus Chromosome position | 7q11 |
|---|