| URN | urn:agi-llid:1848 |
|---|---|
| Connectivity | 113 |
| Name | Dusp6 |
| Description | dual specificity phosphatase 6 |
| Notes | protein tyrosine phosphatase involved in regulation of mitogen-activated protein kinase (MAPK) [RGD] |
| Pathway | the extracellular signal-regulated Raf/Mek/Erk signaling pathway |
|---|---|
| Copy of 'The extracellular signal-regulated RAF-MEK-ERK signaling pathway' | |
| The extracellular signal-regulated RAF-MEK-ERK signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein tyrosine-serine-threonine phosphatase activity | |
| MAP kinase tyrosine-serine-threonine phosphatase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| nucleoplasm |
| GO Biological Process | cell differentiation |
|---|---|
| regulation of heart growth | |
| negative regulation of ERK1 and ERK2 cascade | |
| inactivation of MAPK activity | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of apoptosis | |
| protein amino acid dephosphorylation | |
| peptidyl-tyrosine dephosphorylation | |
| dephosphorylation | |
| response to drug | |
| response to nitrosative stress | |
| response to organic cyclic substance | |
| response to growth factor stimulus |
| Ariadne Ontology | DUSP |
|---|
| Group | DUSP |
|---|---|
| cell differentiation | |
| regulation of heart growth | |
| negative regulation of ERK1 and ERK2 cascade | |
| inactivation of MAPK activity | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of apoptosis | |
| protein amino acid dephosphorylation | |
| peptidyl-tyrosine dephosphorylation | |
| dephosphorylation | |
| response to drug | |
| response to nitrosative stress | |
| response to organic cyclic substance | |
| response to growth factor stimulus | |
| hydrolase activity | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein tyrosine-serine-threonine phosphatase activity | |
| MAP kinase tyrosine-serine-threonine phosphatase activity | |
| soluble fraction | |
| cytoplasm | |
| nucleoplasm |
| MedScan ID | 1848 |
|---|
| Hugo ID | 3072 |
|---|
| Human chromosome position | 12q22-q23 |
|---|
| LocusLink ID | 1848 |
|---|---|
| 67603 | |
| 116663 | |
| 515310 | |
| 353314 | |
| 326097 | |
| 572990 |
| Alias | MKP3 |
|---|---|
| PYST1 | |
| dual specificity protein phosphatase 6 | |
| MAP kinase phosphatase 3 | |
| dual specificity protein phosphatase PYST1 | |
| serine/threonine specific protein phosphatase | |
| mitogen-activated protein kinase phosphatase 3 | |
| MKP-3 | |
| MGC98540 | |
| 1300019I03Rik | |
| MGC93276 | |
| 1300019I03 | |
| dual specificity phosphatase 6 | |
| dual specificity phosphatase VI | |
| Dual specificity protein phosphatase PYST I | |
| DUSP6 | |
| MAP kinase phosphatase III | |
| MAPK phosphatase 3 | |
| MAPK phosphatase III | |
| Mitogen-activated protein kinase phosphatase III | |
| MKP III | |
| MKP IIIs | |
| PYST I | |
| rVH6 | |
| MAP kinase phosphatase III | |
| MAP kinase phosphatase 3 | |
| fd99d09 | |
| wu:fd99d09 | |
| DKEY-164B12.1 | |
| chromosome | |
| etID14116.25 | |
| scaffold | |
| LOC572990 | |
| similar to MAP kinase phosphatase 3; DUSP6 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 602748 |
|---|
| Mouse chromosome position | 10 |
|---|---|
| 10 C3 |
| GO ID | 0017017 |
|---|---|
| 0016787 | |
| 0004725 | |
| 0030154 | |
| 0000188 | |
| 0070373 | |
| 0035335 | |
| 0043065 | |
| 0042493 | |
| 0070848 | |
| 0051409 | |
| 0014070 | |
| 0005737 | |
| 0005654 | |
| 0016791 | |
| 0004721 | |
| 0008138 | |
| 0016311 | |
| 0001933 | |
| 0006470 | |
| 0060420 | |
| 0005625 | |
| 0004722 | |
| 0005515 | |
| 0000074 | |
| 0000158 | |
| 0000163 | |
| 0004723 | |
| 0004724 | |
| 0008420 | |
| 0015071 | |
| 0017018 | |
| 0030357 | |
| 0009953 | |
| 0016301 | |
| 0040036 | |
| 0042663 |
| Rat chromosome position | 7q13 |
|---|
| Swiss-Prot Accession | Q16828 |
|---|---|
| Q53GP9 | |
| Q689E8 | |
| Q9DBB1 | |
| Q3U786 | |
| Q3UB30 | |
| Q3UG02 | |
| Q64346 | |
| O75109 | |
| Q53Y75 | |
| Q9BSH6 | |
| Q542I5 | |
| Q9D7L4 |
| Unigene ID | Hs.298654 |
|---|---|
| Mm.1791 | |
| Rn.4313 | |
| Bt.11909 | |
| Dr.120762 | |
| Dr.16301 |
| KEGG ID | hsa:1848 |
|---|---|
| mmu:67603 | |
| rno:116663 |
| EC Number | 3.1.3.48 |
|---|---|
| 3.1.3.16 |
| Swiss-Prot ID | DUS6_RAT |
|---|---|
| DUS6_HUMAN | |
| DUS6_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00211712 |
|---|---|
| IPI00004390 | |
| IPI00335706 | |
| IPI00119494 | |
| IPI00780285 |
| Homologene ID | 55621 |
|---|
| RGD ID | 70978 |
|---|
| MGI ID | 1914853 |
|---|
| Microarray ID | 161536_r_at |
|---|---|
| 93285_at |
| FunctionalClass | MAP kinase phosphatase |
|---|---|
| hydrolase | |
| protein binding | |
| protein serine/threonine phosphatase | |
| protein tyrosine phosphatase | |
| phosphoprotein phosphatase | |
| protein tyrosine/serine/threonine phosphatase | |
| CTD phosphatase | |
| calcium-dependent protein serine/threonine phosphatase | |
| magnesium-dependent protein serine/threonine phosphatase | |
| myosin phosphatase | |
| protein phosphatase type 1 | |
| protein phosphatase type 2A | |
| protein phosphatase type 2B | |
| protein phosphatase type 2C | |
| MAP kinase tyrosine/serine/threonine phosphatase | |
| kinase | |
| phosphoric monoester hydrolase |
| Mus musculus Chromosome position | 10 C3 |
|---|
| Source | Curated |
|---|---|
| GO component |
| KEGG pathway | MAPK signaling pathway |
|---|
| Homo sapiens Chromosome position | 12q22-q23 |
|---|
| Bos taurus Chromosome position | 5 |
|---|
| Danio rerio Chromosome position | LG 25 |
|---|
| Rattus norvegicus Chromosome position | 7q13 |
|---|