ProtModification Map2k1 --+> Mapk3

URN urn:agi-ProtModification:inout-urn:agi-llid:5604:out-urn:agi-llid:5595::positive:phosphorylation
References 360
Connectivity 2
Effect positive
Mechanism phosphorylation
Original # of References 54
TextRef info:pmid/11134045
MedLine Reference 11134045
Sentence MEK1 interacts with ERK1 via a conserved docking site in MEK
TextRef info:pmid/11716472#abs:6
PubYear 2001
MedlineTA Arch Biochem Biophys
MedLine Reference 11716472:5
Sentence MEK1 phosphorylates ERK1/ERK2, which belong to the family of mitogen-activated protein kinases.
CellType Myocytes, Smooth Muscle
Organ Aorta
Organism Rattus norvegicus
TextRef info:pmid/11496823#abs:3
MedLine Reference 11496823:2
Sentence PD98059, a specific inhibitor of MEK-1 which phosphorylates p44/p42 MAP kinase, strongly suppressed the thapsigargin-induced histamine production, the increase in HDC mRNA level and 74-kDa HDC protein expression.
TextRef info:pmid/11673351#abs:6
PubYear 2001
MedlineTA Circulation
MedLine Reference 11673351:5
Sentence IGF-I-stimulation was followed by a phosphatidylinositol-3-OH-kinase-dependent phosphorylation of AKT and BAD and an MEK1-dependent phosphorylation of extracellular signal-regulated kinase (ERK) 1 and ERK2.
TextMods 36: 'PI3K' -> 'phosphatidylinositol-3-OH-kinase'
CellType Myocytes, Cardiac
TextRef info:pmid/9159118#abs:4
MedLine Reference 9159118:3
Sentence Inhibiting activation of ERK1 and ERK2 with the MEK1/2 inhibitor PD98059 has no effect on insulin secretion, indicating that ERK activity is not necessary for secretion under these conditions.
TextRef info:pmid/10711350#abs:5
MedLine Reference 10711350:4
Sentence PD98059, a specific inhibitor of MEK-1 which phosphorylates p44/p42 MAP kinase, strongly suppressed both the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production, whereas SB203580, a specific inhibitor of p38 MAP kinase, inhibited them only partially. 6.
TextRef info:pmid/8557975#abs:2
PubYear 1996
MedlineTA J Immunol
MedLine Reference 8557975:1
Sentence Active Raf-1 phosphorylates and activates the mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and activates the mitogen-activated protein kinases/extracellular signal regulated kinases, ERK1 and ERK2.
TextMods 72: '(MAP) ' -> '' 181: 'MAP ' -> 'mitogen-activated protein '
TextRef info:pmid/10958792#abs:6
MedLine Reference 10958792:5
Sentence In the ovarian carcinoma cell line A2780, inhibition of ERK1/2 activation with the mitogen-activated protein kinase/ERK kinase 1 (MEK1) inhibitor PD98059 resulted in decreased p53 protein half-life and diminished accumulation of p53 protein during exposure to cisplatin.
TextRef info:pmid/14699120#abs:8
PubYear 2004
MedlineTA J Biol Chem
MedLine Reference 14699120:7
Sentence To our knowledge, this is the first report that p56(lck) in presence of hypoxia/reoxygenation regulates MEK-1-dependent ERK1/2 phosphorylation and uPA secretion through tyrosine phosphorylation of EGF receptor, and it further demonstrates that all of these signaling molecules ultimately control the motility of breast cancer cells.
TextMods 72: 'H/R ' -> 'hypoxia/reoxygenation '
TextRef info:pmid/10625698#body:209
MedLine Reference 10625698:1208
Sentence Activated MEK1/2 phosphorylates and activates ERK1/2.
TextRef info:pmid/12110546#body:197
MedLine Reference 12110546:1196
Sentence ERK1/2 activation is regulated by the upstream enzyme MEK1/2.
TextRef info:pmid/10781613#body:230
MedLine Reference 10781613:1229
Sentence MEK1/2 phosphorylates ERK1/2 exclusively ( 22 ).
TextRef info:pmid/12594256#body:247
MedLine Reference 12594256:1246
Sentence ERK1/2 is activated by the upstream kinase MAPK kinase 1 ( 39 ).
TextRef info:pmid/11342545#body:132
MedLine Reference 11342545:1131
Sentence ERK1 and ERK2 are activated by dual specificity kinases MEK1 and MEK2.
TextRef info:pmid/15044319#body:119
PubYear 2004
MedlineTA Circ Res
MedLine Reference 15044319:1118
Sentence Western blot analysis using anti-phospho-ERK antibody revealed that ca-MEK1 phosphorylated ERK1/2.
TextRef info:pmid/19651986#body:145
PubYear 2009
MedlineTA Genes Dev
MedLine Reference 19651986:1144
Sentence Endogenous MEK1b is activated by nocodazole and specifically phosphorylates Extracellular signal-regulated kinase1c.
TextMods 76: 'ERK' -> 'Extracellular signal-regulated kinase'
TextRef info:pmid/11457869#body:82
PubYear 2001
MedlineTA J Clin Invest
MedLine Reference 11457869:1081
Sentence PD98059 can specifically inhibit MEK1 and MEK2, two enzymes that phosphorylate and activate ERK1 and ERK2.
TextRef info:pmid/14871928#body:74
PubYear 2004
MedlineTA Genes Dev
MedLine Reference 14871928:1073
Sentence MEK1 in turn phosphorylates and activates ERK1 and ERK2 mitogen-activated protein kinases.
TextMods 56: 'MAPKs' -> 'mitogen-activated protein kinases'
CellType Chondrocytes
TextRef info:pmid/16199873#body:54
PubYear 2005
MedlineTA Mol Cell Biol
MedLine Reference 16199873:1053
Sentence ERK1 and ERK2 are phosphorylated by MEK1 and MEK2 and are primarily activated by growth-promoting stimuli.
CellType Fibroblasts
TextRef info:pmid/15930121#body:158
PubYear 2005
MedlineTA Mol Biol Cell
MedLine Reference 15930121:1157
Sentence We used a widely used inhibitor U0126 to inhibit MEK1, a kinase that directly phosphorylates and activates ERK1/2.
Tissue Serum
TextRef info:pmid/10614633#body:204
PubYear 2000
MedlineTA Endocrinology
MedLine Reference 10614633:1203
Sentence It is well established that MEK1 phosphorylates p42/p44 MAPK, leading to increased Elk-1 transcriptional activity.
Organ Thyroid Gland
Organism Rattus norvegicus
TextRef info:pmid/10553083#body:116
PubYear 1999
MedlineTA J Immunol
MedLine Reference 10553083:1115
Sentence PD98059 blocks ERK1/2 activation by specifically inhibiting MEK1, the kinase that catalyzes ERK1/2 phosphorylation (38).
TextRef info:pmid/15572664#body:46
PubYear 2004
MedlineTA Mol Cell Biol
MedLine Reference 15572664:1045
Sentence Activated B-Raf activates MEK1, which in turn phosphorylates and activates ERK1 and ERK2 for a sustained period.
CellLineName PC 12
TextMods 75: 'ERK1/2 ' -> 'ERK1 and ERK2 '
TextRef info:pmid/11304490#body:199
PubYear 2001
MedlineTA Circ Res
MedLine Reference 11304490:1198
Sentence ERK1 and ERK2 are phosphorylated by MEK1, dimerized, and translocated into the nucleus, where they are visualized in red.
TextRef info:pmid/17913910#body:368
PubYear 2007
MedlineTA J Neurosci
MedLine Reference 17913910:1367
Sentence However, this is unlikely because purified MEK1 phosphorylates and activates ERK1 and ERK2 with similar kinetics (Zheng and Guan, 1993[Go]).
Organ Corpus striatum
TextRef info:pmid/10567369#body:32
PubYear 1999
MedlineTA J Biol Chem
MedLine Reference 10567369:1031
Sentence Raf activates MEK1 and MEK2, the dual-specificity protein kinases that directly phosphorylate and activate ERK1 and ERK2 (2, 3).
TextRef info:pmid/15373836#body:66
PubYear 2004
MedlineTA Eur J Biochem
MedLine Reference 15373836:1065
Sentence Subsequently, Raf1 phosphorylates mitogen-activated protein kinase/ERK kinase (MEK) 1 and 2, which in turn phosphorylate ERK1 and ERK2.
TextMods 34: 'MAPK' -> 'mitogen-activated protein kinase'
TextRef info:pmid/16533948#body:156
PubYear 2006
MedlineTA J Cell Biol
MedLine Reference 16533948:1155
Sentence MEK1-GFP was immunoprecipitated and used to phosphorylate purified GST-Extracellular signal-regulated kinase 1c or GST-ERK1 for the indicated times.
TextMods 71: 'ERK1c ' -> 'Extracellular signal-regulated kinase 1c '
Tissue Serum
TextRef info:pmid/15021912#body:60
PubYear 2004
MedlineTA Oncogene
MedLine Reference 15021912:1059
Sentence MEK1 (Acharya et al., 1998) and tyrosine-phosphorylated ERK1 (Cha and Shapiro, 2001) are involved in regulating Golgi dynamics.
CellLineName HeLa
TextRef info:pmid/10445849#body:67
PubYear 1999
MedlineTA Oncogene
MedLine Reference 10445849:1066
Sentence Activated Raf-1 phosphorylates and activates MEK1 and MEK2 which in turn phosphorylate and activate ERK1 and ERK2 (Marais and Marshall, 1996; Pritchard and McMahon, 1997).
TextRef info:pmid/9724043#body:146
PubYear 1998
MedlineTA Endocrinology
MedLine Reference 9724043:1145
Sentence In turn, activated MEK1 phosphorylates p42mapk and p44mapk at threonine and tyrosine residues within a conserved regulatory region between the TEY motif (14).
CellType Luteal Cells
Organism Bos taurus
TextRef info:pmid/11782450#body:190
PubYear 2002
MedlineTA Genes Dev
MedLine Reference 11782450:1189
Sentence MEK1 specifically phosphorylates and activates ERK1 and ERK2, which are endogenous in NIH3T3 cells, but not other subfamilies of mitogen-activated protein kinases (Chang and Karin 2001).
TextMods 129: 'MAPKs ' -> 'mitogen-activated protein kinases '
TextRef info:pmid/15340077#body:478
PubYear 2004
MedlineTA Mol Cell Biol
MedLine Reference 15340077:1477
Sentence However, this interaction results in extracellular signal-regulated kinase 1/2 inhibition, possibly by blocking MEK1-dependent extracellular signal-regulated kinase 1/2 phosphorylation.
TextMods 37: 'ERK1/2 ' -> 'extracellular signal-regulated kinase 1/2 ' 127: 'ERK1/2 ' -> 'extracellular signal-regulated kinase 1/2 '
TextRef info:pmid/10415066#body:291
PubYear 1999
MedlineTA J Immunol
MedLine Reference 10415066:1290
Sentence This raises the possibility that MEK1 activity is critical for the functional changes observed, and furthermore, that MEK1 or MEK2 may preferentially phosphorylate either ERK1 or ERK2.
CellType Eosinophils
TextRef info:pmid/12730329#body:71
PubYear 2003
MedlineTA Mol Endocrinol
MedLine Reference 12730329:1070
Sentence Two upstream dual specificity enzyme kinases MEK1/MEK2 (MAPKKs) phosphorylate threonine and tyrosine residues of ERK1/2 and initiate an ultrasensitive downstream phosphorylation cascade (25).
TextRef info:pmid/17881458#body:303
PubYear 2007
MedlineTA Am J Physiol Renal Physiol
MedLine Reference 17881458:1302
Sentence MEK1 and MEK2 are known to phosphorylate and activate both ERK1 and ERK2, while ERK5 is activated by another dual-specificity kinase, namely, MEK5 (21, 47, 48).
Tissue Epithelium
Organ Mesenchyme
TextRef info:pmid/10775036#body:48
PubYear 2000
MedlineTA Cell Growth Differ
MedLine Reference 10775036:1047
Sentence The 44 kDa mitogen-activated protein kinase (ERK1) and 42 kDa mitogen-activated protein kinase (ERK2) are phosphorylated and activated by highly specific MEK1 and MEK2 (8, 9, 10, 11, 12) .
TextMods 11: 'MAPK ' -> 'mitogen-activated protein kinase ' 62: 'MAPK ' -> 'mitogen-activated protein kinase '
CellType Fibroblasts
TextRef info:pmid/15509801#body:439
PubYear 2004
MedlineTA Mol Cell Biol
MedLine Reference 15509801:1438
Sentence While the kinetics of phosphorylation of Extracellular signal-regulated kinase1b by MEK1 is similar to that of ERK1 and ERK2, the phosphorylation of Extracellular signal-regulated kinase1c by MEK1 is much slower (Fig. 6).
TextMods 41: 'ERK' -> 'Extracellular signal-regulated kinase' 149: 'ERK' -> 'Extracellular signal-regulated kinase'
TextRef info:pmid/9837893#body:55
PubYear 1998
MedlineTA J Biol Chem
MedLine Reference 9837893:1054
Sentence The major downstream effectors of raf are MAP kinase kinase 1 (MEK/MKK1) and MAP kinase kinase 2 (MEK/MKK2), which in turn phosphorylate and activate ERK1/2 and ultimately activate specific transcription factors (for reviews, see Refs. 19 and 23).
CellType Endothelial Cells
TextRef info:pmid/10231383#body:105
PubYear 1999
MedlineTA Eur J Biochem
MedLine Reference 10231383:1104
Sentence Only lysates of cells cotransfected with the CA-MEK1 expressed the phospho-Erk2 (Fig. 1A, lane 2), demonstrating that the CA-MEK1 mutant was stably expressed, and was able to activate and phosphorylate downstream signaling targets (Erk1 and Erk2) in transfected cells.
TextRef info:pmid/10452980#body:72
PubYear 1999
MedlineTA J Immunol
MedLine Reference 10452980:1071
Sentence Raf-1, a serine/threonine protein kinase, phosphorylates and activates the threonine/tyrosine protein kinase MEK-1 (23), which, in turn, phosphorylates and activates extracellular signal-regulated protein kinase-1 (ERK-1) and ERK-2 (24).
CellType Macrophages
TextRef info:pmid/9077533#body:179
PubYear 1997
MedlineTA J Clin Invest
MedLine Reference 9077533:1178
Sentence MEK 1 activity was assayed in the five subjects who participated in protocol 2 by measuring the ability of MEK1 immune complexes to phosphorylate the recombinant kinase-inactive mitogen-activated protein kinase (p44mitogen-activated protein kinase) (Fig. 4 A).
TextMods 178: 'MAPK ' -> 'mitogen-activated protein kinase ' 215: 'MAPK' -> 'mitogen-activated protein kinase'
Tissue Skeletal muscle
TextRef info:pmid/11734574#body:66
PubYear 2001
MedlineTA J Lipid Res
MedLine Reference 11734574:1065
Sentence Active Raf-1, by phosphorylating at two serine residues, activates the dual-specificity protein kinase MEK1/2 [mitogen-activated protein kinase (mitogen-activated protein kinase)/ERK kinase 1/2], which, in turn, phosphorylates and activates ERK1/ERK2 (18).
TextMods 111: 'MAP ' -> 'mitogen-activated protein ' 145: 'MAPK' -> 'mitogen-activated protein kinase'
TextRef info:pmid/11875099#body:163
PubYear 2002
MedlineTA Mol Endocrinol
MedLine Reference 11875099:1162
Sentence Most growth factors and mitogens activate the ERKs by the sequential activation of the small GTP-binding protein ras, the serine/threonine kinase Raf1, and the dual-specificity kinase MEK1 that directly phosphorylates ERK1 and 2.
Tissue Serum
TextRef info:pmid/12832462#body:57
PubYear 2003
MedlineTA Mol Cell Biol
MedLine Reference 12832462:1056
Sentence Thus, lipopolysaccharide activation of the mitogen-activated protein 2-kinases MEK-1 and -2, which phosphorylate and activate ERK-1 and -2 mitogen-activated protein kinases, is blocked in bone marrow-derived macrophages from TPL-2-deficient mice (10).
TextMods 49: 'MAP ' -> 'mitogen-activated protein ' 145: 'MAP ' -> 'mitogen-activated protein ' 25: '(LPS) ' -> ''
CellType Macrophages
TextRef info:pmid/17921189#body:67
PubYear 2008
MedlineTA J Pharmacol Exp Ther
MedLine Reference 17921189:1066
Sentence The mitogen-activated protein kinase kinases (MKK1/MEK1) phosphorylate and activate the extracellular signal-regulated kinase (ERK)1 and ERK2, and this pathway is important in IL-8 release from Haemophilus influenzae-stimulated human epithelial cells (Wang et al., 2003[Go]).
TextMods 4: 'MAPK ' -> 'mitogen-activated protein kinase '
CellType Epithelial Cells
Organism Homo sapiens
TextRef info:pmid/10358197#body:60
PubYear 1999
MedlineTA J Immunol
MedLine Reference 10358197:1059
Sentence Erk-1 and -2 are phosphorylated and activated by MEK-1 and -2 (mitogen-activated protein/ERK kinase). p38 mitogen-activated protein kinase is activated by mitogen-activated protein kinase kinase -3 (23) and -6 (24), and stress-activated protein kinase is activated by MKK-4 (23) and MKK-7 (25).
TextMods 63: 'MAP' -> 'mitogen-activated protein' 106: 'MAPK ' -> 'mitogen-activated protein kinase ' 155: 'MAP ' -> 'mitogen-activated protein ' 225: 'SAPK ' -> 'stress-activated protein kinase ' 195: '(MKK)' -> ''
TextRef info:pmid/14670833#body:88
PubYear 2003
MedlineTA Circ Res
MedLine Reference 14670833:1087
Sentence Finally, MKK1 or MKK2 phosphorylate a Thr and a Tyr residue within a Thr-Glu-Tyr sequence in ERK1 and ERK2 [also known as p44-mitogen-activated protein kinase (or MAPK1) and p42-mitogen-activated protein kinase (or MAPK2), respectively],21 and thereby activate these species in both the cytoplasmic and nuclear compartments (Figure 3).
TextMods 126: 'MAPK ' -> 'mitogen-activated protein kinase ' 178: 'MAPK ' -> 'mitogen-activated protein kinase '
TextRef info:pmid/18708635#body:311
PubYear 2008
MedlineTA Mol Pharmacol
MedLine Reference 18708635:1310
Sentence Whereas sphingosine-1 phosphate stimulated MEK1-dependent p42/p44 MAPK phosphorylation in Wild-type cells in a concentration-dependent manner, and with a potency consistent with literature values (Mandala et al., 2002[Go]; Sanna et al., 2004[Go]), neither of the mutant receptors was able to elicit significant signal when treated with sphingosine-1 phosphate.
TextMods 8: 'S1P ' -> 'sphingosine-1 phosphate ' 90: 'WT ' -> 'Wild-type ' 336: 'S1P' -> 'sphingosine-1 phosphate'
TextRef info:pmid/18676837#body:73
PubYear 2008
MedlineTA Cancer Res
MedLine Reference 18676837:1072
Sentence Activated Raf phosphorylates and activates the dual specificity kinases MEK1 and MEK2, which successively phosphorylate and activate the proline-directed serine/threonine kinases ERK1 and ERK2, which have multiple downstream targets, including Elk-1, c-Ets1, c-Ets2, p90RSK1, MNK1, MNK2, and TOB (1-3).
TextRef info:pmid/15231670#body:57
PubYear 2004
MedlineTA Cancer Res
MedLine Reference 15231670:1056
Sentence Ras binds to and promotes Raf activation, and activated Raf, in turn, phosphorylates and activates the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)1 and MEK2 dual specificity kinases, which then phosphorylate and activate the ERK1 and ERK2 mitogen-activated protein kinases.
TextRef info:pmid/17709378#body:64
PubYear 2007
MedlineTA Mol Cell Biol
MedLine Reference 17709378:1063
Sentence Only activation of the MAP 2-kinases MEK-1 and -2, which phosphorylate and activate ERK-1 and -2 MAP kinases, is blocked in TPL-2-deficient macrophages following stimulation with lipopolysaccharide (lipopolysaccharide), lipopeptide, or tumor necrosis factor (TNF) (13, 15, 35), while activation of the p38 and JNK MAP kinase pathways is normal.
TextMods 199: 'LPS' -> 'lipopolysaccharide'
CellType Macrophages
TextRef info:pmid/11145995#body:37
PubYear 2001
MedlineTA J Neurochem
MedLine Reference 11145995:1036
Sentence A number of growth factor receptor tyrosine kinases are linked to the small GTP-binding protein Ras and stimulate mitogen-activated protein kinase kinase kinases such as Raf, which phosphorylate and activate mitogen-activated protein kinase kinases, MEK1 and MEK2, which in turn phosphorylate and activate ERK1/2 (Seger and Krebs 1995; Sugden and Clerk 1997; Lewis et al. 1998).
TextMods 114: 'MAPK ' -> 'mitogen-activated protein kinase ' 208: 'MAPK ' -> 'mitogen-activated protein kinase '
CellType Astrocytes
TextRef info:pmid/10508167#body:30
PubYear 1999
MedlineTA EMBO J
MedLine Reference 10508167:1029
Sentence It has been reported that upon activation of the mitogen-activated protein kinase cascade, classical mitogen-activated protein kinases, ERK1 and ERK2, are phosphorylated by MEKs (MEK1 or 2) on threonine and tyrosine residues (Thr188 and Tyr190 in Xenopus mitogen-activated protein kinase=MPK1/ERK2; Payne et al., 1991), and translocate from the cytoplasm to the nucleus (Chen et al., 1992; Gonzalez et al., 1993; Lenormand et al., 1993), where mitogen-activated protein kinases phosphorylate several nuclear targets such as transcription factors.
TextMods 49: 'MAPK ' -> 'mitogen-activated protein kinase ' 101: 'MAPKs' -> 'mitogen-activated protein kinases' 255: 'MAPK' -> 'mitogen-activated protein kinase' 444: 'MAPKs ' -> 'mitogen-activated protein kinases '
TextRef info:pmid/9927426#body:15
MedLine Reference 9927426:1014
Sentence Both p42 and p44MAPK are activated by dual phosphorylation on a threonine and a tyrosine residue, achieved by the dual-specificity kinase MKK1/2.
CellLineName PC 12
CellType fibroblast
Journal EMBO
Journal Reference v18 i3 p664 (1999)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/18/3/664
Source Ariadne Signaling Pathways
TextRef info:pmid/12393899#body:258
MedLine Reference 12393899:1257
Sentence Furthermore, expression of a constitutively active MKK1, which directly activated ERK1/2, suppressed cortical neuron apoptosis induced by expression of recombinant wild-type GSK3eta or the GSK3eta(S9A) mutant.
Tissue cortex
Journal J. Biol. Chem
Journal Reference v277 i51 p49577 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/51/49577
Source Ariadne Signaling Pathways
TextRef info:pmid/9235901#body:32
MedLine Reference 9235901:1031
Sentence In the mammalian Erk1/2 pathway, the proximal kinases Raf-1 and B-Raf phosphorylate and activate the dual function threonine/tyrosine kinases MAP/Erk kinases 1 and 2, which in turn phosphorylate Erk1/2.
CellLineName AR
CellType myocyte
Organ Heart
Journal J. Biol. Chem
Journal Reference v272 i31 p19125 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/31/19125
Source Ariadne Signaling Pathways
TextRef info:pmid/8388392#abs:7
MedLine Reference 8388392:6
Source Ariadne Signaling Pathways
MedLine Reference 0:89855903
Source Ariadne Signaling Pathways
MedLine Reference 3602363184
Source Ariadne Signaling Pathways
MedLine Reference 3395150027
Source Ariadne Signaling Pathways
TextRef info:pmid/12270924#body:207
MedLine Reference 12270924:1206
Tissue gingiva
CellType fibroblast
Journal J. Biol. Chem
Journal Reference v277 i48 p46338 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/48/46338
Source Ariadne Signaling Pathways
TextRef info:pmid/11571275#body:245
MedLine Reference 11571275:1244
CellType cardiomyocyte
Journal J. Biol. Chem
Journal Reference v276 i47 p43842 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/47/43842
Source Ariadne Signaling Pathways
TextRef info:pmid/11585837#body:210
MedLine Reference 11585837:1209
Journal J. Biol. Chem
Journal Reference v276 i49 p46460 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/49/46460
Source Ariadne Signaling Pathways
TextRef info:pmid/12221078#body:306
MedLine Reference 12221078:1305
Journal J. Biol. Chem
Journal Reference v277 i48 p46493 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/48/46493
Source Ariadne Signaling Pathways
TextRef info:pmid/12584202#body:153
MedLine Reference 12584202:1152
Journal J. Biol. Chem
Journal Reference v278 i17 p14753 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/17/14753
Source Ariadne Signaling Pathways
TextRef info:pmid/10415066#body:235
MedLine Reference 10415066:1234
CellType eosinophil
Journal J. Immunol
Journal Reference v163 i3 p1611 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/3/1611
Source Ariadne Signaling Pathways
TextRef info:pmid/11784328#body:85
MedLine Reference 11784328:1084
Journal Eur. J. Biochem
Journal Reference v269 i1 p337 (2002)
Journal Link http://www.ejbiochem.org/cgi/content/full/269/1/337
Source Ariadne Signaling Pathways
TextRef info:pmid/12226077#body:214
MedLine Reference 12226077:1213
Journal J. Biol. Chem
Journal Reference v277 i46 p44417 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/46/44417
Source Ariadne Signaling Pathways
TextRef info:pmid/14638694#body:191
MedLine Reference 14638694:1190
Journal J. Biol. Chem
Journal Reference v279 i7 p5837 (2004)
Journal Link http://www.jbc.org/cgi/content/full/279/7/5837
Source Ariadne Signaling Pathways
TextRef info:pmid/12506122#body:23
MedLine Reference 12506122:1022
Journal J. Biol. Chem
Journal Reference v278 i10 p8118 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/10/8118
Source Ariadne Signaling Pathways
TextRef info:pmid/14704150#body:50
MedLine Reference 14704150:1049
CellType basal cell
Journal J. Biol. Chem
Journal Reference v279 i12 p11051 (2004)
Journal Link http://www.jbc.org/cgi/content/full/279/12/11051
Source Ariadne Signaling Pathways
MedLine Reference 3176599162
CellType T-cell
Journal Cell
Journal Reference v86 i2 p243 (1996)
Journal Link http://www.cell.com/cgi/content/full/86/2/243
Source Ariadne Signaling Pathways
MedLine Reference 4243756627
Journal J. Neurochem
Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2001.00699.x/full/
Source Ariadne Signaling Pathways
TextRef info:pmid/10625698#body:210
MedLine Reference 10625698:1209
Tissue muscle
Journal J. Biol. Chem
Journal Reference v275 i2 p1457 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/2/1457
Source Ariadne Signaling Pathways
TextRef info:pmid/12186872#body:129
MedLine Reference 12186872:1128
Tissue adrenal
Journal J. Biol. Chem
Journal Reference v277 i43 p41259 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/43/41259
Source Ariadne Signaling Pathways
TextRef info:pmid/12270934#body:79
MedLine Reference 12270934:1078
Journal J. Biol. Chem
Journal Reference v277 i48 p46226 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/48/46226
Source Ariadne Signaling Pathways
TextRef info:pmid/10614633#body:167
MedLine Reference 10614633:1166
CellLineName WRT
Journal Endocrinology
Journal Reference v141 i1 p146 (2000)
Journal Link http://endo.endojournals.org/cgi/content/full/141/1/146
Source Ariadne Signaling Pathways
TextRef info:pmid/12837293#abs:6
MedLine Reference 12837293:5
CellLineName HEK 293
Source Ariadne Signaling Pathways
TextRef info:pmid/12700139#body:241
MedLine Reference 12700139:1240
CellLineName ELT3
Tissue smooth muscle
Journal Cell Phys
Journal Reference v285 i2 pC409 (2003)
Journal Link http://ajpcell.physiology.org/cgi/content/full/285/2/C409
Source Ariadne Signaling Pathways
TextRef info:pmid/8631874#body:164
MedLine Reference 8631874:1163
CellLineName OVCAR-3
Journal J. Biol. Chem
Journal Reference v271 i18 p10672 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/18/10672
Source Ariadne Signaling Pathways
TextRef info:pmid/11278974#body:216
MedLine Reference 11278974:1215
CellLineName 3T3 L1
Journal J. Biol. Chem
Journal Reference v276 i15 p11988 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/15/11988
Source Ariadne Signaling Pathways
TextRef info:pmid/15132853#abs:6
MedLine Reference 15132853:5
Organ Prostate
Source Ariadne Signaling Pathways
TextRef info:pmid/9124407#abs:5
MedLine Reference 9124407:4
Organ renal
Source Ariadne Signaling Pathways
TextRef info:pmid/11875099#body:123
MedLine Reference 11875099:1122
Journal Mol. Endocrin
Journal Reference v16 i3 p419 (2002)
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TextRef info:pmid/8939914#body:262
MedLine Reference 8939914:1261
Journal J. Biol. Chem
Journal Reference v271 i47 p29773 (1996)
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TextRef info:pmid/9407138#body:29
MedLine Reference 9407138:1028
Journal J. Biol. Chem
Journal Reference v272 i52 p33422 (1997)
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MedLine Reference 9624172:1105
CellType B-cell
Journal J. Biol. Chem
Journal Reference v273 i25 p15742 (1998)
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TextRef info:pmid/9705360#body:30
MedLine Reference 9705360:1029
Journal J. Biol. Chem
Journal Reference v273 i34 p22145 (1998)
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MedLine Reference 9933637:1089
CellType keratinocyte
Journal J. Biol. Chem
Journal Reference v274 i7 p4347 (1999)
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Tissue mesangia
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TextRef info:pmid/12354752#body:57
MedLine Reference 12354752:1056
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Journal Cell Growth and Diff
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MedLine Reference 3037352022
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Tissue cortex
Organ Brain
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TextRef info:pmid/14871928#body:51
MedLine Reference 14871928:1050
CellType chondrocyte
Journal Genes & Dev
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TextRef info:pmid/10066767#body:25
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TextRef info:pmid/11884280#body:140
MedLine Reference 11884280:1139
Tissue smooth muscle
Journal ATVB
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TextRef info:pmid/14592811#body:145
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Tissue muscle
Journal Cell Phys
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TextRef info:pmid/10545407#body:270
MedLine Reference 10545407:1269
Journal Carcinogenesis
Journal Reference v20 i11 p2063 (1999)
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TextRef info:pmid/10679063#body:140
MedLine Reference 10679063:1139
CellType T-cell
Journal J. Immunol
Journal Reference v164 i5 p2296 (2000)
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TextRef info:pmid/9469449#body:22
MedLine Reference 9469449:1021
Journal J. Immunol
Journal Reference v160 i4 p1875 (1998)
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TextRef info:pmid/11266467#body:268
MedLine Reference 11266467:1267
Journal J. Cell Biol
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TextRef info:pmid/11571286#body:179
MedLine Reference 11571286:1178
CellLineName PR-IR
Journal J. Biol. Chem
Journal Reference v276 i47 p43871 (2001)
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TextRef info:pmid/11726647#body:155
MedLine Reference 11726647:1154
CellLineName HT22
Journal J. Biol. Chem
Journal Reference v277 i6 p4010 (2002)
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TextRef info:pmid/12134066#body:158
MedLine Reference 12134066:1157
CellLineName PY
Journal Mol. Biol. Cell
Journal Reference v13 i7 p2256 (2002)
Journal Link http://www.molbiolcell.org/cgi/content/full/13/7/2256
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TextRef info:pmid/11782450#body:168
MedLine Reference 11782450:1167
CellLineName NIH 3T3
Journal Genes & Dev
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Journal J. Cell Biol
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CellLineName FG
Journal J. Cell Biol
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TextRef info:pmid/10501181#body:132
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CellLineName SH-SY5Y
Journal J. Neurochem
Journal Reference v73 i4 p1384 (1999)
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TextRef info:pmid/10330229#abs:5
MedLine Reference 10330229:4
CellLineName PC6
Source Ariadne Signaling Pathways
TextRef info:pmid/9111071#body:178
MedLine Reference 9111071:1177
CellLineName NIH 3T3
Journal J. Biol. Chem
Journal Reference v272 i17 p11557 (1997)
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TextRef info:pmid/10764798#body:130
MedLine Reference 10764798:1129
CellLineName HepG 2
Journal J. Biol. Chem
Journal Reference v275 i25 p18810 (2000)
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TextRef info:pmid/14699120#body:22
MedLine Reference 14699120:1021
CellLineName MCF7
Journal J. Biol. Chem
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TextRef info:pmid/12969136#abs:12
MedLine Reference 12969136:11
Organ Kidney
Source Ariadne Signaling Pathways
MedLine Reference 3700848305
Source Ariadne Signaling Pathways
MedLine Reference 2775376596
Source Ariadne Signaling Pathways
TextRef info:pmid/15773907#abs:7
MedLine Reference 15773907:6
Organ Brain
Source Ariadne Signaling Pathways
TextRef info:pmid/15653554#abs:10
MedLine Reference 15653554:9
CellType fibroblast
Source Ariadne Signaling Pathways
TextRef info:pmid/12882762#abs:7
MedLine Reference 12882762:6
CellType fibroblast
Source Ariadne Signaling Pathways
TextRef info:pmid/8663194#body:31
MedLine Reference 8663194:1030
CellType myocyte
Organ ventricle
Journal J. Biol. Chem
Journal Reference v271 i28 p16586 (1996)
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TextRef info:pmid/12244120#body:162
MedLine Reference 12244120:1161
Journal J. Biol. Chem
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TextRef info:pmid/11134045#body:200
MedLine Reference 11134045:1199
Journal J. Biol. Chem
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TextRef info:pmid/10722688#body:37
MedLine Reference 10722688:1036
Organ Heart
Journal J. Biol. Chem
Journal Reference v275 i12 p8508 (2000)
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TextRef info:pmid/10024343#body:132
MedLine Reference 10024343:1131
Journal J. Neurosci
Journal Reference v19 i5 p1557 (1999)
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TextRef info:pmid/10409742#body:301
MedLine Reference 10409742:1300
Journal Mol. Cell. Biol
Journal Reference v19 i8 p5523 (1999)
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TextRef info:pmid/11259591#body:19
MedLine Reference 11259591:1018
Journal Mol. Cell. Biol
Journal Reference v21 i7 p2423 (2001)
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TextRef info:pmid/11287604#body:24
MedLine Reference 11287604:1023
Journal Mol. Cell. Biol
Journal Reference v21 i9 p2981 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/9/2981
Source Ariadne Signaling Pathways
TextRef info:pmid/12730329#body:80
MedLine Reference 12730329:1079
Journal Mol. Endocrin
Journal Reference v17 i8 p1593 (2003)
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Source Ariadne Signaling Pathways
TextRef info:pmid/10997909#body:52
MedLine Reference 10997909:1051
Journal Renal Phys
Journal Reference v279 i4 pF593 (2000)
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Source Ariadne Signaling Pathways
TextRef info:pmid/11504919#body:31
MedLine Reference 11504919:1030
Tissue Blood
Journal PNAS
Journal Reference v98 i20 p11569 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/20/11569
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TextRef info:pmid/12808055#body:313
MedLine Reference 12808055:1312
Journal Mol. Biol. Cell
Journal Reference v14 i6 p2603 (2003)
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TextRef info:pmid/11113199#body:292
MedLine Reference 11113199:1291
Journal Mol. Cell. Biol
Journal Reference v21 i1 p249 (2001)
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TextRef info:pmid/11821396#body:153
MedLine Reference 11821396:1152
CellLineName RAW264.7
Journal J. Biol. Chem
Journal Reference v277 i21 p18753 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/21/18753
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TextRef info:pmid/10414983#body:132
MedLine Reference 10414983:1131
CellLineName SH-SY5Y
Journal J. Neurosci
Journal Reference v19 i15 p6549 (1999)
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Source Ariadne Signaling Pathways
TextRef info:pmid/9744861#body:238
MedLine Reference 9744861:1237
Tissue germ
Journal Genes & Dev
Journal Reference v12 i18 p2842 (1998)
Journal Link http://www.genesdev.org/cgi/content/full/12/18/2842
Source Ariadne Signaling Pathways
TextRef info:pmid/11448861#body:282
MedLine Reference 11448861:1281
Tissue Skeletal muscle
Journal Reg.Int.Comp.Phys
Journal Reference v281 i2 pR561 (2001)
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Source Ariadne Signaling Pathways
TextRef info:pmid/10749122#body:80
MedLine Reference 10749122:1079
CellType melanocyte
Journal Cancer Res
Journal Reference v60 i6 p1552 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/6/1552
Source Ariadne Signaling Pathways
TextRef info:pmid/11156425#body:148
MedLine Reference 11156425:1147
CellType fibroblast
Journal Cancer Res
Journal Reference v60 i24 p7156 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/24/7156
Source Ariadne Signaling Pathways
TextRef info:pmid/15215244#body:412
MedLine Reference 15215244:1411
CellType macrophage
Journal J. Biol. Chem
Journal Reference v279 i36 p37597 (2004)
Journal Link http://www.jbc.org/cgi/content/full/279/36/37597
Source Ariadne Signaling Pathways
TextRef info:pmid/14701870#body:55
MedLine Reference 14701870:1054
Journal Genes & Dev
Journal Reference v17 i24 p2993 (2003)
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Source Ariadne Signaling Pathways
TextRef info:pmid/9620846#body:69
MedLine Reference 9620846:1068
CellLineName R1B
Journal Genes & Dev
Journal Reference v12 i11 p1587 (1998)
Journal Link http://www.genesdev.org/cgi/content/full/12/11/1587
Source Ariadne Signaling Pathways
TextRef info:pmid/10446156#body:258
MedLine Reference 10446156:1257
CellLineName ng108-15
Journal J. Biol. Chem
Journal Reference v274 i34 p23901 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/34/23901
Source Ariadne Signaling Pathways
MedLine Reference 4007286107
CellLineName R1B
Source Ariadne Signaling Pathways
MedLine Reference 2345921295
CellLineName NIH 3T3
Source Ariadne Signaling Pathways
TextRef info:pmid/12391277#body:233
MedLine Reference 12391277:1232
CellLineName A3
Journal Mol. Pharm
Journal Reference v62 i5 p1137 (2002)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/62/5/1137
Source Ariadne Signaling Pathways
TextRef info:pmid/10516283#body:26
MedLine Reference 10516283:1025
CellLineName ok
Journal Renal Phys
Journal Reference v277 i4 pF580 (1999)
Journal Link http://ajprenal.physiology.org/cgi/content/full/277/4/F580
Source Ariadne Signaling Pathways
TextRef info:pmid/11560921#body:202
MedLine Reference 11560921:1201
CellLineName Neuro 2A
Journal J. Biol. Chem
Journal Reference v276 i48 p45320 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/48/45320
Source Ariadne Signaling Pathways
TextRef info:pmid/11059787#body:140
MedLine Reference 11059787:1139
CellLineName NEO
Journal Cancer Res
Journal Reference v60 i20 p5887 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/20/5887
Source Ariadne Signaling Pathways
TextRef info:pmid/12832399#body:230
MedLine Reference 12832399:1229
CellLineName NIH 3T3
CellType fibroblast
Journal J. Biol. Chem
Journal Reference v278 i37 p35609 (2003)
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TextRef info:pmid/10748187#body:280
MedLine Reference 10748187:1279
CellLineName HA
Journal J. Biol. Chem
Journal Reference v275 i21 p15799 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/21/15799
Source Ariadne Signaling Pathways
TextRef info:pmid/9891015#abs:6
MedLine Reference 9891015:5
CellType fibroblast
Source Ariadne Signaling Pathways
TextRef info:pmid/9020068#abs:8
MedLine Reference 9020068:7
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TextRef info:pmid/10024371#body:108
MedLine Reference 10024371:1107
Journal J. Neurosci
Journal Reference v19 i5 p1876 (1999)
Journal Link http://www.jneurosci.org/cgi/content/full/19/5/1876
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TextRef info:pmid/11739589#body:113
MedLine Reference 11739589:1112
Journal J. Neurosci
Journal Reference v21 i24 p9814 (2001)
Journal Link http://www.jneurosci.org/cgi/content/full/21/24/9814
Source Ariadne Signaling Pathways
TextRef info:pmid/11756521#body:161
MedLine Reference 11756521:1160
CellType neural
Journal J. Neurosci
Journal Reference v22 i1 pRC191 (2002)
Journal Link http://www.jneurosci.org/cgi/content/full/22/1/RC191
Source Ariadne Signaling Pathways
TextRef info:pmid/9353338#body:22
MedLine Reference 9353338:1021
Tissue spore
Journal J. Biol. Chem
Journal Reference v272 i45 p28695 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/45/28695
Source Ariadne Signaling Pathways
TextRef info:pmid/11571230#body:120
MedLine Reference 11571230:1119
Journal Cell Growth and Diff
Journal Reference v12 i9 p471.h (2001)
Journal Link http://cgd.aacrjournals.org/cgi/content/full/12/9/471.h
Source Ariadne Signaling Pathways
TextRef info:pmid/11684694#body:18
MedLine Reference 11684694:1017
CellType neural
Journal J. Biol. Chem
Journal Reference v277 i1 p528 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/1/528
Source Ariadne Signaling Pathways
TextRef info:pmid/11901160#body:197
MedLine Reference 11901160:1196
CellType astrocyte
Journal J. Biol. Chem
Journal Reference v277 i21 p18670 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/21/18670
Source Ariadne Signaling Pathways
TextRef info:pmid/11425867#body:21
MedLine Reference 11425867:1020
Journal J. Cell Biol
Journal Reference v153 i7 p1355 (2001)
Journal Link http://www.jcb.org/cgi/content/full/153/7/1355
Source Ariadne Signaling Pathways
TextRef info:pmid/12060661#body:209
MedLine Reference 12060661:1208
CellType fibroblast
Organ Skin
Journal J. Biol. Chem
Journal Reference v277 i35 p32360 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/35/32360
Source Ariadne Signaling Pathways
TextRef info:pmid/11342545#body:157
MedLine Reference 11342545:1156
Tissue mesangia
Journal J. Biol. Chem
Journal Reference v276 i28 p26640 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/28/26640
Source Ariadne Signaling Pathways
TextRef info:pmid/10381546#abs:2
MedLine Reference 10381546:1
CellLineName NIH 3T3
Source Ariadne Signaling Pathways
TextRef info:pmid/15331404#abs:4
MedLine Reference 15331404:3
CellLineName CG
CellType neural
Organ hippocampal
Source Ariadne Signaling Pathways
TextRef info:pmid/9407076#body:137
MedLine Reference 9407076:1136
CellLineName IIC9
Journal J. Biol. Chem
Journal Reference v272 i52 p32966 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/52/32966
Source Ariadne Signaling Pathways
TextRef info:pmid/10026223#body:141
MedLine Reference 10026223:1140
CellLineName HEK 293
Journal J. Biol. Chem
Journal Reference v274 i9 p5972 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/9/5972
Source Ariadne Signaling Pathways
TextRef info:pmid/14602717#abs:9
MedLine Reference 14602717:8
Tissue epithelia
Organ gastric
Source Ariadne Signaling Pathways
TextRef info:pmid/10851244#body:144
MedLine Reference 10851244:1143
Journal J. Biol. Chem
Journal Reference v275 i35 p27414 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/35/27414
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TextRef info:pmid/11062239#body:274
MedLine Reference 11062239:1273
Journal J. Biol. Chem
Journal Reference v276 i5 p3650 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/5/3650
Source Ariadne Signaling Pathways
TextRef info:pmid/11287603#body:24
MedLine Reference 11287603:1023
Journal Mol. Cell. Biol
Journal Reference v21 i9 p2981 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/9/2981
Source Ariadne Signaling Pathways
TextRef info:pmid/10706854#body:191
MedLine Reference 10706854:1190
CellType eosinophil
Journal Blood
Journal Reference v95 i6 p1911 (2000)
Journal Link http://www.bloodjournal.org/cgi/content/full/95/6/1911
Source Ariadne Signaling Pathways
TextRef info:pmid/9448290#body:68
MedLine Reference 9448290:1067
Journal PNAS
Journal Reference v95 i3 p1091 (1998)
Journal Link http://www.pnas.org/cgi/content/full/95/3/1091
Source Ariadne Signaling Pathways
TextRef info:pmid/11522656#body:136
MedLine Reference 11522656:1135
Journal Cancer Res
Journal Reference v61 i17 p6569 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/17/6569
Source Ariadne Signaling Pathways
TextRef info:pmid/11504705#body:50
MedLine Reference 11504705:1049
Journal Cell Growth and Diff
Journal Reference v12 i8 p397 (2001)
Journal Link http://cgd.aacrjournals.org/cgi/content/full/12/8/397
Source Ariadne Signaling Pathways
TextRef info:pmid/12839832#body:144
MedLine Reference 12839832:1143
Journal Cell Phys
Journal Reference v285 i5 pC1122 (2003)
Journal Link http://ajpcell.physiology.org/cgi/content/full/285/5/C1122
Source Ariadne Signaling Pathways
TextRef info:pmid/12364332#body:20
MedLine Reference 12364332:1019
Journal J. Biol. Chem
Journal Reference v277 i50 p48565 (2002)
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TextRef info:pmid/11035048#body:158
MedLine Reference 11035048:1157
Tissue marrow
CellType macrophage
Journal J. Immunol
Journal Reference v165 i8 p4165 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/165/8/4165
Source Ariadne Signaling Pathways
TextRef info:pmid/10945876#body:95
MedLine Reference 10945876:1094
CellLineName J774
CellType macrophage
Journal JPET
Journal Reference v294 i3 p1188 (2000)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/294/3/1188
Source Ariadne Signaling Pathways
TextRef info:pmid/12421819#body:133
MedLine Reference 12421819:1132
CellLineName E/F
Journal J. Biol. Chem
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Source Ariadne Signaling Pathways
TextRef info:pmid/14701758#body:257
MedLine Reference 14701758:1256
CellLineName HA
Tissue germ
CellType astrocyte
Organ renal
Journal Pharm. Rev
Journal Reference v24 i2 p875 (2004)
Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2001.00699.x/full/
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TextRef info:pmid/12488531#body:82
MedLine Reference 12488531:1081
CellLineName Sf9
Journal Mol. Pharm
Journal Reference v63 i1 p9 (2003)
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TextRef info:pmid/12359764#body:60
MedLine Reference 12359764:1059
CellLineName LFS
Journal Cancer Res
Journal Reference v62 i19 p5528 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/19/5528
Source Ariadne Signaling Pathways
TextRef info:pmid/15059899#body:14
MedLine Reference 15059899:1013
Organ breast
Journal Cancer Res
Journal Reference v64 i7 p2461 (2004)
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Source Ariadne Signaling Pathways
TextRef info:pmid/11983682#body:211
MedLine Reference 11983682:1210
CellType neural
Organ hippocampal
Journal J. Biol. Chem
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MedLine Reference 11337508:1309
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MedLine Reference 11823456:1018
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MedLine Reference 14617631:1049
CellType chondrocyte
Journal J. Biol. Chem
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TextRef info:pmid/9618377#body:41
MedLine Reference 9618377:1040
CellType myocyte
Organ Trachea
Journal AJRCMB
Journal Reference v18 i6 p736 (1998)
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Source Ariadne Signaling Pathways
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Tissue myometrial
Journal Cell Phys
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Journal Cancer Res
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Tissue smooth muscle
Journal Lipid Res
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Journal JPET
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TextRef info:pmid/10791986#body:217
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Tissue fat
Journal J. Cell Biol
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MedLine Reference 11551901:1125
CellLineName HC11
Journal J. Biol. Chem
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MedLine Reference 4230283650
Organ hippocampal
Source Ariadne Signaling Pathways
TextRef info:pmid/9733512#abs:6
MedLine Reference 9733512:5
Source Ariadne Signaling Pathways
TextRef info:pmid/12008923#abs:4
MedLine Reference 12008923:3
Tissue gingiva
CellType fibroblast
Source Ariadne Signaling Pathways
TextRef info:pmid/10428039#abs:6
MedLine Reference 10428039:5
CellType neural
Source Ariadne Signaling Pathways
TextRef info:pmid/11147804#abs:6
MedLine Reference 11147804:5
CellType myoblast
Source Ariadne Signaling Pathways
TextRef info:pmid/12874275#body:13
MedLine Reference 12874275:1012
Tissue epithelia
Organ Liver
Journal J. Biol. Chem
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TextRef info:pmid/11108712#body:40
MedLine Reference 11108712:1039
Tissue bone
Organ Kidney
Journal J. Biol. Chem
Journal Reference v276 i10 p7586 (2001)
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TextRef info:pmid/9593727#body:25
MedLine Reference 9593727:1024
Journal J. Biol. Chem
Journal Reference v273 i22 p13828 (1998)
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TextRef info:pmid/9603971#body:24
MedLine Reference 9603971:1023
Journal J. Biol. Chem
Journal Reference v273 i23 p14560 (1998)
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TextRef info:pmid/15340077#body:424
MedLine Reference 15340077:1423
Journal Mol. Cell. Biol
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Source Ariadne Signaling Pathways
TextRef info:pmid/11517300#body:108
MedLine Reference 11517300:1107
Journal PNAS
Journal Reference v98 i18 p10102 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/18/10102
Source Ariadne Signaling Pathways
TextRef info:pmid/10574913#body:138
MedLine Reference 10574913:1137
CellLineName HEK 293
Journal J. Biol. Chem
Journal Reference v274 i49 p34531 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/49/34531
Source Ariadne Signaling Pathways
TextRef info:pmid/10781613#body:227
MedLine Reference 10781613:1226
CellLineName T-LAK
CellType T-cell
Journal J. Biol. Chem
Journal Reference v275 i28 p21525 (2000)
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TextRef info:pmid/9452460#body:166
MedLine Reference 9452460:1165
CellLineName THP I
Journal J. Biol. Chem
Journal Reference v273 i6 p3394 (1998)
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TextRef info:pmid/11734617#body:357
MedLine Reference 11734617:1356
CellLineName CHO
Journal Pharm. Rev
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TextRef info:pmid/11592976#body:129
MedLine Reference 11592976:1128
CellLineName rasmc
Journal PNAS
Journal Reference v98 i22 p12802 (2001)
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Source Ariadne Signaling Pathways
TextRef info:pmid/10827000#body:180
MedLine Reference 10827000:1179
Tissue Skeletal muscle
Journal Endocrin. Metabol
Journal Reference v278 i6 pE992 (2000)
Journal Link http://ajpendo.physiology.org/cgi/content/full/278/6/E992
Source Ariadne Signaling Pathways
TextRef info:pmid/11238629#body:40
MedLine Reference 11238629:1039
CellType B-cell
Journal J. Immunol
Journal Reference v166 i6 p3855 (2001)
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TextRef info:pmid/12471138#body:241
MedLine Reference 12471138:1240
CellType phagocyte
Journal J. Immunol
Journal Reference v169 i12 p7026 (2002)
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TextRef info:pmid/10646854#body:182
MedLine Reference 10646854:1181
Journal Cancer Res
Journal Reference v60 i1 p64 (2000)
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TextRef info:pmid/11751416#body:171
MedLine Reference 11751416:1170
Journal Cancer Res
Journal Reference v61 i24 p8909 (2001)
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TextRef info:pmid/7759517#body:29
MedLine Reference 7759517:1028
Journal J. Biol. Chem
Journal Reference v270 i21 p12665 (1995)
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TextRef info:pmid/10629060#body:458
MedLine Reference 10629060:1457
Journal Mol. Cell. Biol
Journal Reference v20 i3 p1030 (2000)
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TextRef info:pmid/11266512#body:131
MedLine Reference 11266512:1130
Journal Mol. Endocrin
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Source Ariadne Signaling Pathways
MedLine Reference 4176548081
CellType T-cell
Journal Cell
Journal Reference v86 i2 p243 (1996)
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Source Ariadne Signaling Pathways
TextRef info:pmid/10601295#body:16
MedLine Reference 10601295:1015
Tissue gingiva
CellType fibroblast
Journal J. Biol. Chem
Journal Reference v274 i52 p37292 (1999)
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TextRef info:pmid/12566304#body:114
MedLine Reference 12566304:1113
Journal Cancer Res
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TextRef info:pmid/14676217#body:164
MedLine Reference 14676217:1163
Journal J. Biol. Chem
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TextRef info:pmid/11042169#body:207
MedLine Reference 11042169:1206
Tissue endothelial
Journal J. Biol. Chem
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TextRef info:pmid/15159407#body:43
MedLine Reference 15159407:1042
Tissue skeletal
Journal J. Biol. Chem
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Source Ariadne Signaling Pathways
TextRef info:pmid/9598824#body:113
MedLine Reference 9598824:1112
Journal ATVB
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Source Ariadne Signaling Pathways
TextRef info:pmid/10359013#body:39
MedLine Reference 10359013:1038
Journal Cell Growth and Diff
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TextRef info:pmid/11032840#body:125
MedLine Reference 11032840:1124
CellType osteoclast
Journal J. Biol. Chem
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TextRef info:pmid/15572664#body:25
MedLine Reference 15572664:1024
CellLineName PC 12
Journal Mol. Cell. Biol
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TextRef info:pmid/15500439#abs:6
MedLine Reference 15500439:5
CellLineName PC 12
Source Ariadne Signaling Pathways
TextRef info:pmid/12688676#abs:3
MedLine Reference 12688676:2
CellLineName DUNNING
Source Ariadne Signaling Pathways
TextRef info:pmid/15358516#abs:6
MedLine Reference 15358516:5
CellLineName H4IIE
Source Ariadne Signaling Pathways
TextRef info:pmid/11777960#body:181
MedLine Reference 11777960:1180
CellLineName NK
Journal J. Immunol
Journal Reference v168 i2 p671 (2002)
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TextRef info:pmid/8940180#body:130
MedLine Reference 8940180:1129
CellLineName Swiss 3T3
Journal J. Biol. Chem
Journal Reference v271 i49 p31612 (1996)
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TextRef info:pmid/10888683#body:197
MedLine Reference 10888683:1196
CellLineName B7
Journal Mol. Biol. Cell
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TextRef info:pmid/12709419#body:186
MedLine Reference 12709419:1185
CellLineName MCF7
Journal J. Biol. Chem
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TextRef info:pmid/10346817#body:16
MedLine Reference 10346817:1015
CellLineName PC6
Journal Genes & Dev
Journal Reference v13 i10 p1289 (1999)
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TextRef info:pmid/9645686#body:234
MedLine Reference 9645686:1233
CellLineName Swiss 3T3
CellType fibroblast
Journal Endocrinology
Journal Reference v139 i7 p3133 (1998)
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TextRef info:pmid/12446729#body:27
MedLine Reference 12446729:1026
CellLineName HEK 293
Journal J. Biol. Chem
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MedLine Reference 11457831:1110
CellLineName HEK 293
Journal J. Biol. Chem
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MedLine Reference 10553083:1093
CellLineName ags
Journal J. Immunol
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MedLine Reference 12594256:1247
CellLineName TLR
CellType macrophage
Journal J. Immunol
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MedLine Reference 15067050:1200
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TextRef info:pmid/11857451#abs:6
MedLine Reference 11857451:5
CellType fibroblast
Source Ariadne Signaling Pathways
TextRef info:pmid/12225966#body:161
MedLine Reference 12225966:1160
Tissue muscle
Journal Cell Phys
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Journal Link http://ajpcell.physiology.org/cgi/content/full/283/4/C1025
Source Ariadne Signaling Pathways
TextRef info:pmid/11356676#body:156
MedLine Reference 11356676:1155
Journal Endocrinology
Journal Reference v142 i6 p2303 (2001)
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TextRef info:pmid/10903502#body:351
MedLine Reference 10903502:1350
Journal Eur. J. Biochem
Journal Reference v267 i15 p4693 (2000)
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TextRef info:pmid/12637525#body:168
MedLine Reference 12637525:1167
Journal J. Biol. Chem
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Source Ariadne Signaling Pathways
TextRef info:pmid/12496361#body:26
MedLine Reference 12496361:1025
Tissue nerve
CellType neural
Journal Mol. Cancer Res
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Source Ariadne Signaling Pathways
TextRef info:pmid/14592950#body:151
MedLine Reference 14592950:1150
Tissue myometrial
Journal Endocrinology
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TextRef info:pmid/12746434#body:161
MedLine Reference 12746434:1160
Journal J. Biol. Chem
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TextRef info:pmid/12110546#body:196
MedLine Reference 12110546:1195
Journal Endocrin. Metabol
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TextRef info:pmid/12939263#body:175
MedLine Reference 12939263:1174
CellLineName mr
Journal J. Biol. Chem
Journal Reference v278 i44 p43060 (2003)
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TextRef info:pmid/10207014#body:204
MedLine Reference 10207014:1203
CellLineName RAJI
Tissue Lymph
Journal J. Biol. Chem
Journal Reference v274 i17 p11930 (1999)
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Source Ariadne Signaling Pathways
TextRef info:pmid/11245463#body:105
MedLine Reference 11245463:1104
CellLineName HCT 116
Journal Cancer Res
Journal Reference v61 i4 p1541 (2001)
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Source Ariadne Signaling Pathways
TextRef info:pmid/15044319#body:95
MedLine Reference 15044319:1094
CellLineName HEK 293
Journal Circulation Res
Journal Reference v94 i9 p1242 (2004)
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TextRef info:pmid/12242299#body:279
MedLine Reference 12242299:1278
CellLineName HeLa
Journal Mol. Cell. Biol
Journal Reference v22 i20 p7226 (2002)
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Source Ariadne Signaling Pathways
TextRef info:pmid/9336344#body:24
MedLine Reference 9336344:1023
CellType macrophage
Journal JPET
Journal Reference v283 i1 p358 (1997)
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Source Ariadne Signaling Pathways
TextRef info:pmid/12490588#body:12
MedLine Reference 12490588:1011
Tissue cardiovascular
Journal JPET
Journal Reference v304 i1 p172 (2003)
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TextRef info:pmid/11427728#body:112
MedLine Reference 11427728:1111
Journal PNAS
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TextRef info:pmid/14559821#body:150
MedLine Reference 14559821:1149
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Journal Cancer Res
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TextRef info:pmid/12960148#body:142
MedLine Reference 12960148:1141
Journal J. Biol. Chem
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TextRef info:pmid/10725745#body:203
MedLine Reference 10725745:1202
Journal J. Immunol
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TextRef info:pmid/9110999#body:25
MedLine Reference 9110999:1024
Journal J. Biol. Chem
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TextRef info:pmid/9148940#body:30
MedLine Reference 9148940:1029
Journal J. Biol. Chem
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TextRef info:pmid/9722546#body:238
MedLine Reference 9722546:1237
Journal J. Biol. Chem
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TextRef info:pmid/9873060#body:59
MedLine Reference 9873060:1058
Journal J. Biol. Chem
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Source Ariadne Signaling Pathways
TextRef info:pmid/12676735#body:121
MedLine Reference 12676735:1120
Journal Renal Phys
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TextRef info:pmid/10231383#body:172
MedLine Reference 10231383:1171
Organ Nervous system
Journal Eur. J. Biochem
Journal Reference v262 i1 p211 (1999)
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Source Ariadne Signaling Pathways
TextRef info:pmid/9746468#body:113
MedLine Reference 9746468:1112
Tissue smooth muscle
Organ Heart
Journal Heart Circul
Journal Reference v275 i4 pH1209 (1998)
Journal Link http://ajpheart.physiology.org/cgi/content/full/275/4/H1209
Source Ariadne Signaling Pathways
TextRef info:pmid/10775036#body:24
MedLine Reference 10775036:1023
Tissue hematological
CellType fibroblast
Journal Cell Growth and Diff
Journal Reference v11 i4 p191 (2000)
Journal Link http://cgd.aacrjournals.org/cgi/content/full/11/4/191
Source Ariadne Signaling Pathways
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MedLine Reference 10636870:1152
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Journal J. Biol. Chem
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MedLine Reference 11292824:1135
CellLineName MG 63
CellType osteoblast
Journal J. Biol. Chem
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Source Ariadne Signaling Pathways
MedLine Reference 3194589753
Tissue germ
Source Ariadne Signaling Pathways
TextRef info:pmid/10828601#abs:2
MedLine Reference 10828601:1
Source Ariadne Signaling Pathways
MedLine Reference 3592805993
Source Ariadne Signaling Pathways
TextRef info:pmid/11410589#body:233
MedLine Reference 11410589:1232
Journal J. Biol. Chem
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Source Ariadne Signaling Pathways
TextRef info:pmid/11124968#body:49
MedLine Reference 11124968:1048
CellType promyelocyte
Journal J. Biol. Chem
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Source Ariadne Signaling Pathways
TextRef info:pmid/12529254#body:191
MedLine Reference 12529254:1190
CellType macrophage
Journal Cell Phys
Journal Reference v284 i2 pC571 (2003)
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Source Ariadne Signaling Pathways
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MedLine Reference 11466342:1139
CellType B-cell
Journal J. Immunol
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Source Ariadne Signaling Pathways
TextRef info:pmid/8393135#abs:2
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TextRef info:pmid/10764657#abs:8
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Journal Eur. J. Biochem
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Tissue smooth muscle
Source Ariadne Signaling Pathways
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Journal Circulation Res
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Journal EMBO
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MedLine Reference 11238126:1107
CellLineName AML
Journal Blood
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TextRef info:pmid/15020233#abs:7
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CellType fibroblast
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Journal Mol. Cell. Biol
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Journal Mol. Cell. Biol
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CellType osteoblast
Journal J. Biol. Chem
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Journal EMBO
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Journal PNAS
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MedLine Reference 3803874240
Sentence MEK1/2 then catalyze the phosphorylation of ERK-1 and -2 on tyrosine and threonine residues, and these activated MAPKs can phosphorylate cytoplasmic or nuclear targets.
CellType neural
Organ cerebellar
Journal J. Cell Biol
Journal Reference v165 i3 p357 (2004)
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Source Ariadne Signaling Pathways
MedLine Reference 3727171833
Sentence This interpretation is supported by studies demonstrating that Mek-1/2-mediated phosphorylation of Erk-1/2 significantly depends on the stimulus properties applied to induce long-term potentiation in hippocampal slices of mice (Winder et al., 1999 ; Selcher et al., 2003 ).
Organ hippocampal
Source Ariadne Signaling Pathways
MedLine Reference 3058607942
Sentence MAPKK1 regulates the activity of the MAP kinases, extracellular signal-regulated protein kinase 1 (ERK1) and ERK2, both of which are expressed in T lymphocytes and are stimulated by the p21 ras pathway in response to TCR triggering (reviewed by Pastor et al., 1995 ).
CellType T-cell
Journal Cell
Journal Reference v86 i2 p243 (1996)
Journal Link http://www.cell.com/cgi/content/full/86/2/243
Source Ariadne Signaling Pathways