| URN | urn:agi-llid:5595 |
|---|---|
| Connectivity | 2516 |
| Name | Mapk3 |
| Description | mitogen activated protein kinase 3 |
| Notes | kinase involved in intracellular signalling; component of Mapk signalling pathway [RGD] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| GDNF -> HSF1 signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling | |
| SELE -> ELK-SRF signaling | |
| NCAM1 -> CREB/ELK-SRF/MYC signaling | |
| PECAM -> SP1 signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| ICAM1 -> AP-1/CREB/ELK-SRF signaling | |
| ThrombopoietinR -> SP1 signaling | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| LeptinR -> ELK-SRF signaling | |
| GHR -> ELK-SRF/MYC signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| FGFR -> RUNX2 signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| IL2R -> ELK-SRF/MYC signaling | |
| IL4R -> ELK-SRF/HMGY signaling | |
| IL6R -> CEBP/ELK-SRF signaling | |
| EctodysplasinR -> AP-1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| TNFRSF6 -> HSF1 signaling | |
| B-cell receptor -> AP-1 signaling | |
| CD19 -> AP-1/ELK-SRF signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| ThromboxaneR -> CREB signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| EDG2 -> ELK-SRF signaling | |
| NeuropeptideYR -> ATF/CREB signaling | |
| SerotoninR1 -> FOS signaling | |
| AdenosineR -> AP-1 signaling | |
| AdrenergicRa -> ELK-SRF signaling | |
| CholecystokininR -> ELK-SRF signaling | |
| GNRHR -> ELK-SRF signaling | |
| GRM1/5 -> CREB signaling | |
| NeurotensinR -> ELK-SRF/AP-1/EGR signaling | |
| OpioidR -> CREB/ELK-SRF/STAT3 signaling | |
| OxytocinR -> ELK-SRF/GATA/AP-1 signaling | |
| ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| SerotoninR2 -> ELK-SRF/GATA4 signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| IL8R -> CREB/EGR signaling | |
| AdrenergicRb -> CREB signaling | |
| AdrenergicRb -> STAT3 signaling | |
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling | |
| TachykininR -> ELK-SRF signaling | |
| VIPR -> CREB/CEBP signaling | |
| DopamineR1 -> CREB/ELK-SRF signaling | |
| FSHR -> CREB/ELK-SRF/GATA4 signaling | |
| GlucagonR -> CREB/ELK-SRF/SP1 signaling | |
| SerotoninR4/6/7 -> NR3C signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| IL1R -> NF-kB signaling | |
| FcIgER -> ELK-SRF signaling | |
| T-cell receptor -> AP-1 signaling | |
| PTPRC -> BCL6 signaling | |
| Notch -> TCF3 signaling | |
| AGER -> CREB/SP1 signaling | |
| UrokinaseR -> ELK-SRF signaling | |
| CholinergicRn -> CREB signaling | |
| CD38 -> NF-kB signaling | |
| the extracellular signal-regulated Raf/Mek/Erk signaling pathway | |
| Copy of 'The extracellular signal-regulated RAF-MEK-ERK signaling pathway' | |
| The extracellular signal-regulated RAF-MEK-ERK signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway |
| GO Molecular Function | transcription regulator activity |
|---|---|
| nucleotide binding | |
| transferase activity | |
| phosphotyrosine binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity |
| GO Cellular Component | protein complex |
|---|---|
| soluble fraction | |
| insoluble fraction | |
| cytoplasm | |
| cytosol | |
| nucleoplasm | |
| nucleolus | |
| cytoskeleton | |
| nucleus | |
| microtubule cytoskeleton |
| GO Biological Process | cell cycle |
|---|---|
| interspecies interaction between organisms | |
| organ morphogenesis | |
| cartilage development | |
| sensory perception of pain | |
| signal transduction | |
| small GTPase mediated signal transduction | |
| intracellular protein kinase cascade | |
| MAPKKK cascade | |
| Ras protein signal transduction | |
| positive regulation of translation | |
| positive regulation of transcription | |
| regulation of transcription factor activity | |
| protein amino acid phosphorylation | |
| phosphorylation | |
| response to DNA damage stimulus | |
| lipopolysaccharide-mediated signaling pathway | |
| response to toxin | |
| response to lipopolysaccharide | |
| response to exogenous dsRNA | |
| protein complex assembly | |
| nuclear translocation of MAPK | |
| intracellular signaling pathway |
| Ariadne Ontology | ERK1-3 |
|---|
| Group | ERK1-3 |
|---|---|
| transcription regulator activity | |
| cell cycle | |
| interspecies interaction between organisms | |
| organ morphogenesis | |
| cartilage development | |
| sensory perception of pain | |
| signal transduction | |
| small GTPase mediated signal transduction | |
| intracellular protein kinase cascade | |
| MAPKKK cascade | |
| Ras protein signal transduction | |
| positive regulation of translation | |
| positive regulation of transcription | |
| regulation of transcription factor activity | |
| protein amino acid phosphorylation | |
| phosphorylation | |
| response to DNA damage stimulus | |
| lipopolysaccharide-mediated signaling pathway | |
| response to toxin | |
| response to lipopolysaccharide | |
| response to exogenous dsRNA | |
| protein complex assembly | |
| nuclear translocation of MAPK | |
| intracellular signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| phosphotyrosine binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| protein complex | |
| soluble fraction | |
| insoluble fraction | |
| cytoplasm | |
| cytosol | |
| nucleoplasm | |
| nucleolus | |
| cytoskeleton | |
| nucleus | |
| microtubule cytoskeleton |
| MedScan ID | 5595 |
|---|
| Hugo ID | 6877 |
|---|
| Human chromosome position | 16p11.2 |
|---|
| LocusLink ID | 5595 |
|---|---|
| 26417 | |
| 50689 | |
| 19095 | |
| 326417 | |
| 531391 | |
| 399480 | |
| 327402 | |
| 557882 |
| Alias | ERK1 |
|---|---|
| PRKM3 | |
| P44ERK1 | |
| P44MAPK | |
| HS44KDAP | |
| HUMKER1A | |
| MGC20180 | |
| mitogen-activated protein kinase 3 | |
| ERT2 | |
| ERK-1 | |
| MAPK 1 | |
| MAPK 3 | |
| p44-ERK1 | |
| p44-MAPK | |
| MAP kinase 1 | |
| MAP kinase 3 | |
| OTTHUMP00000174538 | |
| OTTHUMP00000174541 | |
| MAP kinase isoform p44 | |
| insulin-stimulated MAP2 kinase | |
| mitogen-activated protein kinase 1 | |
| extracellular signal-related kinase 1 | |
| extracellular signal-regulated kinase 1 | |
| microtubule-associated protein 2 kinase | |
| p44 | |
| Mnk1 | |
| Esrk1 | |
| Mtap2k | |
| p44 MAP kinase | |
| pp42/MAP kinase | |
| OTTMUSP00000017735 | |
| OTTMUSP00000017736 | |
| OTTMUSP00000017737 | |
| MAPK1 | |
| ERK I | |
| Esrk I | |
| extracellular signal-regulated kinase (ERK) 1 | |
| Extracellular signal-regulated kinase I | |
| extracellular signal-related kinase 1c | |
| MAP kinase III | |
| MAPK p44 | |
| MAPK3 | |
| Microtubule-associated protein-2 kinase | |
| mitogen activated kinase 3 | |
| mitogen activated protein kinase III | |
| mitogen-activated 3 | |
| mitogen-activated 3 (map kinase 3; p44) | |
| mitogen-activated III | |
| OTTHUMP00000174540 | |
| p44 ERK | |
| p44 mitogen activated protein kinase | |
| p44/42 mapk | |
| p44erk I | |
| protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1) | |
| protein kinase, mitogen-activated 3 | |
| protein kinase, mitogen-activated 3 (MAP kinase 3, p44) | |
| protein kinase, mitogen-activated III | |
| rMNK1 | |
| mitogen activated protein kinase 3 | |
| protein kinase, mitogen activated kinase 3 | |
| extracellular-signal-regulated kinase 1 | |
| Protein kinase mitogen activated 3 (extracellular-signal-regulated kinase 1 ERK1) | |
| protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1) | |
| Serum phospholipid level QTL 1 | |
| similar to extracellular signal-regulated kinase I | |
| similar to microtubule-associated protein-2 kinase | |
| similar to extracellular signal-regulated kinase 1 | |
| Lil2 | |
| Serum phospholipid level QTL I | |
| Lipid Level QTL 2 | |
| Lipid Level QTL II | |
| protein kinase | |
| kinase, mitogen-activated 3 (MAP kinase 3; p44) | |
| Scl23 | |
| protein kinase, mitogen-activated 3 (MAP kinase 3; p44) | |
| similar to extracellular signal-related kinase 1c | |
| fi06b09 | |
| wu:fi06b09 | |
| LOC557882 | |
| chromosome | |
| scaffold | |
| similar to glycogen synthase kinase 3 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 601795 |
|---|---|
| 61408 | |
| OMIM:601795 |
| Mouse chromosome position | 7 61.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0004707 | |
| 0016301 | |
| 0000166 | |
| 0001784 | |
| 0004674 | |
| 0030528 | |
| 0016740 | |
| 0007265 | |
| 0051216 | |
| 0007049 | |
| 0044419 | |
| 0031663 | |
| 0009887 | |
| 0006468 | |
| 0051090 | |
| 0006974 | |
| 0043330 | |
| 0032496 | |
| 0019233 | |
| 0007264 | |
| 0005737 | |
| 0005829 | |
| 0015630 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0004672 | |
| 0000165 | |
| 0023034 | |
| 0000189 | |
| 0016310 | |
| 0045727 | |
| 0006461 | |
| 0009636 | |
| 0007165 | |
| 0005626 | |
| 0043234 | |
| 0005625 | |
| 0007243 | |
| 0045941 | |
| 0005856 | |
| 0005515 | |
| 0005575 | |
| 0003700 | |
| 0007242 | |
| 0004682 | |
| 0008372 | |
| 0004713 | |
| 0004691 | |
| 0000074 |
| Rat chromosome position | 1q36 |
|---|
| Swiss-Prot Accession | P27361 |
|---|---|
| Q8NHX1 | |
| A8CZ58 | |
| Q9BWJ1 | |
| Q7Z3H5 | |
| Q8NHX0 | |
| Q63844 | |
| Q3U2H3 | |
| P21708 | |
| Q4PIY8 | |
| Q62686 | |
| Q9JJ13 | |
| B0LPG3 | |
| Q61531 | |
| Q8K0X5 | |
| Q91YW5 |
| PIR ID | JC1451 |
|---|---|
| A48082 | |
| S28184 |
| Unigene ID | Hs.861 |
|---|---|
| Mm.8385 | |
| Rn.2592 | |
| Bt.5687 | |
| Dr.113689 |
| KEGG ID | hsa:5595 |
|---|---|
| mmu:26417 | |
| rno:50689 |
| EC Number | 2.7.11.24 |
|---|---|
| 2.7.11.1 | |
| 2.7.1.37 | |
| 2.7.1.- |
| Swiss-Prot ID | MK03_RAT |
|---|---|
| MK03_HUMAN | |
| MK03_MOUSE | |
| A8CZ58_HUMAN | |
| Q9BWJ1_HUMAN | |
| Q8NHX1_HUMAN | |
| B0LPG3_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Plasma membrane |
| IPI ID | IPI00206172 |
|---|---|
| IPI00231081 | |
| IPI00018195 | |
| IPI00230277 | |
| IPI00304111 | |
| IPI00793141 | |
| IPI00742900 | |
| IPI00654328 | |
| IPI00750828 | |
| IPI00776948 |
| Homologene ID | 55682 |
|---|
| RGD ID | 3046 |
|---|
| MGI ID | 1346859 |
|---|---|
| 105920 |
| Microarray ID | 101834_at |
|---|---|
| 1427060_at |
| FunctionalClass | ATP binding |
|---|---|
| MAP kinase | |
| nucleotide binding | |
| protein binding | |
| protein serine/threonine kinase | |
| transferase | |
| kinase | |
| phosphotyrosine binding | |
| protein kinase | |
| protein-tyrosine kinase | |
| cAMP-dependent protein kinase | |
| protein kinase CK2 |
| Mus musculus Chromosome position | 7 61.0 cM |
|---|
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| KEGG pathway | Adherens junction |
|---|---|
| Axon guidance | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Dorso-ventral axis formation | |
| Endometrial cancer | |
| ErbB signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Focal adhesion | |
| Gap junction | |
| Glioma | |
| GnRH signaling pathway | |
| Insulin signaling pathway | |
| Long-term depression | |
| Long-term potentiation | |
| MAPK signaling pathway | |
| Melanogenesis | |
| Melanoma | |
| Natural killer cell mediated cytotoxicity | |
| Non-small cell lung cancer | |
| Pancreatic cancer | |
| Regulation of actin cytoskeleton | |
| Renal cell carcinoma | |
| TGF-beta signaling pathway | |
| Thyroid cancer | |
| Type II diabetes mellitus | |
| VEGF signaling pathway | |
| mTOR signaling pathway |
| Homo sapiens Chromosome position | 16p12-p11.2 |
|---|---|
| 16p11.2 |
| Hugo Symbol | MAPK3 |
|---|
| Bos taurus Chromosome position | 25 |
|---|
| Danio rerio Chromosome position | LG 3 |
|---|
| LocatorString | pmquery:egfr+transactivation |
|---|
| Rattus norvegicus Chromosome position | 1q36 |
|---|