Ariadne Genomics Inc. Mapk1 Pp2a Dusp6 Map2k2 Map2k1 Erk cytoplasmic/other targets Ksr1 Ksr2 Raf members upstream Ras RTK, others effectors/adapters Erk nuclear targets Erk activated MAPKAPK Pebp1 ---- Raf members Pebp1 ---| Raf members Pebp1 Raf members --+> Map2k2 Raf members --+> Map2k1 Pp2a --+> Raf members Pp2a ---| Map2k2 upstream Ras --+> Raf members effectors/adapters <--> upstream Ras Mapk3 Mapk1 ---> Erk nuclear targets Mapk3 ---> Erk cytoplasmic/other targets Mapk1 ---> Erk cytoplasmic/other targets Mapk3 ---> Erk nuclear targets effectors/adapters ---- RTK, others Ptprr ---| Mapk1 Map2k2 --+> Mapk3 Map2k1 --+> Mapk3 Map2k1 --+> Mapk1 Map2k2 --+> Mapk1 Pp2a ---| Map2k1 Pp2a ---| Mapk1 Pp2a ---| Mapk3 Dusp6 ---| Mapk1 Dusp6 ---| Mapk3 Ptprr ---| Mapk3 Mapk1 --+> Erk activated MAPKAPK Mapk3 --+> Erk activated MAPKAPK Ksr2 ---- Map2k1 Ksr1 ---- Map2k2 Ksr2 ---- Map2k2 Ksr1 ---- Raf members Ptprr