| URN | urn:agi-llid:7458 |
|---|---|
| Total Entities | 0 |
| Connectivity | 34 |
| Name | Eif4h |
| Description | eukaryotic translation initiation factor 4H |
| Notes | This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | translation initiation factor activity |
|---|---|
| translation factor activity, nucleic acid binding | |
| nucleotide binding | |
| nucleic acid binding | |
| RNA binding |
| GO Cellular Component | eukaryotic translation initiation factor 4F complex |
|---|---|
| cytoplasm | |
| cytosol | |
| perinuclear region of cytoplasm |
| GO Biological Process | sexual reproduction |
|---|---|
| developmental growth | |
| regulation of translational initiation | |
| translational initiation | |
| cellular protein metabolic process | |
| translation | |
| gene expression | |
| modulation by virus of host morphology or physiology |
| Pathway | translation pathway |
|---|
| Group | Translation |
|---|---|
| sexual reproduction | |
| developmental growth | |
| regulation of translational initiation | |
| translational initiation | |
| translation initiation factor activity | |
| cellular protein metabolic process | |
| translation | |
| translation factor activity, nucleic acid binding | |
| gene expression | |
| modulation by virus of host morphology or physiology | |
| nucleotide binding | |
| nucleic acid binding | |
| RNA binding | |
| eukaryotic translation initiation factor 4F complex | |
| cytoplasm | |
| cytosol | |
| perinuclear region of cytoplasm |
| LocusLink ID | 7458 |
|---|---|
| 22384 | |
| 288599 |
| Cell Localization | Cytoplasm |
|---|---|
| Perinuclear region |
| GO ID | 0003723 |
|---|---|
| 0000166 | |
| 0008135 | |
| 0003743 | |
| 0044267 | |
| 0048589 | |
| 0010467 | |
| 0019048 | |
| 0006446 | |
| 0019953 | |
| 0006412 | |
| 0006413 | |
| 0005829 | |
| 0016281 | |
| 0048471 | |
| 0003676 | |
| 0005737 |
| Alias | WSCR1 |
|---|---|
| WBSCR1 | |
| eIF-4H | |
| eukaryotic translation initiation factor 4H | |
| Williams-Beuren syndrome chromosome region 1 | |
| Ef4h | |
| AU018978 | |
| mKIAA0038 | |
| D5Ertd355e | |
| E430026L18Rik | |
| Williams-Beuren syndrome chromosome region 1 homolog | |
| williams-Beuren syndrome chromosomal region 1 protein homolog | |
| Wbscr I | |
| LOC367990 | |
| LOC91811 | |
| WSCR I | |
| LOC93527 | |
| LOC221889 | |
| LOC94573 | |
| MGC94887 | |
| OTTHUMP00000024643 | |
| Wbscr1 alternative spliced product | |
| williams-Beuren syndrome chromosomal region 1 protein | |
| Williams-Beuren syndrome chromosome region I | |
| LOC155284 | |
| DNA segment, Chr 5, ERATO Doi 355, expressed | |
| E430026L18 | |
| KIAA0038 | |
| EIF4H | |
| eIF-4Hs | |
| eukaryotic initiation factor 4H | |
| Eukaryotic translation initiating factor 4H | |
| eukaryotic translation initiation factor 4H isoform II | |
| eukaryotic translation initiating factor 4H isoform 2 | |
| eukaryotic translation initiating factor 4H isoform I | |
| eukaryotic translation initiating factor 4H isoform II | |
| eukaryotic translation initiation factor 4H isoform 1 | |
| eukaryotic translation initiation factor 4H isoform 2 | |
| eukaryotic translation initiation factor 4H isoform I | |
| eukaryotic translation initiating factor 4H isoform 1 |
| Mouse chromosome position | 5 74.71 cM |
|---|
| OMIM ID | 603431 |
|---|
| Rat chromosome position | 12q12 |
|---|
| Hugo ID | 12741 |
|---|
| Human chromosome position | 7q11.23 |
|---|
| Swiss-Prot Accession | Q15056 |
|---|---|
| Q564E5 | |
| Q9WUK2 | |
| Q5XI72 | |
| Q9WUK3 | |
| A8K3R1 | |
| D3DXF6 | |
| D3DXF8 |
| Unigene ID | Hs.520943 |
|---|---|
| Mm.27955 | |
| Rn.79423 |
| KEGG ID | hsa:7458 |
|---|---|
| mmu:22384 | |
| rno:288599 |
| Swiss-Prot ID | IF4H_RAT |
|---|---|
| IF4H_MOUSE | |
| IF4H_HUMAN |
| Ensembl ID | ENSG00000106682 |
|---|---|
| ENSP00000265753 | |
| ENST00000265753 | |
| ENSP00000265754 | |
| ENST00000353999 | |
| ENSMUSG00000040731 | |
| ENSMUSP00000048833 | |
| ENSMUST00000036125 | |
| ENSRNOG00000001454 | |
| ENSRNOP00000043254 | |
| ENSRNOT00000050059 |
| Homologene ID | 32536 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1341822 |
|---|
| RGD ID | 1359222 |
|---|
| MedScan ID | 7458 |
|---|