| URN | urn:agi-llid:9669 |
|---|---|
| Total Entities | 0 |
| Connectivity | 50 |
| Name | EIf5b |
| Description | eukaryotic translation initiation factor 5B |
| Notes | Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | GTPase activity |
|---|---|
| translation initiation factor activity | |
| nucleotide binding | |
| GTP binding |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | regulation of translational initiation |
|---|---|
| translational initiation | |
| cellular protein metabolic process | |
| translation | |
| gene expression |
| Pathway | Translation |
|---|---|
| translation pathway |
| Group | Translation |
|---|---|
| GTPase activity | |
| regulation of translational initiation | |
| translational initiation | |
| translation initiation factor activity | |
| cellular protein metabolic process | |
| translation | |
| gene expression | |
| nucleotide binding | |
| GTP binding | |
| cytoplasm | |
| cytosol |
| LocusLink ID | 9669 |
|---|---|
| 226982 | |
| 308306 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0003743 | |
| 0044267 | |
| 0010467 | |
| 0006446 | |
| 0006412 | |
| 0006413 | |
| 0005829 | |
| 0000166 | |
| 0005737 |
| Alias | IF2 |
|---|---|
| eukaryotic translation initiation factor 5B | |
| eIF-5B | |
| translation initiation factor IF2 | |
| translation initiation factor IF-2 | |
| BC018347 | |
| A030003E17Rik | |
| annexin V-binding protein ABP-7 | |
| KIAA0741 | |
| EIF5B | |
| LOC51590 | |
| LOC308306 | |
| LOC226980 | |
| FLJ10524 | |
| MTV-induced circulating interferon | |
| DKFZp434I036 | |
| cDNA sequence BC018347 | |
| A030003E17 | |
| eukaryotic translation initiation factor 5B, pseudogene 1 |
| Mouse chromosome position | 1 |
|---|
| OMIM ID | 606086 |
|---|
| Rat chromosome position | 9q21 |
|---|
| Hugo ID | 30793 |
|---|
| Human chromosome position | 2q11.2 |
|---|
| Swiss-Prot Accession | O60841 |
|---|---|
| Q8N5A0 | |
| Q05D44 | |
| Q6A002 | |
| B2GUV7 | |
| Q3SYI4 | |
| Q3TQJ8 | |
| Q3UL37 | |
| Q3UM39 | |
| Q6PAI0 | |
| Q8CFF4 | |
| Q8CGD6 | |
| O95805 | |
| Q53RV7 | |
| Q53SI8 | |
| Q9UF81 | |
| Q9UMN7 | |
| A0JN31 | |
| P70488 |
| PIR ID | T43483 |
|---|
| Unigene ID | Hs.158688 |
|---|---|
| Mm.260943 | |
| Rn.107482 |
| KEGG ID | hsa:9669 |
|---|---|
| mmu:226982 | |
| rno:308306 |
| Swiss-Prot ID | IF2P_MOUSE |
|---|---|
| IF2P_HUMAN | |
| IF2P_RAT |
| Ensembl ID | ENSG00000158417 |
|---|---|
| ENSP00000289371 | |
| ENST00000289371 | |
| ENSMUSG00000026083 | |
| ENSMUSP00000027252 | |
| ENSMUST00000027252 | |
| ENSRNOG00000023356 | |
| ENSRNOP00000036844 | |
| ENSRNOT00000035785 |
| Homologene ID | 5291 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2441772 |
|---|
| RGD ID | 735017 |
|---|
| MedScan ID | 9669 |
|---|