| URN | urn:agi-llid:2107 |
|---|---|
| Total Entities | 0 |
| Connectivity | 138 |
| Name | Etf1 |
| Description | eukaryotic translation termination factor 1 |
| Notes | This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013] |
| GO Molecular Function | translation termination factor activity |
|---|---|
| translation release factor activity | |
| translation release factor activity, codon specific | |
| RNA binding | |
| ribosome binding |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | translational termination |
|---|---|
| regulation of translational termination | |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
| RNA metabolic process | |
| mRNA metabolic process | |
| cellular protein metabolic process | |
| protein methylation | |
| translation | |
| gene expression | |
| viral process |
| Pathway | Translation |
|---|---|
| translation pathway |
| Group | Translation |
|---|---|
| translational termination | |
| regulation of translational termination | |
| translation termination factor activity | |
| translation release factor activity | |
| translation release factor activity, codon specific | |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
| RNA metabolic process | |
| mRNA metabolic process | |
| cellular protein metabolic process | |
| protein methylation | |
| translation | |
| gene expression | |
| viral process | |
| RNA binding | |
| ribosome binding | |
| cytoplasm | |
| cytosol |
| LocusLink ID | 2107 |
|---|---|
| 225363 | |
| 307503 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0003723 |
|---|---|
| 0043022 | |
| 0003747 | |
| 0016149 | |
| 0008079 | |
| 0016070 | |
| 0044267 | |
| 0010467 | |
| 0016071 | |
| 0000184 | |
| 0006479 | |
| 0006449 | |
| 0006412 | |
| 0006415 | |
| 0005737 | |
| 0005829 | |
| 0016032 |
| Alias | ERF |
|---|---|
| RF1 | |
| ERF1 | |
| TB3-1 | |
| D5S1995 | |
| SUP45L1 | |
| eukaryotic peptide chain release factor subunit 1 | |
| protein Cl1 | |
| polypeptide chain release factor 1 | |
| sup45 (yeast omnipotent suppressor 45) homolog-like 1 | |
| AI463371 | |
| D6Ertd109e | |
| eukaryotic release factor 1 | |
| sup45 (yeast omnipotent suppressor 45) homolog-like I | |
| polypeptide chain release factor I | |
| sup45 ( omnipotent suppressor 45) homolog-like 1 | |
| sup45 ( omnipotent suppressor 45) homolog-like I | |
| sup45 homolog-like 1 | |
| sup45 homolog-like I | |
| SUP45L I | |
| MGC18745 | |
| TB3 I | |
| MGC111066 | |
| RF I | |
| MGC94734 | |
| eRF I | |
| ETF I | |
| ETF1 | |
| eukaryotic translation termination factor I | |
| Eukaryotic release factor I | |
| eukaryotic translation terminating factor 1 | |
| eukaryotic translation terminating factor I | |
| eukaryotic translation termination factor 1 | |
| Eukaryotic peptide chain release factor subunit I | |
| DNA segment, Chr 6, ERATO Doi 109, expressed |
| Mouse chromosome position | 18 |
|---|
| OMIM ID | 600285 |
|---|
| Rat chromosome position | 18p12 |
|---|
| Hugo ID | 3477 |
|---|
| Human chromosome position | 5q31.1 |
|---|
| Swiss-Prot Accession | Q96CG1 |
|---|---|
| B7Z7P8 | |
| P62495 | |
| Q3TF02 | |
| Q8BWY3 | |
| Q5U2Q7 | |
| B2R6B4 | |
| D3DQC1 | |
| P46055 | |
| Q5M7Z7 | |
| Q3TPZ6 | |
| Q91VH9 |
| PIR ID | S50853 |
|---|
| Unigene ID | Hs.483494 |
|---|---|
| Mm.329353 | |
| Rn.228952 |
| KEGG ID | hsa:2107 |
|---|---|
| mmu:225363 | |
| rno:307503 |
| Swiss-Prot ID | ERF1_HUMAN |
|---|---|
| ERF1_MOUSE | |
| ERF1_RAT |
| Ensembl ID | ENSG00000120705 |
|---|---|
| ENSP00000353741 | |
| ENST00000360541 | |
| ENSP00000421288 | |
| ENST00000499810 | |
| ENSMUSG00000024360 | |
| ENSMUSP00000025218 | |
| ENSMUST00000025218 | |
| ENSRNOG00000019450 | |
| ENSRNOP00000026398 | |
| ENSRNOT00000026398 |
| Homologene ID | 3475 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2385071 |
|---|
| RGD ID | 1305712 |
|---|
| MedScan ID | 2107 |
|---|