| URN | urn:agi-llid:6059 |
|---|---|
| Total Entities | 0 |
| Connectivity | 86 |
| Name | Abce1 |
| Description | ATP-binding cassette, sub-family E (OABP), member 1 |
| Notes | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | ATPase activity |
|---|---|
| ribonuclease inhibitor activity | |
| nucleoside-triphosphatase activity | |
| nucleotide binding | |
| ATP binding | |
| iron-sulfur cluster binding |
| GO Cellular Component | cytoplasm |
|---|---|
| mitochondrion |
| GO Biological Process | response to virus |
|---|---|
| RNA catabolic process | |
| modulation by virus of host morphology or physiology |
| Pathway | Translation |
|---|---|
| translation pathway |
| Group | ATPase activity |
|---|---|
| response to virus | |
| ribonuclease inhibitor activity | |
| nucleoside-triphosphatase activity | |
| RNA catabolic process | |
| modulation by virus of host morphology or physiology | |
| nucleotide binding | |
| ATP binding | |
| iron-sulfur cluster binding | |
| cytoplasm | |
| mitochondrion | |
| Secreted proteins |
| LocusLink ID | 6059 |
|---|---|
| 24015 | |
| 361390 |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondrion |
| GO ID | 0005524 |
|---|---|
| 0016887 | |
| 0051536 | |
| 0008428 | |
| 0006401 | |
| 0019048 | |
| 0009615 | |
| 0005737 | |
| 0005739 | |
| 0017111 | |
| 0000166 |
| Alias | RLI |
|---|---|
| OABP | |
| ABC38 | |
| RNS4I | |
| RNASEL1 | |
| RNASELI | |
| OK/SW-cl.40 | |
| ATP-binding cassette sub-family E member 1 | |
| huHP68 | |
| RNase L inhibitor | |
| ribonuclease 4 inhibitor | |
| 2'-5'-oligoadenylate-binding protein | |
| ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor | |
| RNS41 | |
| C79080 | |
| RNS4l (Eye) | |
| ATP-binding cassette, subfamily E, member 1 | |
| ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) inhibitor | |
| ATP-binding cassette, sub-family E (OABP), member 1 | |
| ribonuclease L (2', 5'-oligoisoadenylate synthase-dependent) inhibitor | |
| RNASEL I | |
| RNASELIs | |
| rns4l | |
| OTTHUMP00000220421 | |
| ATP-binding cassette, subfamily E (OABP), member 1 | |
| LOC133164 | |
| ATP-binding cassette transporter E I | |
| LOC152967 | |
| Abce I | |
| Abce1 | |
| ATP-binding cassette transporter E (OABP) 1 | |
| ATP-binding cassette transporter E 1 | |
| ATP-binding cassette transporter E (OABP) I | |
| ATP-binding cassette, sub-family E (OABP), member I | |
| ATP-binding cassette, sub-family E, member I | |
| ATP-binding cassette, subfamily E, member I | |
| ATP-binding cassette, sub-family E, member 1 |
| Mouse chromosome position | 8 |
|---|
| OMIM ID | 601213 |
|---|
| Rat chromosome position | 19q11 |
|---|
| Hugo ID | 69 |
|---|
| Human chromosome position | 4q31 |
|---|
| Swiss-Prot Accession | P61221 |
|---|---|
| P61222 | |
| Q3TJM9 | |
| Q3UHY8 | |
| D3ZD23 | |
| O88793 | |
| Q13181 | |
| Q13864 | |
| Q6NR76 | |
| Q96AL0 | |
| Q96B10 | |
| Q99K66 |
| PIR ID | A57017 |
|---|---|
| S63672 | |
| JC6555 |
| Unigene ID | Hs.12013 |
|---|---|
| Mm.5831 | |
| Rn.2961 |
| KEGG ID | hsa:6059 |
|---|---|
| mmu:24015 | |
| rno:361390 |
| Swiss-Prot ID | ABCE1_HUMAN |
|---|---|
| ABCE1_MOUSE |
| Ensembl ID | ENSG00000164163 |
|---|---|
| ENSP00000296577 | |
| ENST00000296577 | |
| ENSMUSG00000058355 | |
| ENSMUSP00000079379 | |
| ENSMUST00000080536 | |
| ENSRNOG00000018345 | |
| ENSRNOP00000024753 | |
| ENSRNOT00000024753 |
| Homologene ID | 2205 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1195458 |
|---|
| RGD ID | 1305301 |
|---|
| MedScan ID | 6059 |
|---|